BIBP 3226 inhibition of nicotinic receptor mediated chromaffin cell secretion

( R)- N 2-(diphenacetyl)- N-[(4-hydroxyphenyl)methyl]-argininamide (BIBP 3226) is a selective neuropeptide Y Y 1 receptor antagonist with structural similarity to the C-terminal tripeptide of neuropeptide Y. Based on this similarity we questioned whether BIBP 3226 could act as an agonist. Incubation...

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Veröffentlicht in:	European journal of pharmacology 1998-12, Vol.362 (2), p.121-125
Hauptverfasser:	Zhang, Peijin, Zheng, Jialin, D. Hexum, Terry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Anti-Anxiety Agents - pharmacology Arginine - analogs & derivatives Arginine - pharmacology BIBP 3226 Biological and medical sciences Calcium - metabolism Catecholamine secretion Cattle Cells, Cultured Chromaffin cell Chromaffin Cells - drug effects Chromaffin Cells - metabolism Dimethylphenylpiperazinium Iodide - antagonists & inhibitors Dose-Response Relationship, Drug Epinephrine - metabolism Fundamental and applied biological sciences. Psychology Neuropeptide Y Nicotinic Agonists - pharmacology Nicotinic Antagonists - pharmacology Norepinephrine - metabolism Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Nicotinic - physiology Vertebrates: endocrinology
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