Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

Sorting of signal-transducing cell surface receptors within multivesicular bodies (MVBs) is required for their rapid down-regulation and degradation within lysosomes. Yeast mutants defective in late stages of transport to the vacuole/lysosome accumulate MVBs. We demonstrate that the membrane glycopr...

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Veröffentlicht in:	Cell 1998-12, Vol.95 (6), p.847-858
Hauptverfasser:	Odorizzi, Greg, Babst, Markus, Emr, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Biological Transport Carboxypeptidases - metabolism Endosomal Sorting Complexes Required for Transport Endosomes Fungal Proteins - genetics Fungal Proteins - physiology Green Fluorescent Proteins Luminescent Proteins - metabolism Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Proteins Vacuoles
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