Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells
Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in...
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| Veröffentlicht in: | European journal of pharmacology 1998-11, Vol.361 (2-3), p.293-298 |
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| container_title | European journal of pharmacology |
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| creator | Gallois, A Bueb, J L Tschirhart, E |
| description | Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in the absence of extracellular Ca2+ resulted in a major reduction of [Ca2+]i rise and O2- production. A purported inhibitor of store-operated Ca2+ entry, SK&F 96365 (1-(beta-(3-(4-methoxy-phenyl)propoxyl)-4-methoxy-phenetyl)- 1H-imidazole hydrochloride), inhibited extracellular Ca2+ -dependent [Ca2+]i rise by 30% but did not alter O2- production. In conclusion, SK&F 96365 did not modify extracellular Ca2+ -dependent O2- production, despite a significant but limited reduction in fMLP-activated membrane Ca2+ fluxes which can be ascribed to store-operated Ca2+ entry. Furthermore, Ca2+ influx is necessary for a full induction and maintenance of the biological response. |
| doi_str_mv | 10.1016/s0014-2999(98)00728-6 |
| format | Article |
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Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in the absence of extracellular Ca2+ resulted in a major reduction of [Ca2+]i rise and O2- production. A purported inhibitor of store-operated Ca2+ entry, SK&F 96365 (1-(beta-(3-(4-methoxy-phenyl)propoxyl)-4-methoxy-phenetyl)- 1H-imidazole hydrochloride), inhibited extracellular Ca2+ -dependent [Ca2+]i rise by 30% but did not alter O2- production. In conclusion, SK&F 96365 did not modify extracellular Ca2+ -dependent O2- production, despite a significant but limited reduction in fMLP-activated membrane Ca2+ fluxes which can be ascribed to store-operated Ca2+ entry. Furthermore, Ca2+ influx is necessary for a full induction and maintenance of the biological response.</description><identifier>ISSN: 0014-2999</identifier><identifier>DOI: 10.1016/s0014-2999(98)00728-6</identifier><identifier>PMID: 9865520</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; HL-60 Cells ; Humans ; Imidazoles - pharmacology ; Manganese - metabolism ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Neutrophils - drug effects ; Neutrophils - metabolism ; Oxygen - metabolism ; Respiratory Burst - drug effects</subject><ispartof>European journal of pharmacology, 1998-11, Vol.361 (2-3), p.293-298</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2170-897b4bdb041c9a8cfaf97f79f7f6a14bd9a723b4af365d2545824ffe52886a623</citedby><cites>FETCH-LOGICAL-c2170-897b4bdb041c9a8cfaf97f79f7f6a14bd9a723b4af365d2545824ffe52886a623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9865520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallois, A</creatorcontrib><creatorcontrib>Bueb, J L</creatorcontrib><creatorcontrib>Tschirhart, E</creatorcontrib><title>Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in the absence of extracellular Ca2+ resulted in a major reduction of [Ca2+]i rise and O2- production. A purported inhibitor of store-operated Ca2+ entry, SK&F 96365 (1-(beta-(3-(4-methoxy-phenyl)propoxyl)-4-methoxy-phenetyl)- 1H-imidazole hydrochloride), inhibited extracellular Ca2+ -dependent [Ca2+]i rise by 30% but did not alter O2- production. In conclusion, SK&F 96365 did not modify extracellular Ca2+ -dependent O2- production, despite a significant but limited reduction in fMLP-activated membrane Ca2+ fluxes which can be ascribed to store-operated Ca2+ entry. Furthermore, Ca2+ influx is necessary for a full induction and maintenance of the biological response.</description><subject>Calcium - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Imidazoles - pharmacology</subject><subject>Manganese - metabolism</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Respiratory Burst - drug effects</subject><issn>0014-2999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kFFLwzAUhfOgzDn9CYM8DUWiN2mTJo8yNicO9jB9DmmaYLVra9KC_ntbN3y6cO855x4-hOYU7ilQ8RABaEqYUupGyVuAjEkiztD0f32BLmP8AACuGJ-giZKCcwZTZFfeO9vhxuP9y2KNlUgEx02N3XcXjHVV1Vcm4KVhd5gUrnV14eoO7xjBbWiK3nblIC5rXLu-C037XlakKj8d3myJADwGxCt07k0V3fVpztDbevW63JDt7ul5-bglltEMiFRZnuZFDim1ykjrjVeZz5TPvDB0uCiTsSRPjR8qFoynXLJ0aM-ZlMIIlszQ4pg7NPvqXez0oYxjA1O7po9aKApcCjkI-VFoQxNjcF63oTyY8KMp6BGo3o_k9EhOK6n_gGox-OanB31-cMW_60Qz-QVyJXC9</recordid><startdate>19981120</startdate><enddate>19981120</enddate><creator>Gallois, A</creator><creator>Bueb, J L</creator><creator>Tschirhart, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981120</creationdate><title>Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells</title><author>Gallois, A ; Bueb, J L ; Tschirhart, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2170-897b4bdb041c9a8cfaf97f79f7f6a14bd9a723b4af365d2545824ffe52886a623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Calcium - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Manganese - metabolism</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Respiratory Burst - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallois, A</creatorcontrib><creatorcontrib>Bueb, J L</creatorcontrib><creatorcontrib>Tschirhart, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallois, A</au><au>Bueb, J L</au><au>Tschirhart, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1998-11-20</date><risdate>1998</risdate><volume>361</volume><issue>2-3</issue><spage>293</spage><epage>298</epage><pages>293-298</pages><issn>0014-2999</issn><abstract>Store-operated Ca2+ entry is referred to a capacitative current activated by Ca2+ -stores depletion in various non-excitable cells. Neutrophil-like HL-60 cells responded to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLP) by an early O2- production preceded by a [Ca2+]i rise. Cell stimulation in the absence of extracellular Ca2+ resulted in a major reduction of [Ca2+]i rise and O2- production. A purported inhibitor of store-operated Ca2+ entry, SK&F 96365 (1-(beta-(3-(4-methoxy-phenyl)propoxyl)-4-methoxy-phenetyl)- 1H-imidazole hydrochloride), inhibited extracellular Ca2+ -dependent [Ca2+]i rise by 30% but did not alter O2- production. In conclusion, SK&F 96365 did not modify extracellular Ca2+ -dependent O2- production, despite a significant but limited reduction in fMLP-activated membrane Ca2+ fluxes which can be ascribed to store-operated Ca2+ entry. Furthermore, Ca2+ influx is necessary for a full induction and maintenance of the biological response.</abstract><cop>Netherlands</cop><pmid>9865520</pmid><doi>10.1016/s0014-2999(98)00728-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1998-11, Vol.361 (2-3), p.293-298 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Calcium - metabolism Calcium Channel Blockers - pharmacology HL-60 Cells Humans Imidazoles - pharmacology Manganese - metabolism N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - metabolism Oxygen - metabolism Respiratory Burst - drug effects |
| title | Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells |
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