1,2-Disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors

A series of tripeptide arginine aldehydes was synthesized by replacement of proline with 1,2-disubstituted cyclohexane derivatives in the sequence of D-MePhe-Pro-Arg-H. Based on molecular modeling, further modification of the D-MePhe residue resulted in a potent and selective thrombin inhibitor. Two...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-05, Vol.8 (10), p.1249-1254
Hauptverfasser:	Harmat, Nicholas J.S., Di Bugno, Cristina, Criscuoli, M., Giorgi, Raffaello, Lippi, Annalisa, Martinelli, Adriano, Monti, Susanna, Subissi, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Amino Acid Sequence Antithrombins - chemical synthesis Antithrombins - chemistry Antithrombins - pharmacology Arginine Binding Sites Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Cyclohexanes - chemical synthesis Cyclohexanes - chemistry Cyclohexanes - pharmacology Indicators and Reagents Kinetics Medical sciences Models, Molecular Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry Oligopeptides - pharmacology Pharmacology. Drug treatments Protein Conformation Stereoisomerism Structure-Activity Relationship Thrombin - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!