Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists

New polysubstituted tetrahydronaphthalene derivatives were prepared as thromboxane receptor (TP-receptor) antagonists. Within this series of compounds S 18886 has been identified as an orally active, highly potent antagonist with a very long duration of action in different species.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-06, Vol.8 (11), p.1375-1380
Hauptverfasser:	CIMETIERE, B, DUBUFFET, T, MULLER, O, DESCOMBES, J.-J, SIMONET, S, LAUBIE, M, VERBEUREN, T. J, LAVIELLE, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiovascular system Guinea Pigs Humans In Vitro Techniques Medical sciences Miscellaneous Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Pharmacology. Drug treatments Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology Pressure Rabbits Receptors, Thromboxane - antagonists & inhibitors Stereoisomerism Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - pharmacology Tetrahydronaphthalenes - chemical synthesis Tetrahydronaphthalenes - pharmacology Trachea - drug effects Trachea - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!