Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution
Purpose: To determine the efficacy of definitive surgery and radiation in patients aged 70 years and older with supratentorial glioblastoma multiforme. Methods and Materials: We selected elderly patients (≥ 70 years) who had primary treatment for glioblastoma multiforme at our tertiary care institut...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1998-12, Vol.42 (5), p.981-987 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Mohan, Dasarahally S Suh, John H Phan, Jennifer L Kupelian, Patrick A Cohen, Bruce H Barnett, Gene H |
| description | Purpose: To determine the efficacy of definitive surgery and radiation in patients aged 70 years and older with supratentorial glioblastoma multiforme.
Methods and Materials: We selected elderly patients (≥ 70 years) who had primary treatment for glioblastoma multiforme at our tertiary care institution from 1977 through 1996. The study group (n = 102) included 58 patients treated with definitive radiation, 19 treated with palliative radiation, and 25 who received no radiation. To compare our results with published findings, we grouped our patients according to the applicable prognostic categories developed by the Radiation Therapy Oncology Group (RTOG): RTOG group IV (n = 6), V (n = 70), and VI (n = 26). Patients were retrospectively assigned to prognostic group IV, V, or VI based on age, performance status, extent of surgery, mental status, neurologic function, and radiation dose. Treatment included surgical resection and radiation (n = 49), biopsy alone (n = 25), and biopsy followed by radiation (n = 28). Patients were also stratified according to whether they were optimally treated (gross total or subtotal resection with postoperative definitive radiation) or suboptimally treated (biopsy, biopsy + radiation, surgery alone, or surgery + palliative radiation). Patients were considered to have a favorable prognosis (n = 39) if they were optimally treated and had a Karnofsky Performance Status (KPS) score of at least 70.
Results: The median survival for patients according to RTOG groups IV, V, and VI was 9.2, 6.6, and 3.1 months, respectively (log-rank, p < 0.0004). The median overall survival was 5.3 months. The definitive radiation group (n = 58) had a median survival of 7.3 months compared to 4.5 months in the palliative radiation group (n = 19) and 1.2 months in the biopsy-alone group (p < 0.0001). Optimally treated patients had a median survival of 7.4 months compared to 2.4 months in those suboptimally treated (p < 0.0001). The favorable prognosis group had an 8.4-month median survival compared to 2.4 months in the unfavorable group (p < 0.0001). On multivariate analysis, the KPS, RTOG group, favorable/unfavorable prognosis, and optimal treatment/suboptimal treatment were significant predictors of survival.
Conclusion: Elderly patients with good performance status (≥ 70 KPS) when treated aggressively with maximal resection and definitive radiation had longer survival than those treated with palliative radiation and biopsy. Aggressive treatment in such |
| doi_str_mv | 10.1016/S0360-3016(98)00296-X |
| format | Article |
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Methods and Materials: We selected elderly patients (≥ 70 years) who had primary treatment for glioblastoma multiforme at our tertiary care institution from 1977 through 1996. The study group (n = 102) included 58 patients treated with definitive radiation, 19 treated with palliative radiation, and 25 who received no radiation. To compare our results with published findings, we grouped our patients according to the applicable prognostic categories developed by the Radiation Therapy Oncology Group (RTOG): RTOG group IV (n = 6), V (n = 70), and VI (n = 26). Patients were retrospectively assigned to prognostic group IV, V, or VI based on age, performance status, extent of surgery, mental status, neurologic function, and radiation dose. Treatment included surgical resection and radiation (n = 49), biopsy alone (n = 25), and biopsy followed by radiation (n = 28). Patients were also stratified according to whether they were optimally treated (gross total or subtotal resection with postoperative definitive radiation) or suboptimally treated (biopsy, biopsy + radiation, surgery alone, or surgery + palliative radiation). Patients were considered to have a favorable prognosis (n = 39) if they were optimally treated and had a Karnofsky Performance Status (KPS) score of at least 70.
