Synthesis of tools for target identification of the anti-apoptotic compound CGP 3466; Part I

Immobilized compounds for BIAcore ® studies and affinity precipitation as well as a fluorescent-labeled compound were prepared in order to identify the molecular target of the anti-apoptotic, neurorescuing compound CGP 3466 (N-methyl-N-propargyl-10-aminomethyl-dibenzo[b,f]oxepin). Immobilized compou...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1998-05, Vol.8 (10), p.1195-1200
Hauptverfasser:	Zimmermann, Kaspar, Roggo, Silvio, Kragten, Eddy, Fürst, Peter, Waldmeier, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Catecholaminergic system Chromatography, Affinity Fluorescent Dyes Hippocampus - cytology Indicators and Reagents Medical sciences Molecular Structure Neurons - cytology Neurons - drug effects Neurons - physiology Neuropharmacology Neuroprotective Agents - chemical synthesis Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Neurotransmitters. Neurotransmission. Receptors Oxepins - chemical synthesis Oxepins - chemistry Oxepins - pharmacology Pharmacology. Drug treatments Rats Selegiline - analogs & derivatives Selegiline - chemical synthesis Selegiline - chemistry Selegiline - pharmacology Structure-Activity Relationship
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