Triad of Severe Abdominal Pain, Inappropriate Antidiuretic Hormone Secretion, and Disseminated Varicella-Zoster Virus Infection Preceding Cutaneous Manifestations After Hematopoietic Stem Cell Transplantation: Utility of PCR for Early Recognition and Therapy

A hematopoietic stem cell transplant recipient developed abdominal pain, pneumatosis intestinalis, hepatitis, pancreatitis, and inappropriate antidiuretic hormone secretion. Blood for varicella-zoster virus (VZV) DNA polymerase chain reaction was positive. She was treated with acyclovir and subseque...

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Veröffentlicht in:The Pediatric infectious disease journal 2008-03, Vol.27 (3), p.265-268
Hauptverfasser: Rau, Rachel, Fitzhugh, Courtney D, Baird, Kristin, Cortez, Karroll J, Li, Li, Fischer, Steven H, Cowen, Edward W, Balow, James E, Walsh, Thomas J, Cohen, Jeffrey I, Wayne, Alan S
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container_end_page 268
container_issue 3
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container_title The Pediatric infectious disease journal
container_volume 27
creator Rau, Rachel
Fitzhugh, Courtney D
Baird, Kristin
Cortez, Karroll J
Li, Li
Fischer, Steven H
Cowen, Edward W
Balow, James E
Walsh, Thomas J
Cohen, Jeffrey I
Wayne, Alan S
description A hematopoietic stem cell transplant recipient developed abdominal pain, pneumatosis intestinalis, hepatitis, pancreatitis, and inappropriate antidiuretic hormone secretion. Blood for varicella-zoster virus (VZV) DNA polymerase chain reaction was positive. She was treated with acyclovir and subsequently developed VZV antigen-positive zoster. Detection of VZV DNA in blood may be useful for early diagnosis in immunocompromised hosts who present with zoster without skin lesions.
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Graft versus host reaction ; DNA, Viral - blood ; Female ; Hematopoietic Stem Cell Transplantation - adverse effects ; Herpes Zoster - diagnosis ; Herpes Zoster - drug therapy ; Herpesvirus 3, Human - isolation &amp; purification ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Medical sciences ; Pancreatitis - etiology ; Pneumatosis Cystoides Intestinalis - etiology ; Polymerase Chain Reaction - methods ; Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Herpes Zoster - diagnosis</topic><topic>Herpes Zoster - drug therapy</topic><topic>Herpesvirus 3, Human - isolation &amp; purification</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Pancreatitis - etiology</topic><topic>Pneumatosis Cystoides Intestinalis - etiology</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Transfusions. Complications. Transfusion reactions. 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subjects Abdominal Pain - etiology
Acyclovir - therapeutic use
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antiviral Agents - therapeutic use
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
DNA, Viral - blood
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Herpes Zoster - diagnosis
Herpes Zoster - drug therapy
Herpesvirus 3, Human - isolation & purification
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Pancreatitis - etiology
Pneumatosis Cystoides Intestinalis - etiology
Polymerase Chain Reaction - methods
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Vasopressins - blood
title Triad of Severe Abdominal Pain, Inappropriate Antidiuretic Hormone Secretion, and Disseminated Varicella-Zoster Virus Infection Preceding Cutaneous Manifestations After Hematopoietic Stem Cell Transplantation: Utility of PCR for Early Recognition and Therapy
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