Results: The median survival for patients according to RTOG groups IV, V, and VI was 9.2, 6.6, and 3.1 months, respectively (log-rank, p < 0.0004). The median overall survival was 5.3 months. The definitive radiation group (n = 58) had a median survival of 7.3 months compared to 4.5 months in the palliative radiation group (n = 19) and 1.2 months in the biopsy-alone group (p < 0.0001). Optimally treated patients had a median survival of 7.4 months compared to 2.4 months in those suboptimally treated (p < 0.0001). The favorable prognosis group had an 8.4-month median survival compared to 2.4 months in the unfavorable group (p < 0.0001). On multivariate analysis, the KPS, RTOG group, favorable/unfavorable prognosis, and optimal treatment/suboptimal treatment were significant predictors of survival.
Conclusion: Elderly patients with good performance status (≥ 70 KPS) when treated aggressively with maximal resection and definitive radiation had longer survival than those treated with palliative radiation and biopsy. Aggressive treatment in such patients should be considered.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/S0360-3016(98)00296-X</identifier><identifier>PMID: 9869219</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Combined Modality Therapy ; Elderly patients ; Female ; Glioblastoma - drug therapy ; Glioblastoma - mortality ; Glioblastoma - radiotherapy ; Glioblastoma - surgery ; Glioblastoma multiforme ; Humans ; Karnofsky Performance Status ; Male ; Medical sciences ; Neurology ; Radiotherapy ; Retrospective Studies ; Supratentorial Neoplasms - drug therapy ; Supratentorial Neoplasms - mortality ; Supratentorial Neoplasms - radiotherapy ; Supratentorial Neoplasms - surgery ; Surgery ; Survival Analysis ; Treatment Outcome ; Tumors of the nervous system. Phacomatoses</subject><ispartof>International journal of radiation oncology, biology, physics, 1998-12, Vol.42 (5), p.981-987</ispartof><rights>1998 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-b8986064d3a13a88e05e5bea4d9d127fbaba00e66cb403d1c8bbd98ac55154273</citedby><cites>FETCH-LOGICAL-c479t-b8986064d3a13a88e05e5bea4d9d127fbaba00e66cb403d1c8bbd98ac55154273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S036030169800296X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,23910,23911,25119,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1635135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9869219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohan, Dasarahally S</creatorcontrib><creatorcontrib>Suh, John H</creatorcontrib><creatorcontrib>Phan, Jennifer L</creatorcontrib><creatorcontrib>Kupelian, Patrick A</creatorcontrib><creatorcontrib>Cohen, Bruce H</creatorcontrib><creatorcontrib>Barnett, Gene H</creatorcontrib><title>Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose: To determine the efficacy of definitive surgery and radiation in patients aged 70 years and older with supratentorial glioblastoma multiforme.
Methods and Materials: We selected elderly patients (≥ 70 years) who had primary treatment for glioblastoma multiforme at our tertiary care institution from 1977 through 1996. The study group (n = 102) included 58 patients treated with definitive radiation, 19 treated with palliative radiation, and 25 who received no radiation. To compare our results with published findings, we grouped our patients according to the applicable prognostic categories developed by the Radiation Therapy Oncology Group (RTOG): RTOG group IV (n = 6), V (n = 70), and VI (n = 26). Patients were retrospectively assigned to prognostic group IV, V, or VI based on age, performance status, extent of surgery, mental status, neurologic function, and radiation dose. Treatment included surgical resection and radiation (n = 49), biopsy alone (n = 25), and biopsy followed by radiation (n = 28). Patients were also stratified according to whether they were optimally treated (gross total or subtotal resection with postoperative definitive radiation) or suboptimally treated (biopsy, biopsy + radiation, surgery alone, or surgery + palliative radiation). Patients were considered to have a favorable prognosis (n = 39) if they were optimally treated and had a Karnofsky Performance Status (KPS) score of at least 70.
