Different dorsal horn neurons responding to histamine and allergic itch stimuli
We examined whether different itch signals converge on the same dorsal horn neurons in mice. Intradermal injections of histamine and SLIGRL-NH2 (protease-activated receptor-2 agonist) induced scratching in naive mice and so did mosquito allergen in sensitized mice. These stimuli induced Fos expressi...
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| Veröffentlicht in: | Neuroreport 2008-05, Vol.19 (7), p.723-726 |
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| creator | Nakano, Tasuku Andoh, Tsugunobu Lee, Jung-Bum Kuraishi, Yasushi |
| description | We examined whether different itch signals converge on the same dorsal horn neurons in mice. Intradermal injections of histamine and SLIGRL-NH2 (protease-activated receptor-2 agonist) induced scratching in naive mice and so did mosquito allergen in sensitized mice. These stimuli induced Fos expression in cells in the superficial dorsal horn. Fos-positive cells were mainly distributed within the isolectin B4-labeled region (inner aspect of lamina II) after histamine injection. In contrast, they were in the region dorsal to the isolectin B4-labeled region after injections of SLIGRL-NH2 and mosquito allergen. These results suggest that allergic itch signal is mediated by primary afferents expressing protease-activated receptor-2 and the neurons receiving signals of protease-associated itch and allergy-associated itch are different from those of histamine-induced itch. |
| doi_str_mv | 10.1097/WNR.0b013e3282fdf6c5 |
| format | Article |
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Intradermal injections of histamine and SLIGRL-NH2 (protease-activated receptor-2 agonist) induced scratching in naive mice and so did mosquito allergen in sensitized mice. These stimuli induced Fos expression in cells in the superficial dorsal horn. Fos-positive cells were mainly distributed within the isolectin B4-labeled region (inner aspect of lamina II) after histamine injection. In contrast, they were in the region dorsal to the isolectin B4-labeled region after injections of SLIGRL-NH2 and mosquito allergen. These results suggest that allergic itch signal is mediated by primary afferents expressing protease-activated receptor-2 and the neurons receiving signals of protease-associated itch and allergy-associated itch are different from those of histamine-induced itch.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e3282fdf6c5</identifier><identifier>PMID: 18418246</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Afferent Pathways - cytology ; Afferent Pathways - metabolism ; Animals ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Fundamental and applied biological sciences. Psychology ; Histamine - pharmacology ; Hypersensitivity - metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred ICR ; Posterior Horn Cells - cytology ; Posterior Horn Cells - metabolism ; Proto-Oncogene Proteins c-fos - metabolism ; Pruritus - etiology ; Pruritus - metabolism ; Receptor, PAR-2 - metabolism ; Skin - innervation ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2008-05, Vol.19 (7), p.723-726</ispartof><rights>2008 Lippincott Williams & Wilkins, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4114-82ec3f832b02b91d8627ec428ef97de2f2ea8730c775b9af9072817996c14fa43</citedby><cites>FETCH-LOGICAL-c4114-82ec3f832b02b91d8627ec428ef97de2f2ea8730c775b9af9072817996c14fa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20267575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18418246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakano, Tasuku</creatorcontrib><creatorcontrib>Andoh, Tsugunobu</creatorcontrib><creatorcontrib>Lee, Jung-Bum</creatorcontrib><creatorcontrib>Kuraishi, Yasushi</creatorcontrib><title>Different dorsal horn neurons responding to histamine and allergic itch stimuli</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>We examined whether different itch signals converge on the same dorsal horn neurons in mice. Intradermal injections of histamine and SLIGRL-NH2 (protease-activated receptor-2 agonist) induced scratching in naive mice and so did mosquito allergen in sensitized mice. These stimuli induced Fos expression in cells in the superficial dorsal horn. Fos-positive cells were mainly distributed within the isolectin B4-labeled region (inner aspect of lamina II) after histamine injection. In contrast, they were in the region dorsal to the isolectin B4-labeled region after injections of SLIGRL-NH2 and mosquito allergen. 