Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction

This study describes an efficient method using on-line solid-phase extraction (SPE) (Oasis ® HLB) for preparative HPLC purification of short-lived radiotracers for positron emission tomography (PET) and for HPLC analysis of radiotracers and their metabolites in cell homogenates, plasma and urine sam...

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Veröffentlicht in:	Journal of Chromatography A 2008-05, Vol.1189 (1), p.323-331
Hauptverfasser:	Chitneni, Satish K., Serdons, Kim, Evens, Nele, Fonge, Humphrey, Celen, Sofie, Deroose, Christophe M., Debyser, Zeger, Mortelmans, Luc, Verbruggen, Alfons M., Bormans, Guy M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Contrast media. Radiopharmaceuticals Humans Medical sciences Metabolite analysis Mice Molecular Structure Oasis ® HLB column On-line solid-phase extraction Pharmacology. Drug treatments Positron-Emission Tomography Radioisotopes - administration & dosage Radioisotopes - blood Radioisotopes - isolation & purification Radiotracer Solid Phase Extraction - methods
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