Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides
Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model. Purified porcine islets were transplanted in autoimmune (non-obese diabetic)...
Gespeichert in:
| Veröffentlicht in: | Transplantation 1998-12, Vol.66 (11), p.1558-1561 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1561 |
|---|---|
| container_issue | 11 |
| container_start_page | 1558 |
| container_title | Transplantation |
| container_volume | 66 |
| creator | SQUIERS, E. C HODELL, M TICE, D BUELOW, R |
| description | Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model.
Purified porcine islets were transplanted in autoimmune (non-obese diabetic) and non-autoimmune (streptozotocin-injected CBA or C57/Bl6) diabetic mice. Various dosing regimens of HLA-derived peptides with and without antilymphocyte therapy were administered to recipient mice. Graft rejection was determined by daily serum glucose determinations, and, at selected time points, grafts were removed to demonstrate function and provide immunohistochemical examination.
HLA-derived peptides were demonstrated to prolong graft survival in both pretransplant and posttransplant treatment regimens. This effect was increased with concomitant antilymphocyte therapy.
Further elucidation of the mechanism of action of these immunomodulatory peptides may help in the development of novel immunosuppressive protocols. |
| doi_str_mv | 10.1097/00007890-199812150-00022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69109892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17172804</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-8bce00af4b23773bff81453bf2f84b30b146fd9201779d6e71c166f20c3fc52d3</originalsourceid><addsrcrecordid>eNqFUU1v1TAQtBCofRR-ApIPVW-BXTuJ7WNVtYBUCQ5wjhxn3RolcWonr_Tf49JHe2QvI-3Mfg5jHOEjglGfoITSBio0RqPABqqSEeIV22Ej66oFDa_ZDqDGCqVUx-xtzr-KpJFKHbEjo1uDADvmv6c4xvnGriHOPHq-xOTCTDzkkVb-m-Z4k6xfed7SPuztyMPMp-CIlyQlvt5SsssDvw_rLQ_TtM0xb8uSKOewJ77QsoaB8jv2xtsx0_sDnrCfV5c_Lr5U198-f704v65cLWCtdO8IwPq6F2VP2XuvsW4KCq_rXkKPdesHIwCVMkNLCh22rRfgpHeNGOQJO3vqu6R4t1FeuylkR-NoZ4pb7h6vNtqI_wpRoRIa6iLUT0KXYs6JfLekMNn00CF0j150_7zonr3o_npRSj8cZmz9RMNz4eH5hT898DY7O_pkZxfyS_8WFTRG_gFZGZMb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17172804</pqid></control><display><type>article</type><title>Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>SQUIERS, E. C ; HODELL, M ; TICE, D ; BUELOW, R</creator><creatorcontrib>SQUIERS, E. C ; HODELL, M ; TICE, D ; BUELOW, R</creatorcontrib><description>Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model.
Purified porcine islets were transplanted in autoimmune (non-obese diabetic) and non-autoimmune (streptozotocin-injected CBA or C57/Bl6) diabetic mice. Various dosing regimens of HLA-derived peptides with and without antilymphocyte therapy were administered to recipient mice. Graft rejection was determined by daily serum glucose determinations, and, at selected time points, grafts were removed to demonstrate function and provide immunohistochemical examination.
HLA-derived peptides were demonstrated to prolong graft survival in both pretransplant and posttransplant treatment regimens. This effect was increased with concomitant antilymphocyte therapy.
Further elucidation of the mechanism of action of these immunomodulatory peptides may help in the development of novel immunosuppressive protocols.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/00007890-199812150-00022</identifier><identifier>PMID: 9869100</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adjuvants, Immunologic - therapeutic use ; Animals ; Antilymphocyte Serum - therapeutic use ; Biological and medical sciences ; Graft Survival - drug effects ; Heme Oxygenase (Decyclizing) - physiology ; Histocompatibility Antigens - therapeutic use ; Immunomodulators ; Immunosuppressive Agents - therapeutic use ; Islets of Langerhans Transplantation - immunology ; Medical sciences ; Mice ; Mice, Inbred CBA ; Mice, Inbred NOD ; Pharmacology. Drug treatments ; Swine ; Transplantation, Heterologous ; Up-Regulation</subject><ispartof>Transplantation, 1998-12, Vol.66 (11), p.1558-1561</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-8bce00af4b23773bff81453bf2f84b30b146fd9201779d6e71c166f20c3fc52d3</citedby><cites>FETCH-LOGICAL-c420t-8bce00af4b23773bff81453bf2f84b30b146fd9201779d6e71c166f20c3fc52d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1617059$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9869100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SQUIERS, E. C</creatorcontrib><creatorcontrib>HODELL, M</creatorcontrib><creatorcontrib>TICE, D</creatorcontrib><creatorcontrib>BUELOW, R</creatorcontrib><title>Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model.
Purified porcine islets were transplanted in autoimmune (non-obese diabetic) and non-autoimmune (streptozotocin-injected CBA or C57/Bl6) diabetic mice. Various dosing regimens of HLA-derived peptides with and without antilymphocyte therapy were administered to recipient mice. Graft rejection was determined by daily serum glucose determinations, and, at selected time points, grafts were removed to demonstrate function and provide immunohistochemical examination.
HLA-derived peptides were demonstrated to prolong graft survival in both pretransplant and posttransplant treatment regimens. This effect was increased with concomitant antilymphocyte therapy.
