Rapid Adhesion and Spread of Non-adherent Colon Cancer Colo201 Cells Induced by the Protein Kinase Inhibitors, K252a and KT5720 and Suppression of the Adhesion by the Immunosuppressants FK506 and Cyclosporin A

We examined alterations in cell morphology and expression of adhesion molecules in response to a general protein kinase inhibitor K252a treatment of non-adherent colon adenocarcinoma Colo201 cells. K252a induced rapid cell adhesion and spreading with concomitant formation of actin stress fibers. A p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell Structure and Function 1998, Vol.23(5), pp.255-264
Hauptverfasser:	Mohri, Takashi, Kameshita, Isamu, Suzuki, Shintaro, Hioki, Koshiro, Tokunaga, Rikio, Takatani, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Carbazoles - pharmacology cell adhesion Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism cell spreading colon cancer cells Colonic Neoplasms - pathology Cyclosporine - pharmacology Cytoskeletal Proteins - pharmacology Enzyme Inhibitors - pharmacology Extracellular Matrix - pathology Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Immunosuppressive Agents - pharmacology Indole Alkaloids Indoles - pharmacology Integrins - physiology K252a KT5720 and FK506 Neoplasm Metastasis Paxillin Phosphoproteins - pharmacology Phosphorylation Protein Kinase C - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Pyrroles - pharmacology Space life sciences Sulfonamides - pharmacology Tacrolimus - pharmacology Tumor Cells, Cultured Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!