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Psychology</subject><subject>Histamine - pharmacology</subject><subject>Hypersensitivity - metabolism</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Posterior Horn Cells - cytology</subject><subject>Posterior Horn Cells - metabolism</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Pruritus - etiology</subject><subject>Pruritus - metabolism</subject><subject>Receptor, PAR-2 - metabolism</subject><subject>Skin - innervation</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFTEQhoMo9lj9ByK50bttJ9lkk1xK6xeUFkTRu5DNTrrRbPaY7FL6793Sg4o3vRoYnvcdeIaQlwxOGBh1-u3y8wn0wFpsueZhCJ2Xj8iOCdU2Uurvj8kOjDSNMJ08Is9q_QEABph-So6YFkxz0e3I1XkMAQvmhQ5zqS7RcS6ZZlzLnCstWPdzHmK-pstMx1gXN8WM1OWBupSwXEdP4-JHWpc4rSk-J0-CSxVfHOYx-fr-3Zezj83F1YdPZ28vGi8YE43m6NugW94D7w0bdMcVesE1BqMG5IGj06oFr5TsjQsGFNdMGdN5JoIT7TF5c9-7L_OvFetip1g9puQyzmu1ndkkCQYPghwkN1rLDRT3oC9zrQWD3Zc4uXJrGdg743Yzbv83vsVeHfrXfsLhb-igeANeHwBXvUuhuOxj_cNx4J2S6p_7N3NasNSfab3BYkd0aRnt9jtgSnYNB9AgQUFztxLtb71amrg</recordid><startdate>20080507</startdate><enddate>20080507</enddate><creator>Nakano, Tasuku</creator><creator>Andoh, Tsugunobu</creator><creator>Lee, Jung-Bum</creator><creator>Kuraishi, Yasushi</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080507</creationdate><title>Different dorsal horn neurons responding to histamine and allergic itch stimuli</title><author>Nakano, Tasuku ; Andoh, Tsugunobu ; Lee, Jung-Bum ; Kuraishi, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4114-82ec3f832b02b91d8627ec428ef97de2f2ea8730c775b9af9072817996c14fa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Afferent Pathways - cytology</topic><topic>Afferent Pathways - metabolism</topic><topic>Animals</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histamine - pharmacology</topic><topic>Hypersensitivity - metabolism</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Posterior Horn Cells - cytology</topic><topic>Posterior Horn Cells - metabolism</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Pruritus - etiology</topic><topic>Pruritus - metabolism</topic><topic>Receptor, PAR-2 - metabolism</topic><topic>Skin - innervation</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakano, Tasuku</creatorcontrib><creatorcontrib>Andoh, Tsugunobu</creatorcontrib><creatorcontrib>Lee, Jung-Bum</creatorcontrib><creatorcontrib>Kuraishi, Yasushi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakano, Tasuku</au><au>Andoh, Tsugunobu</au><au>Lee, Jung-Bum</au><au>Kuraishi, Yasushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different dorsal horn neurons responding to histamine and allergic itch stimuli</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2008-05-07</date><risdate>2008</risdate><volume>19</volume><issue>7</issue><spage>723</spage><epage>726</epage><pages>723-726</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>We examined whether different itch signals converge on the same dorsal horn neurons in mice. Intradermal injections of histamine and SLIGRL-NH2 (protease-activated receptor-2 agonist) induced scratching in naive mice and so did mosquito allergen in sensitized mice. These stimuli induced Fos expression in cells in the superficial dorsal horn. Fos-positive cells were mainly distributed within the isolectin B4-labeled region (inner aspect of lamina II) after histamine injection. In contrast, they were in the region dorsal to the isolectin B4-labeled region after injections of SLIGRL-NH2 and mosquito allergen. These results suggest that allergic itch signal is mediated by primary afferents expressing protease-activated receptor-2 and the neurons receiving signals of protease-associated itch and allergy-associated itch are different from those of histamine-induced itch.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>18418246</pmid><doi>10.1097/WNR.0b013e3282fdf6c5</doi><tpages>4</tpages></addata></record> |
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| subjects | Afferent Pathways - cytology Afferent Pathways - metabolism Animals Biochemistry and metabolism Biological and medical sciences Central nervous system Fundamental and applied biological sciences. Psychology Histamine - pharmacology Hypersensitivity - metabolism Immunohistochemistry Mice Mice, Inbred ICR Posterior Horn Cells - cytology Posterior Horn Cells - metabolism Proto-Oncogene Proteins c-fos - metabolism Pruritus - etiology Pruritus - metabolism Receptor, PAR-2 - metabolism Skin - innervation Vertebrates: nervous system and sense organs |
| title | Different dorsal horn neurons responding to histamine and allergic itch stimuli |
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