Saikosaponin b2 Induces Differentiation without Growth Inhibition in Cultured B16 Melanoma Cells

Treatment with 5 μM of saikosaponin (SS) b2 for 30 days was found to induce differentiation of B16 melanoma cells, with potentiation of expressions of melanogenesis and tyrosinase. To explore the mechanism of this effect, we observed the cell growth, cell cycle and morphology, and found that SSb2 di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell Structure and Function 1998, Vol.23(5), pp.265-272
Hauptverfasser:	Zong, Zhi-ping, Fujikawa-Yamamoto, Kohzaburo, Ota, Takahide, Guan, Xin, Murakami, Manabu, Li, Ai-li, Yamaguchi, Nobuo, Tanino, Mikio, Odashima, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - drug effects Cell Differentiation - drug effects Cell Size - drug effects differentiation Fluorescent Antibody Technique Melanins - biosynthesis melanoma Melanoma, Experimental - mortality Melanoma, Experimental - pathology Mice Monophenol Monooxygenase - metabolism Neoplasm Transplantation Oleanolic Acid - analogs & derivatives PKC saikosaponin Sapogenins - chemistry Sapogenins - pharmacology Saponins Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!