Novel euglycemic and hypolipidemic agents: Part - 2 antioxidant moiety as structural motif
Several thiazolidinediones having antioxidant moities in their structural motif have been synthesised and evaluated for their euglycemic and hypolipidemic activities. A few of them have been found to be superior to troglitazone. Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety l...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-05, Vol.8 (9), p.999-1002 |
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| creator | Reddy, K.Anji Lohray, B.B. Bhushan, Vidya Reddy, A.Sekar Kishore, P.Hari Rao, V.Venugopal Saibaba, V. Bajji, A.C. Rajesh, B.M. Reddy, K.Vivekananda Chakrabarti, Ranjan Rajagopalan, R. |
| description | Several thiazolidinediones having antioxidant moities in their structural motif have been synthesised and evaluated for their euglycemic and hypolipidemic activities. A few of them have been found to be superior to troglitazone.
Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety lead to improved antidiabetic and hypolipidemic activities compared to troglitazone. |
| doi_str_mv | 10.1016/S0960-894X(98)00159-0 |
| format | Article |
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Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety lead to improved antidiabetic and hypolipidemic activities compared to troglitazone.</description><subject>Animals</subject><subject>Antioxidants - chemical synthesis</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Drug Design</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypoglycemic Agents - chemical synthesis</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - chemical synthesis</subject><subject>Hypolipidemic Agents - chemistry</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Indicators and Reagents</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Pharmacology. 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Vitamins</topic><topic>Hypoglycemic Agents - chemical synthesis</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - chemical synthesis</topic><topic>Hypolipidemic Agents - chemistry</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Indicators and Reagents</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Pharmacology. 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A few of them have been found to be superior to troglitazone.
Insertion of -N-Me-group between chroman ring and phenoxyethyl moiety lead to improved antidiabetic and hypolipidemic activities compared to troglitazone.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9871696</pmid><doi>10.1016/S0960-894X(98)00159-0</doi><tpages>4</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 1998-05, Vol.8 (9), p.999-1002 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Drug Design General and cellular metabolism. Vitamins Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - chemistry Hypolipidemic Agents - pharmacology Indicators and Reagents Medical sciences Mice Mice, Mutant Strains Pharmacology. Drug treatments Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Triglycerides - blood |
| title | Novel euglycemic and hypolipidemic agents: Part - 2 antioxidant moiety as structural motif |
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