Highly efficient and versatile synthesis of libraries of constrained β-strand mimetics

The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels-Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mimic the β-strand seco...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-09, Vol.8 (17), p.2321-2326
Hauptverfasser:	Ogbu, Cyprian O., Qabar, Maher N., Boatman, P.Douglas, Urban, Jan, Meara, Joseph P., Ferguson, Mark D., Tulinsky, John, Lum, Chris, Babu, Suresh, Blaskovich, Mark A., Nakanishi, Hiroshi, Ruan, Fuqiang, Cao, Bolong, Minarik, Ryan, Little, Tom, Nelson, Sherry, Nguyen, Minh, Gall, Anna, Kann, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Chymases Indicators and Reagents Kallikreins - antagonists & inhibitors Kinetics Models, Molecular Peptide Library Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Protein Structure, Secondary Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship Thrombin - antagonists & inhibitors Trypsin Inhibitors - chemical synthesis Trypsin Inhibitors - chemistry Trypsin Inhibitors - pharmacology Tryptases
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