Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK

Objective It was reported that there are cardiac stem cells (CSCs) in the rat heart, and they could reconstitute well-differentiated myocardium that are formed by blood-carrying new vessels and myocytes. However, how do the CSCs migrate into the peri-infarcted areas after myocardial infarction (MI)?...

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Veröffentlicht in:	Basic research in cardiology 2008-05, Vol.103 (3), p.265-273
Hauptverfasser:	Kuang, Dong, Zhao, Xia, Xiao, Guixiang, Ni, Juan, Feng, Youmei, Wu, Renliang, Wang, Guoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Cardiology Cells, Cultured Chemotaxis - drug effects Disease Models, Animal Heart Ventricles - enzymology Heart Ventricles - pathology Imidazoles - pharmacology Male Medicine Medicine & Public Health Myocardial Infarction - enzymology Myocardial Infarction - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Original Contribution p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-kit - immunology Proto-Oncogene Proteins c-kit - metabolism Pyridines - pharmacology Rats Rats, Wistar RNA, Messenger - metabolism Signal Transduction - drug effects Stem Cell Factor - genetics Stem Cell Factor - metabolism Stem Cells - drug effects Stem Cells - enzymology Stem Cells - pathology Time Factors Up-Regulation
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