2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors
A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease. A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (19), p.2737-2742 |
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| container_end_page | 2742 |
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| container_issue | 19 |
| container_start_page | 2737 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 8 |
| creator | Regan, John Bruno, Joseph McGarry, Daniel Poli, Gregory Hanney, Barbara Bower, Shelly Travis, Jeffrey Sweeney, Dennis Miller, Bruce Souness, John Djuric, Stevan |
| description | A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.
A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease. |
| doi_str_mv | 10.1016/S0960-894X(98)00497-1 |
| format | Article |
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A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(98)00497-1</identifier><identifier>PMID: 9873613</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors ; Animals ; Benzimidazoles - chemical synthesis ; Benzimidazoles - metabolism ; Benzimidazoles - pharmacology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Kinetics ; Medical sciences ; Mice ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Phosphodiesterase Inhibitors - chemical synthesis ; Phosphodiesterase Inhibitors - metabolism ; Phosphodiesterase Inhibitors - pharmacology ; Rats ; Solubility ; Structure-Activity Relationship</subject><ispartof>Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2737-2742</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-650269eb084849510ec8723bb70ae26746f50920ae16c9c350771aafcfcc8dc43</citedby><cites>FETCH-LOGICAL-c389t-650269eb084849510ec8723bb70ae26746f50920ae16c9c350771aafcfcc8dc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0960894X98004971$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2424128$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9873613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regan, John</creatorcontrib><creatorcontrib>Bruno, Joseph</creatorcontrib><creatorcontrib>McGarry, Daniel</creatorcontrib><creatorcontrib>Poli, Gregory</creatorcontrib><creatorcontrib>Hanney, Barbara</creatorcontrib><creatorcontrib>Bower, Shelly</creatorcontrib><creatorcontrib>Travis, Jeffrey</creatorcontrib><creatorcontrib>Sweeney, Dennis</creatorcontrib><creatorcontrib>Miller, Bruce</creatorcontrib><creatorcontrib>Souness, John</creatorcontrib><creatorcontrib>Djuric, Stevan</creatorcontrib><title>2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.
A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.</description><subject>3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors</subject><subject>Animals</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - metabolism</subject><subject>Benzimidazoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cyclic Nucleotide Phosphodiesterases, Type 4</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphodiesterase Inhibitors - chemical synthesis</subject><subject>Phosphodiesterase Inhibitors - metabolism</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Solubility</subject><subject>Structure-Activity Relationship</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo67r6EwQPInqITtI0TbyI-A0LCqvgLaTpFCP9WJNW1F9v11326mkY5nlnhoeQfQanDJg8m4GWQJUWr8danQAInVG2QcZMSEETAekmGa-RbbIT4zsAEyDEiIy0yhLJkjE553TW57HzXd9hQQWtsXtrv75zbH587Qv701ZIcxuxOHi6vhEHvnnzue_aEHfJVmmriHurOiEvtzfPV_d0-nj3cHU5pS5RuqMyBS415qCEEjplgE5lPMnzDCxymQlZpqD50DDptEtSyDJmbelK51ThRDIhR8u989B-9Bg7U_vosKpsg20fjdSMcZDZAKZL0IU2xoClmQdf2_BtGJiFM_PnzCyEGK3MnzPDhtz-6kCf11isUytJw_xwNbfR2aoMtnE-rjEuuGBcDdjFEsNBxqfHYKLz2DgsfEDXmaL1_zzyC6EYh5o</recordid><startdate>19981006</startdate><enddate>19981006</enddate><creator>Regan, John</creator><creator>Bruno, Joseph</creator><creator>McGarry, Daniel</creator><creator>Poli, Gregory</creator><creator>Hanney, Barbara</creator><creator>Bower, Shelly</creator><creator>Travis, Jeffrey</creator><creator>Sweeney, Dennis</creator><creator>Miller, Bruce</creator><creator>Souness, John</creator><creator>Djuric, Stevan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981006</creationdate><title>2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors</title><author>Regan, John ; Bruno, Joseph ; McGarry, Daniel ; Poli, Gregory ; Hanney, Barbara ; Bower, Shelly ; Travis, Jeffrey ; Sweeney, Dennis ; Miller, Bruce ; Souness, John ; Djuric, Stevan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-650269eb084849510ec8723bb70ae26746f50920ae16c9c350771aafcfcc8dc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors</topic><topic>Animals</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - metabolism</topic><topic>Benzimidazoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cyclic Nucleotide Phosphodiesterases, Type 4</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphodiesterase Inhibitors - chemical synthesis</topic><topic>Phosphodiesterase Inhibitors - metabolism</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Rats</topic><topic>Solubility</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regan, John</creatorcontrib><creatorcontrib>Bruno, Joseph</creatorcontrib><creatorcontrib>McGarry, Daniel</creatorcontrib><creatorcontrib>Poli, Gregory</creatorcontrib><creatorcontrib>Hanney, Barbara</creatorcontrib><creatorcontrib>Bower, Shelly</creatorcontrib><creatorcontrib>Travis, Jeffrey</creatorcontrib><creatorcontrib>Sweeney, Dennis</creatorcontrib><creatorcontrib>Miller, Bruce</creatorcontrib><creatorcontrib>Souness, John</creatorcontrib><creatorcontrib>Djuric, Stevan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regan, John</au><au>Bruno, Joseph</au><au>McGarry, Daniel</au><au>Poli, Gregory</au><au>Hanney, Barbara</au><au>Bower, Shelly</au><au>Travis, Jeffrey</au><au>Sweeney, Dennis</au><au>Miller, Bruce</au><au>Souness, John</au><au>Djuric, Stevan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>1998-10-06</date><risdate>1998</risdate><volume>8</volume><issue>19</issue><spage>2737</spage><epage>2742</epage><pages>2737-2742</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.
A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9873613</pmid><doi>10.1016/S0960-894X(98)00497-1</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2737-2742 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69112067 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Benzimidazoles - chemical synthesis Benzimidazoles - metabolism Benzimidazoles - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclic Nucleotide Phosphodiesterases, Type 4 Kinetics Medical sciences Mice Oxidation-Reduction Pharmacology. Drug treatments Phosphodiesterase Inhibitors - chemical synthesis Phosphodiesterase Inhibitors - metabolism Phosphodiesterase Inhibitors - pharmacology Rats Solubility Structure-Activity Relationship |
| title | 2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors |
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