Further elucidation of the mechanism of action of these immunomodulatory peptides may help in the development of novel immunosuppressive protocols.</description><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Animals</subject><subject>Antilymphocyte Serum - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Graft Survival - drug effects</subject><subject>Heme Oxygenase (Decyclizing) - physiology</subject><subject>Histocompatibility Antigens - therapeutic use</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Islets of Langerhans Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Inbred NOD</subject><subject>Pharmacology. Drug treatments</subject><subject>Swine</subject><subject>Transplantation, Heterologous</subject><subject>Up-Regulation</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1TAQtBCofRR-ApIPVW-BXTuJ7WNVtYBUCQ5wjhxn3RolcWonr_Tf49JHe2QvI-3Mfg5jHOEjglGfoITSBio0RqPABqqSEeIV22Ej66oFDa_ZDqDGCqVUx-xtzr-KpJFKHbEjo1uDADvmv6c4xvnGriHOPHq-xOTCTDzkkVb-m-Z4k6xfed7SPuztyMPMp-CIlyQlvt5SsssDvw_rLQ_TtM0xb8uSKOewJ77QsoaB8jv2xtsx0_sDnrCfV5c_Lr5U198-f704v65cLWCtdO8IwPq6F2VP2XuvsW4KCq_rXkKPdesHIwCVMkNLCh22rRfgpHeNGOQJO3vqu6R4t1FeuylkR-NoZ4pb7h6vNtqI_wpRoRIa6iLUT0KXYs6JfLekMNn00CF0j150_7zonr3o_npRSj8cZmz9RMNz4eH5hT898DY7O_pkZxfyS_8WFTRG_gFZGZMb</recordid><startdate>19981215</startdate><enddate>19981215</enddate><creator>SQUIERS, E. C</creator><creator>HODELL, M</creator><creator>TICE, D</creator><creator>BUELOW, R</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19981215</creationdate><title>Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides</title><author>SQUIERS, E. C ; HODELL, M ; TICE, D ; BUELOW, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-8bce00af4b23773bff81453bf2f84b30b146fd9201779d6e71c166f20c3fc52d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Animals</topic><topic>Antilymphocyte Serum - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Graft Survival - drug effects</topic><topic>Heme Oxygenase (Decyclizing) - physiology</topic><topic>Histocompatibility Antigens - therapeutic use</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Islets of Langerhans Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Inbred NOD</topic><topic>Pharmacology. Drug treatments</topic><topic>Swine</topic><topic>Transplantation, Heterologous</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SQUIERS, E. C</creatorcontrib><creatorcontrib>HODELL, M</creatorcontrib><creatorcontrib>TICE, D</creatorcontrib><creatorcontrib>BUELOW, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SQUIERS, E. C</au><au>HODELL, M</au><au>TICE, D</au><au>BUELOW, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1998-12-15</date><risdate>1998</risdate><volume>66</volume><issue>11</issue><spage>1558</spage><epage>1561</epage><pages>1558-1561</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Recently, peptides derived from the heavy chain of HLA-B2702 have been shown to modulate immune responses. In this study, we examined the use of these peptides for immunosuppression in a pig to mouse islet xenograft model.
Purified porcine islets were transplanted in autoimmune (non-obese diabetic) and non-autoimmune (streptozotocin-injected CBA or C57/Bl6) diabetic mice. Various dosing regimens of HLA-derived peptides with and without antilymphocyte therapy were administered to recipient mice. Graft rejection was determined by daily serum glucose determinations, and, at selected time points, grafts were removed to demonstrate function and provide immunohistochemical examination.
HLA-derived peptides were demonstrated to prolong graft survival in both pretransplant and posttransplant treatment regimens. This effect was increased with concomitant antilymphocyte therapy.
Further elucidation of the mechanism of action of these immunomodulatory peptides may help in the development of novel immunosuppressive protocols.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>9869100</pmid><doi>10.1097/00007890-199812150-00022</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1998-12, Vol.66 (11), p.1558-1561 |
| issn | 0041-1337 1534-6080 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69109892 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adjuvants, Immunologic - therapeutic use Animals Antilymphocyte Serum - therapeutic use Biological and medical sciences Graft Survival - drug effects Heme Oxygenase (Decyclizing) - physiology Histocompatibility Antigens - therapeutic use Immunomodulators Immunosuppressive Agents - therapeutic use Islets of Langerhans Transplantation - immunology Medical sciences Mice Mice, Inbred CBA Mice, Inbred NOD Pharmacology. Drug treatments Swine Transplantation, Heterologous Up-Regulation |
| title | Prolongation of porcine islet xenograft survival in mice after therapy with immunosuppressive peptides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T06%3A33%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prolongation%20of%20porcine%20islet%20xenograft%20survival%20in%20mice%20after%20therapy%20with%20immunosuppressive%20peptides&rft.jtitle=Transplantation&rft.au=SQUIERS,%20E.%20C&rft.date=1998-12-15&rft.volume=66&rft.issue=11&rft.spage=1558&rft.epage=1561&rft.pages=1558-1561&rft.issn=0041-1337&rft.eissn=1534-6080&rft.coden=TRPLAU&rft_id=info:doi/10.1097/00007890-199812150-00022&rft_dat=%3Cproquest_cross%3E17172804%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17172804&rft_id=info:pmid/9869100&rfr_iscdi=true |