The Effects of Acute Dopamine Reuptake Inhibition on Performance
Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C). The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and ther...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2008-05, Vol.40 (5), p.879-885 |
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| container_title | Medicine and science in sports and exercise |
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| creator | ROELANDS, Bart HASEGAWA, Hiroshi WATSON, Phillip PIACENTINI, Maria Francesca BUYSE, Luk DE SCHUTTER, Guy MEEUSEN, Romain R |
| description | Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C).
The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and thermoregulation during prolonged exercise in temperate and warm conditions.
Eight healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (PLA; 20 mg) or methylphenidate (MPH; Ritalin; 20 mg) 1 h before the start of exercise in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial (TT; PLA18 and MPH18; PLA30 and MPH30) to measure exercise performance.
MPH did not influence TT performance at 18 degrees C (P = 0.397). TT was completed 16% faster in MPH30 (38.1 +/- 6.4 min) than in PLA30 (45.4 +/- 7.3 min; P = 0.049). In the heat Tcore was significantly higher at rest (P = 0.009), and throughout the TT in MPH30 (P < 0.018), reaching values above 40 degrees C. Throughout MPH30, heart rates were significantly higher (P < 0.05).
These results show that MPH has a clear ergogenic effect that was not apparent in 18 degrees C. The combination of a dopamine reuptake inhibitor and exercise in the heat clearly improved performance and caused hyperthermia without any change in the perception of effort or thermal stress compared with the PLA trial. This response may potentially increase the risk of developing heat illness during exercise in individuals taking drugs of this nature. |
| doi_str_mv | 10.1249/mss.0b013e3181659c4d |
| format | Article |
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The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and thermoregulation during prolonged exercise in temperate and warm conditions.
Eight healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (PLA; 20 mg) or methylphenidate (MPH; Ritalin; 20 mg) 1 h before the start of exercise in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial (TT; PLA18 and MPH18; PLA30 and MPH30) to measure exercise performance.
MPH did not influence TT performance at 18 degrees C (P = 0.397). TT was completed 16% faster in MPH30 (38.1 +/- 6.4 min) than in PLA30 (45.4 +/- 7.3 min; P = 0.049). In the heat Tcore was significantly higher at rest (P = 0.009), and throughout the TT in MPH30 (P < 0.018), reaching values above 40 degrees C. Throughout MPH30, heart rates were significantly higher (P < 0.05).
These results show that MPH has a clear ergogenic effect that was not apparent in 18 degrees C. The combination of a dopamine reuptake inhibitor and exercise in the heat clearly improved performance and caused hyperthermia without any change in the perception of effort or thermal stress compared with the PLA trial. This response may potentially increase the risk of developing heat illness during exercise in individuals taking drugs of this nature.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/mss.0b013e3181659c4d</identifier><identifier>PMID: 18408610</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; Body Temperature Regulation - drug effects ; Body Temperature Regulation - physiology ; Cross-Over Studies ; Dopamine - metabolism ; Dopamine Uptake Inhibitors - administration & dosage ; Dopamine Uptake Inhibitors - pharmacology ; Double-Blind Method ; Exercise - physiology ; Fundamental and applied biological sciences. Psychology ; Heart Rate - physiology ; Hot Temperature ; Humans ; Male ; Methylphenidate - administration & dosage ; Methylphenidate - pharmacology ; Space life sciences ; Time Factors ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Medicine and science in sports and exercise, 2008-05, Vol.40 (5), p.879-885</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-9d30a4e95a318adb2b0857bd25702744b3d167042a6746d3930087fad4264c053</citedby><cites>FETCH-LOGICAL-c447t-9d30a4e95a318adb2b0857bd25702744b3d167042a6746d3930087fad4264c053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20289815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18408610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROELANDS, Bart</creatorcontrib><creatorcontrib>HASEGAWA, Hiroshi</creatorcontrib><creatorcontrib>WATSON, Phillip</creatorcontrib><creatorcontrib>PIACENTINI, Maria Francesca</creatorcontrib><creatorcontrib>BUYSE, Luk</creatorcontrib><creatorcontrib>DE SCHUTTER, Guy</creatorcontrib><creatorcontrib>MEEUSEN, Romain R</creatorcontrib><title>The Effects of Acute Dopamine Reuptake Inhibition on Performance</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C).
The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and thermoregulation during prolonged exercise in temperate and warm conditions.
Eight healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (PLA; 20 mg) or methylphenidate (MPH; Ritalin; 20 mg) 1 h before the start of exercise in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial (TT; PLA18 and MPH18; PLA30 and MPH30) to measure exercise performance.
