Selective conservation of an E-protein gene promoter during vertebrate evolution
The murine E-protein gene ME1 encodes a non-tissue-specific, helix-loop-helix transcription factor that is associated with morphological development. ME1 gene expression is regulated by a TATA-less promoter that contains multiple Sp1 consensus elements, E-boxes, and a novel transcription initiation...
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| Veröffentlicht in: | FEBS letters 1998-12, Vol.440 (3), p.332-336 |
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| creator | Shain, Daniel H. Zuber, Mauricio X. Norris, Jeff Yoo, Jakyoung Neuman, Toomas |
| description | The murine E-protein gene ME1 encodes a non-tissue-specific, helix-loop-helix transcription factor that is associated with morphological development. ME1 gene expression is regulated by a TATA-less promoter that contains multiple Sp1 consensus elements, E-boxes, and a novel transcription initiation site. In this study, we compared DNA homologous to the ME1 promoter from vertebrate species ranging from frog to human. A region of striking sequence similarity was identified in a region corresponding to the ME1 transcription initiation site (ME1 Inr). Within this region, a poly d(A) tract and a 9-bp inverted repeat (5′-GTCCGCCTG) were highly conserved in all species that were examined. Protein complexes that recognized these DNA elements were present among distant vertebrates (frog, chick, monkey and human), and were able to bend the ME1 Inr to a similar extent (∼60°) as the previously described murine MBPα and MBPβ proteins. Collectively, these results suggest that an ME1 Inr-like element and its associated proteins functioned in an ancestral vertebrate more than 350 million years ago. |
| doi_str_mv | 10.1016/S0014-5793(98)01417-3 |
| format | Article |
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ME1 gene expression is regulated by a TATA-less promoter that contains multiple Sp1 consensus elements, E-boxes, and a novel transcription initiation site. In this study, we compared DNA homologous to the ME1 promoter from vertebrate species ranging from frog to human. A region of striking sequence similarity was identified in a region corresponding to the ME1 transcription initiation site (ME1 Inr). Within this region, a poly d(A) tract and a 9-bp inverted repeat (5′-GTCCGCCTG) were highly conserved in all species that were examined. Protein complexes that recognized these DNA elements were present among distant vertebrates (frog, chick, monkey and human), and were able to bend the ME1 Inr to a similar extent (∼60°) as the previously described murine MBPα and MBPβ proteins. Collectively, these results suggest that an ME1 Inr-like element and its associated proteins functioned in an ancestral vertebrate more than 350 million years ago.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/S0014-5793(98)01417-3</identifier><identifier>PMID: 9872397</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors ; Cloning, Molecular ; Conserved Sequence ; COS Cells ; DNA - analysis ; DNA bending ; DNA-Binding Proteins - genetics ; E-protein ; Evolution, Molecular ; Gene expression ; Gene Expression Regulation ; Genomic Library ; Humans ; Mice ; Molecular Sequence Data ; Mouse ; Promoter ; Promoter Regions, Genetic ; Protein Binding ; Sequence Homology, Nucleic Acid ; Transcription Factors - genetics ; Transcription, Genetic ; Vertebrate evolution</subject><ispartof>FEBS letters, 1998-12, Vol.440 (3), p.332-336</ispartof><rights>1998 Federation of European Biochemical Societies</rights><rights>FEBS Letters 440 (1998) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4723-fb53539a426c974de89a9bceedec0e461b02a146f3aea0bb02b216550b7f173e3</citedby><cites>FETCH-LOGICAL-c4723-fb53539a426c974de89a9bceedec0e461b02a146f3aea0bb02b216550b7f173e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2898%2901417-3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-5793(98)01417-3$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9872397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shain, Daniel H.</creatorcontrib><creatorcontrib>Zuber, Mauricio X.</creatorcontrib><creatorcontrib>Norris, Jeff</creatorcontrib><creatorcontrib>Yoo, Jakyoung</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><title>Selective conservation of an E-protein gene promoter during vertebrate evolution</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The murine E-protein gene ME1 encodes a non-tissue-specific, helix-loop-helix transcription factor that is associated with morphological development. ME1 gene expression is regulated by a TATA-less promoter that contains multiple Sp1 consensus elements, E-boxes, and a novel transcription initiation site. In this study, we compared DNA homologous to the ME1 promoter from vertebrate species ranging from frog to human. A region of striking sequence similarity was identified in a region corresponding to the ME1 transcription initiation site (ME1 Inr). Within this region, a poly d(A) tract and a 9-bp inverted repeat (5′-GTCCGCCTG) were highly conserved in all species that were examined. Protein complexes that recognized these DNA elements were present among distant vertebrates (frog, chick, monkey and human), and were able to bend the ME1 Inr to a similar extent (∼60°) as the previously described murine MBPα and MBPβ proteins. Collectively, these results suggest that an ME1 Inr-like element and its associated proteins functioned in an ancestral vertebrate more than 350 million years ago.