Results: The median survival for patients according to RTOG groups IV, V, and VI was 9.2, 6.6, and 3.1 months, respectively (log-rank, p < 0.0004). The median overall survival was 5.3 months. The definitive radiation group (n = 58) had a median survival of 7.3 months compared to 4.5 months in the palliative radiation group (n = 19) and 1.2 months in the biopsy-alone group (p < 0.0001). Optimally treated patients had a median survival of 7.4 months compared to 2.4 months in those suboptimally treated (p < 0.0001). The favorable prognosis group had an 8.4-month median survival compared to 2.4 months in the unfavorable group (p < 0.0001). On multivariate analysis, the KPS, RTOG group, favorable/unfavorable prognosis, and optimal treatment/suboptimal treatment were significant predictors of survival.
Conclusion: Elderly patients with good performance status (≥ 70 KPS) when treated aggressively with maximal resection and definitive radiation had longer survival than those treated with palliative radiation and biopsy. Aggressive treatment in such patients should be considered.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>Elderly patients</subject><subject>Female</subject><subject>Glioblastoma - drug therapy</subject><subject>Glioblastoma - mortality</subject><subject>Glioblastoma - radiotherapy</subject><subject>Glioblastoma - surgery</subject><subject>Glioblastoma multiforme</subject><subject>Humans</subject><subject>Karnofsky Performance Status</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Radiotherapy</subject><subject>Retrospective Studies</subject><subject>Supratentorial Neoplasms - drug therapy</subject><subject>Supratentorial Neoplasms - mortality</subject><subject>Supratentorial Neoplasms - radiotherapy</subject><subject>Supratentorial Neoplasms - surgery</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-OFCEQxonRrOPqI2zCwRg9tMLQdMPJmI3_kk32oCZzI9VQPWLopgV6k3kU31ZmZ7IePUGoX331UR8hV5y95Yx3774x0bFG1Otrrd4wttVds3tENlz1uhFS7h6TzQPylDzL-RdjjPO-vSAXWnV6y_WG_Lldi40TUj9TDA5TONAFise5ZLrO9WEf_bynDkc_--LvkOY17TEdKMyOJnC-0nGm5ScmWA50jKkSS4JSJWLyEOg--DgEyCVOQKc1FF-hOhIKBVowFQ9VzkI6usjFl_Wo-Jw8GSFkfHE-L8mPTx-_X39pbm4_f73-cNPYttelGVT9C-taJ4ALUAqZRDkgtE47vu3HAQZgDLvODi0Tjls1DE4rsFJy2W57cUlenXSXFH-vmIuZfLYYAswY12w6zZkWXFVQnkCbYs4JR7MkP1XrhjNzjMTcR2KO-zZamftIzK72XZ0HrMOE7qHrnEGtvzzXIVsIY4LZ-vxPvBOSC1mx9ycM6zLuPCaTbY3JovMJbTEu-v8Y-QsULa31</recordid><startdate>19981201</startdate><enddate>19981201</enddate><creator>Mohan, Dasarahally S</creator><creator>Suh, John H</creator><creator>Phan, Jennifer L</creator><creator>Kupelian, Patrick A</creator><creator>Cohen, Bruce H</creator><creator>Barnett, Gene H</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981201</creationdate><title>Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution</title><author>Mohan, Dasarahally S ; Suh, John H ; Phan, Jennifer L ; Kupelian, Patrick A ; Cohen, Bruce H ; Barnett, Gene H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-b8986064d3a13a88e05e5bea4d9d127fbaba00e66cb403d1c8bbd98ac55154273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>Elderly patients</topic><topic>Female</topic><topic>Glioblastoma - drug therapy</topic><topic>Glioblastoma - mortality</topic><topic>Glioblastoma - radiotherapy</topic><topic>Glioblastoma - surgery</topic><topic>Glioblastoma multiforme</topic><topic>Humans</topic><topic>Karnofsky Performance Status</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Radiotherapy</topic><topic>Retrospective Studies</topic><topic>Supratentorial Neoplasms - drug therapy</topic><topic>Supratentorial Neoplasms - mortality</topic><topic>Supratentorial Neoplasms - radiotherapy</topic><topic>Supratentorial Neoplasms - surgery</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohan, Dasarahally S</creatorcontrib><creatorcontrib>Suh, John H</creatorcontrib><creatorcontrib>Phan, Jennifer