Efficacy of Recombinant Bacille Calmette-Guérin Vaccine Secreting Interleukin-15/Antigen 85B Fusion Protein in Providing Protection against Mycobacterium tuberculosis

Protection against Mycobacterium tuberculosis not only depends on CD4+ T helper type 1 (Th1) cells but, also, on CD8+ T cells. Interleukin (IL)–15 has an important function in the maintenance of memory CD8+ T cells. In the present study, we examined the efficacy of recombinant Mycobacterium bovis ba...

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Veröffentlicht in:	The Journal of infectious diseases 2008-05, Vol.197 (9), p.1263-1274
Hauptverfasser:	Tang, Ce, Yamada, Hisakata, Shibata, Kensuke, Maeda, Naoyoshi, Yoshida, Shinichi, Wajjwalku, Worawidh, Ohara, Naoya, Yamada, Takeshi, Kinoshita, Taroh, Yoshikai, Yasunobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - immunology Animals Antigens Antigens, Bacterial - administration & dosage Antigens, Bacterial - biosynthesis Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacillus calmette guerin vaccine Bacteria Bacterial Proteins - genetics Bacterial Proteins - immunology Bacteriology BCG Vaccine - administration & dosage BCG Vaccine - genetics BCG Vaccine - immunology BCG Vaccine - therapeutic use Biological and medical sciences Fundamental and applied biological sciences. Psychology Immunization Infections Infectious diseases Interleukin-15 - biosynthesis Interleukin-15 - genetics Interleukin-15 - immunology Medical sciences Memory Mice Mice, Inbred C57BL Microbiology Miscellaneous Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T lymphocytes Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis vaccine Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - immunology Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology
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