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>Cloning, Molecular</subject><subject>Conserved Sequence</subject><subject>COS Cells</subject><subject>DNA - analysis</subject><subject>DNA bending</subject><subject>DNA-Binding Proteins - genetics</subject><subject>E-protein</subject><subject>Evolution, Molecular</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genomic Library</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Mouse</subject><subject>Promoter</subject><subject>Promoter Regions, Genetic</subject><subject>Protein Binding</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transcription Factors - genetics</subject><subject>Transcription, Genetic</subject><subject>Vertebrate evolution</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUV1LwzAUDaLM-fETBnkSfagmTT-SJ9GxOWGgMH0OaXo7Il07k7ayf2_ajb3qU3Jyzj3ncoLQhJJ7SmjysCKERkGcCnYr-J2_0zRgJ2hMecoCFiX8FI2PknN04dwX8ZhTMUIjwdOQiXSM3ldQgm5MB1jXlQPbqcbUFa4LrCo8C7a2bsBUeA0VYA82Hlqct9ZUa9yBbSCzqgEMXV22_eQVOitU6eD6cF6iz_nsY7oIlm8vr9OnZaAjHx0UWcxiJlQUJlqkUQ5cKJFpgBw0gSihGQkVjZKCKVAk8ygLaRLHJEsLmjJgl-hm7-uX-m7BNXJjnIayVBXUrZOJoIRTKrww3gu1rZ2zUMitNRtld5IS2TcphyZlX5MUXA5NSubnJoeANttAfpw6VOf5xZ7_MSXs_mcq57PncGB6QvDhuY963FuBL6wzYKXTBioNubH-c2Remz-W_QUejpgB</recordid><startdate>19981204</startdate><enddate>19981204</enddate><creator>Shain, Daniel H.</creator><creator>Zuber, Mauricio X.</creator><creator>Norris, Jeff</creator><creator>Yoo, Jakyoung</creator><creator>Neuman, Toomas</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981204</creationdate><title>Selective conservation of an E-protein gene promoter during vertebrate evolution</title><author>Shain, Daniel H. ; Zuber, Mauricio X. ; Norris, Jeff ; Yoo, Jakyoung ; Neuman, Toomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4723-fb53539a426c974de89a9bceedec0e461b02a146f3aea0bb02b216550b7f173e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>Cloning, Molecular</topic><topic>Conserved Sequence</topic><topic>COS Cells</topic><topic>DNA - analysis</topic><topic>DNA bending</topic><topic>DNA-Binding Proteins - genetics</topic><topic>E-protein</topic><topic>Evolution, Molecular</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Genomic Library</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Mouse</topic><topic>Promoter</topic><topic>Promoter Regions, Genetic</topic><topic>Protein Binding</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcription Factors - genetics</topic><topic>Transcription, Genetic</topic><topic>Vertebrate evolution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shain, Daniel H.</creatorcontrib><creatorcontrib>Zuber, Mauricio X.</creatorcontrib><creatorcontrib>Norris, Jeff</creatorcontrib><creatorcontrib>Yoo, Jakyoung</creatorcontrib><creatorcontrib>Neuman, Toomas</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shain, Daniel H.</au><au>Zuber, Mauricio X.</au><au>Norris, Jeff</au><au>Yoo, Jakyoung</au><au>Neuman, Toomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective conservation of an E-protein gene promoter during vertebrate evolution</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1998-12-04</date><risdate>1998</risdate><volume>440</volume><issue>3</issue><spage>332</spage><epage>336</epage><pages>332-336</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The murine E-protein gene ME1 encodes a non-tissue-specific, helix-loop-helix transcription factor that is associated with morphological development. ME1 gene expression is regulated by a TATA-less promoter that contains multiple Sp1 consensus elements, E-boxes, and a novel transcription initiation site. In this study, we compared DNA homologous to the ME1 promoter from vertebrate species ranging from frog to human. A region of striking sequence similarity was identified in a region corresponding to the ME1 transcription initiation site (ME1 Inr). Within this region, a poly d(A) tract and a 9-bp inverted repeat (5′-GTCCGCCTG) were highly conserved in all species that were examined. Protein complexes that recognized these DNA elements were present among distant vertebrates (frog, chick, monkey and human), and were able to bend the ME1 Inr to a similar extent (∼60°) as the previously described murine MBPα and MBPβ proteins. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Wiley Blackwell Journals |
| subjects | Animals Base Sequence Basic Helix-Loop-Helix Transcription Factors Cloning, Molecular Conserved Sequence COS Cells DNA - analysis DNA bending DNA-Binding Proteins - genetics E-protein Evolution, Molecular Gene expression Gene Expression Regulation Genomic Library Humans Mice Molecular Sequence Data Mouse Promoter Promoter Regions, Genetic Protein Binding Sequence Homology, Nucleic Acid Transcription Factors - genetics Transcription, Genetic Vertebrate evolution |
| title | Selective conservation of an E-protein gene promoter during vertebrate evolution |
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