Mouse cytomegalovirus inhibits beta interferon (IFN-β) gene expression and controls activation pathways of the IFN-β enhanceosome

We have investigated beta interferon (IFN-beta) and IFN-alpha4 gene expression and activation of related transcription factors in mouse cytomegalovirus (MCMV)-infected fibroblasts. mRNA analysis demonstrated an initial phase of IFN gene induction upon MCMV infection, which was followed by a sustaine...

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Veröffentlicht in:	Journal of general virology 2008-05, Vol.89 (Pt 5), p.1131-1141
Hauptverfasser:	VU THUY KHANH LE, TRILLING, Mirko, ZIMMERMANN, Albert, HENGEL, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 - metabolism Animals Biological and medical sciences Cell Nucleus - chemistry Cells, Cultured Fibroblasts - virology Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation Genetics I-kappa B Proteins - metabolism Interferon Regulatory Factor-3 - metabolism Interferon Type I - antagonists & inhibitors Interferon Type I - biosynthesis Interferon-alpha Interferon-beta - antagonists & inhibitors Interferon-beta - biosynthesis Mice Microbiology Miscellaneous Muromegalovirus - immunology NF-kappa B - metabolism NF-KappaB Inhibitor alpha Proto-Oncogene Proteins c-jun - metabolism Recombinant Proteins Transcriptional Activation Virology
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