Enzymatic fucosylations of non-natural sialylated type-I trisaccharides with recombinant fucosyl-transferase-III

Recombinant fucosyl-transferase-III (Lewis type enzyme) is used to prepare a series of non-natural sialyl-Lewis a derivatives on a preparative scale. The enzyme tolerates a wide range of acceptors which have the natural N-acetyl group of the glucosamine moiety replaced by substituted aromatic and he...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-01, Vol.8 (2), p.161-164
Hauptverfasser:	Baisch, Gabi, Öhrlein, Reinhold, Streiff, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Carbohydrate Sequence Fucosyltransferases - chemistry Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Molecular Sequence Data N-Acetylneuraminic Acid - chemistry Oligosaccharides - chemistry Recombinant Proteins - chemistry
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