L</creatorcontrib><creatorcontrib>Kupelian, Patrick A</creatorcontrib><creatorcontrib>Cohen, Bruce H</creatorcontrib><creatorcontrib>Barnett, Gene H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohan, Dasarahally S</au><au>Suh, John H</au><au>Phan, Jennifer L</au><au>Kupelian, Patrick A</au><au>Cohen, Bruce H</au><au>Barnett, Gene H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>42</volume><issue>5</issue><spage>981</spage><epage>987</epage><pages>981-987</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Purpose: To determine the efficacy of definitive surgery and radiation in patients aged 70 years and older with supratentorial glioblastoma multiforme.
Methods and Materials: We selected elderly patients (≥ 70 years) who had primary treatment for glioblastoma multiforme at our tertiary care institution from 1977 through 1996. The study group (n = 102) included 58 patients treated with definitive radiation, 19 treated with palliative radiation, and 25 who received no radiation. To compare our results with published findings, we grouped our patients according to the applicable prognostic categories developed by the Radiation Therapy Oncology Group (RTOG): RTOG group IV (n = 6), V (n = 70), and VI (n = 26). Patients were retrospectively assigned to prognostic group IV, V, or VI based on age, performance status, extent of surgery, mental status, neurologic function, and radiation dose. Treatment included surgical resection and radiation (n = 49), biopsy alone (n = 25), and biopsy followed by radiation (n = 28). Patients were also stratified according to whether they were optimally treated (gross total or subtotal resection with postoperative definitive radiation) or suboptimally treated (biopsy, biopsy + radiation, surgery alone, or surgery + palliative radiation). Patients were considered to have a favorable prognosis (n = 39) if they were optimally treated and had a Karnofsky Performance Status (KPS) score of at least 70.
Results: The median survival for patients according to RTOG groups IV, V, and VI was 9.2, 6.6, and 3.1 months, respectively (log-rank, p < 0.0004). The median overall survival was 5.3 months. The definitive radiation group (n = 58) had a median survival of 7.3 months compared to 4.5 months in the palliative radiation group (n = 19) and 1.2 months in the biopsy-alone group (p < 0.0001). Optimally treated patients had a median survival of 7.4 months compared to 2.4 months in those suboptimally treated (p < 0.0001). The favorable prognosis group had an 8.4-month median survival compared to 2.4 months in the unfavorable group (p < 0.0001). On multivariate analysis, the KPS, RTOG group, favorable/unfavorable prognosis, and optimal treatment/suboptimal treatment were significant predictors of survival.
Conclusion: Elderly patients with good performance status (≥ 70 KPS) when treated aggressively with maximal resection and definitive radiation had longer survival than those treated with palliative radiation and biopsy. Aggressive treatment in such patients should be considered.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9869219</pmid><doi>10.1016/S0360-3016(98)00296-X</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Combined Modality Therapy Elderly patients Female Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - radiotherapy Glioblastoma - surgery Glioblastoma multiforme Humans Karnofsky Performance Status Male Medical sciences Neurology Radiotherapy Retrospective Studies Supratentorial Neoplasms - drug therapy Supratentorial Neoplasms - mortality Supratentorial Neoplasms - radiotherapy Supratentorial Neoplasms - surgery Surgery Survival Analysis Treatment Outcome Tumors of the nervous system. Phacomatoses |
| title | Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution |
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