New gradient high-performance liquid chromatography method for determination of donepezil hydrochloride assay and impurities content in oral pharmaceutical formulation

A new gradient HPLC method has been developed and validated for the determination of both assay and related substances of donepezil hydrochloride in oral pharmaceutical formulation. Different kinds of columns and gradient elution programs were tested in order to achieve satisfactory separation betwe...

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Veröffentlicht in:	Journal of Chromatography A 2008-05, Vol.1189 (1), p.392-397
Hauptverfasser:	Kafkala, Stella, Matthaiou, Stella, Alexaki, Pandora, Abatzis, Morfis, Bartzeliotis, Antonios, Katsiabani, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analysis Assay Biological and medical sciences Chromatography, High Pressure Liquid - methods Donepezil Drug Contamination - prevention & control General pharmacology HPLC Indans - analysis Indans - chemistry Medical sciences Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Piperidines - analysis Piperidines - chemistry Related substances Reproducibility of Results Spectrometry, Mass, Electrospray Ionization - methods
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