Synthesis and pharmacological activities of 13-Dehydro derivatives of primary prostaglandins
13-Dehydro derivatives of prostaglandin E 1, E 2, E 3, F 1α and F 2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-06, Vol.8 (12), p.1507-1510 |
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| container_issue | 12 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Tanami, Tohru Kameo, Kazuya Ono, Naoya Nakagawa, Takashi Annou, Shigesato Tsuboi, Mie Tani, Kousuke Okamoto, Sentaro Sato, Fumie |
| description | 13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostagladins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum. |
| doi_str_mv | 10.1016/S0960-894X(98)00247-9 |
| format | Article |
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1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostagladins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(98)00247-9</identifier><identifier>PMID: 9873379</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>agonists ; Animals ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Guinea Pigs ; Humans ; Ileum - drug effects ; Ileum - physiology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Muscle ; Muscle Contraction - drug effects ; Pharmacology. Drug treatments ; Platelet Aggregation Inhibitors - chemical synthesis ; Platelet Aggregation Inhibitors - pharmacology ; prostaglandins ; Prostaglandins - chemical synthesis ; Prostaglandins - chemistry ; Prostaglandins - pharmacology</subject><ispartof>Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (12), p.1507-1510</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-ac0e5d67c6660b047abc27a3bbf865291e4efa0114661616a7ff38c5b93201393</citedby><cites>FETCH-LOGICAL-c455t-ac0e5d67c6660b047abc27a3bbf865291e4efa0114661616a7ff38c5b93201393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-894X(98)00247-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2296954$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9873379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanami, Tohru</creatorcontrib><creatorcontrib>Kameo, Kazuya</creatorcontrib><creatorcontrib>Ono, Naoya</creatorcontrib><creatorcontrib>Nakagawa, Takashi</creatorcontrib><creatorcontrib>Annou, Shigesato</creatorcontrib><creatorcontrib>Tsuboi, Mie</creatorcontrib><creatorcontrib>Tani, Kousuke</creatorcontrib><creatorcontrib>Okamoto, Sentaro</creatorcontrib><creatorcontrib>Sato, Fumie</creatorcontrib><title>Synthesis and pharmacological activities of 13-Dehydro derivatives of primary prostaglandins</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostagladins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.</description><subject>agonists</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Ileum - drug effects</subject><subject>Ileum - physiology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Muscle</subject><subject>Muscle Contraction - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Aggregation Inhibitors - chemical synthesis</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>prostaglandins</subject><subject>Prostaglandins - chemical synthesis</subject><subject>Prostaglandins - chemistry</subject><subject>Prostaglandins - pharmacology</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOj5-gtCFiC6qN02aNiuR8QmCi1FwIYQ0vZ2JdNox6QzMvzczLbOVLO7inHvPyUfIOYUbClTcTkAKiHPJv65kfg2Q8CyWe2REueAx45Duk9HOckSOvf8BoBw4PySHMs8Yy-SIfE_WTTdDb32kmzJazLSba9PW7dQaXUfadHZlO4s-aquIsvgBZ-vStVGJzq50EHtl4excu3WYre_0tA63bONPyUGla49nwzwhn0-PH-OX-O39-XV8_xYbnqZdrA1gWorMCCGgAJ7pwiSZZkVR5SJNJEWOlQYafiZoeDqrKpabtJAsAcokOyGX_d0Q_7tE36m59QbrUAPbpVdCht0cIBjT3mhCT--wUkNxRUFtqKotVbVBpmSutlTVJuB8CFgWcyx3WwPGoF8MuvYBW-V0Y6zf2ZJECpnyYLvrbRhgrCw65Y3FxmBpHZpOla39p8gfcFOVIg</recordid><startdate>19980616</startdate><enddate>19980616</enddate><creator>Tanami, Tohru</creator><creator>Kameo, Kazuya</creator><creator>Ono, Naoya</creator><creator>Nakagawa, Takashi</creator><creator>Annou, Shigesato</creator><creator>Tsuboi, Mie</creator><creator>Tani, Kousuke</creator><creator>Okamoto, Sentaro</creator><creator>Sato, Fumie</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980616</creationdate><title>Synthesis and pharmacological activities of 13-Dehydro derivatives of primary prostaglandins</title><author>Tanami, Tohru ; Kameo, Kazuya ; Ono, Naoya ; Nakagawa, Takashi ; Annou, Shigesato ; Tsuboi, Mie ; Tani, Kousuke ; Okamoto, Sentaro ; Sato, Fumie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-ac0e5d67c6660b047abc27a3bbf865291e4efa0114661616a7ff38c5b93201393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>agonists</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Ileum - drug effects</topic><topic>Ileum - physiology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Muscle</topic><topic>Muscle Contraction - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Aggregation Inhibitors - chemical synthesis</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>prostaglandins</topic><topic>Prostaglandins - chemical synthesis</topic><topic>Prostaglandins - chemistry</topic><topic>Prostaglandins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanami, Tohru</creatorcontrib><creatorcontrib>Kameo, Kazuya</creatorcontrib><creatorcontrib>Ono, Naoya</creatorcontrib><creatorcontrib>Nakagawa, Takashi</creatorcontrib><creatorcontrib>Annou, Shigesato</creatorcontrib><creatorcontrib>Tsuboi, Mie</creatorcontrib><creatorcontrib>Tani, Kousuke</creatorcontrib><creatorcontrib>Okamoto, Sentaro</creatorcontrib><creatorcontrib>Sato, Fumie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanami, Tohru</au><au>Kameo, Kazuya</au><au>Ono, Naoya</au><au>Nakagawa, Takashi</au><au>Annou, Shigesato</au><au>Tsuboi, Mie</au><au>Tani, Kousuke</au><au>Okamoto, Sentaro</au><au>Sato, Fumie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and pharmacological activities of 13-Dehydro derivatives of primary prostaglandins</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>1998-06-16</date><risdate>1998</risdate><volume>8</volume><issue>12</issue><spage>1507</spage><epage>1510</epage><pages>1507-1510</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.
13-Dehydro derivatives of prostaglandin E
1, E
2, E
3, F
1α and F
2α were synthesized. Compared with natural prostagladins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873379</pmid><doi>10.1016/S0960-894X(98)00247-9</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (12), p.1507-1510 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69114800 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | agonists Animals Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Guinea Pigs Humans Ileum - drug effects Ileum - physiology Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Muscle Muscle Contraction - drug effects Pharmacology. Drug treatments Platelet Aggregation Inhibitors - chemical synthesis Platelet Aggregation Inhibitors - pharmacology prostaglandins Prostaglandins - chemical synthesis Prostaglandins - chemistry Prostaglandins - pharmacology |
| title | Synthesis and pharmacological activities of 13-Dehydro derivatives of primary prostaglandins |
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