On-line enantiomeric analysis using high-performance liquid chromatography in chiral separation by simulated moving bed

An automated on-line enantiomeric analysis system comprising an analytical HPLC set-up with two UV detectors sharing the same light source has been employed to monitor the internal composition profile in chiral simulated moving bed chromatography. This monitoring scheme does not use a polarimeter. U...

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Veröffentlicht in:Journal of Chromatography A 2008-05, Vol.1189 (1), p.292-301
Hauptverfasser: Araújo, João M.M., Rodrigues, Rui.C.R., Eusébio, Mário F.J., Mota, José P.B.
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Sprache:eng
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