MPH did not influence TT performance at 18 degrees C (P = 0.397). TT was completed 16% faster in MPH30 (38.1 +/- 6.4 min) than in PLA30 (45.4 +/- 7.3 min; P = 0.049). In the heat Tcore was significantly higher at rest (P = 0.009), and throughout the TT in MPH30 (P < 0.018), reaching values above 40 degrees C. Throughout MPH30, heart rates were significantly higher (P < 0.05).
These results show that MPH has a clear ergogenic effect that was not apparent in 18 degrees C. The combination of a dopamine reuptake inhibitor and exercise in the heat clearly improved performance and caused hyperthermia without any change in the perception of effort or thermal stress compared with the PLA trial. This response may potentially increase the risk of developing heat illness during exercise in individuals taking drugs of this nature.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Body Temperature Regulation - physiology</subject><subject>Cross-Over Studies</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Uptake Inhibitors - administration & dosage</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Double-Blind Method</subject><subject>Exercise - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - physiology</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Male</subject><subject>Methylphenidate - administration & dosage</subject><subject>Methylphenidate - pharmacology</subject><subject>Space life sciences</subject><subject>Time Factors</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. 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Psychology</topic><topic>Heart Rate - physiology</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Male</topic><topic>Methylphenidate - administration & dosage</topic><topic>Methylphenidate - pharmacology</topic><topic>Space life sciences</topic><topic>Time Factors</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROELANDS, Bart</creatorcontrib><creatorcontrib>HASEGAWA, Hiroshi</creatorcontrib><creatorcontrib>WATSON, Phillip</creatorcontrib><creatorcontrib>PIACENTINI, Maria Francesca</creatorcontrib><creatorcontrib>BUYSE, Luk</creatorcontrib><creatorcontrib>DE SCHUTTER, Guy</creatorcontrib><creatorcontrib>MEEUSEN, Romain R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROELANDS, Bart</au><au>HASEGAWA, Hiroshi</au><au>WATSON, Phillip</au><au>PIACENTINI, Maria Francesca</au><au>BUYSE, Luk</au><au>DE SCHUTTER, Guy</au><au>MEEUSEN, Romain R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Acute Dopamine Reuptake Inhibition on Performance</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2008-05-01</date><risdate>2008</risdate><volume>40</volume><issue>5</issue><spage>879</spage><epage>885</epage><pages>879-885</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>Acute bupropion (dopamine/noradrenaline reuptake inhibitor) administration significantly improved time trial performance and increased core temperature in the heat (30 degrees C).
The present study was performed to examine the effect of a dopaminergic reuptake inhibitor on exercise capacity and thermoregulation during prolonged exercise in temperate and warm conditions.
Eight healthy well-trained male cyclists participated in this study. Subjects ingested either placebo (PLA; 20 mg) or methylphenidate (MPH; Ritalin; 20 mg) 1 h before the start of exercise in temperate (18 degrees C) or warm (30 degrees C) conditions and cycled for 60 min at 55% Wmax, immediately followed by a time trial (TT; PLA18 and MPH18; PLA30 and MPH30) to measure exercise performance.
MPH did not influence TT performance at 18 degrees C (P = 0.397). TT was completed 16% faster in MPH30 (38.1 +/- 6.4 min) than in PLA30 (45.4 +/- 7.3 min; P = 0.049). In the heat Tcore was significantly higher at rest (P = 0.009), and throughout the TT in MPH30 (P < 0.018), reaching values above 40 degrees C. Throughout MPH30, heart rates were significantly higher (P < 0.05).
These results show that MPH has a clear ergogenic effect that was not apparent in 18 degrees C. The combination of a dopamine reuptake inhibitor and exercise in the heat clearly improved performance and caused hyperthermia without any change in the perception of effort or thermal stress compared with the PLA trial. This response may potentially increase the risk of developing heat illness during exercise in individuals taking drugs of this nature.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>18408610</pmid><doi>10.1249/mss.0b013e3181659c4d</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine and science in sports and exercise, 2008-05, Vol.40 (5), p.879-885 |
| issn | 0195-9131 1530-0315 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete |
| subjects | Adult Analysis of Variance Biological and medical sciences Body Temperature Regulation - drug effects Body Temperature Regulation - physiology Cross-Over Studies Dopamine - metabolism Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Double-Blind Method Exercise - physiology Fundamental and applied biological sciences. Psychology Heart Rate - physiology Hot Temperature Humans Male Methylphenidate - administration & dosage Methylphenidate - pharmacology Space life sciences Time Factors Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | The Effects of Acute Dopamine Reuptake Inhibition on Performance |
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