A new class of sulfoxide surfactants derived from Tris. Synthesis and preliminary assessments of their properties

A new class of non-ionic amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins, is reported. Such surfactants were prepared in two steps : addition of alkyl or fluoroalkyl mercaptan on Tris(hydroxymethyl)acrylamidomethane (THAM) derivatives, followed by t...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-06, Vol.8 (12), p.1559-1562
Hauptverfasser:	Barthélémy, Philippe, Maurizis, Jean Claude, Lacombe, Jean Michel, Pucci, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Cell Nucleus - drug effects Fundamental and applied biological sciences. Psychology Methods. Procedures. Technologies Microsomes, Liver - drug effects Mitochondria, Liver - drug effects non-ionic surfactant Others perfluoroalkyl surfactant protein extraction Rats sulfoxide Sulfoxides - chemical synthesis Sulfoxides - chemistry Sulfoxides - pharmacology Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Tris Tromethamine - chemistry Various methods and equipments
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