Application of an HIV gp41-Derived Peptide for Enhanced Intracellular Trafficking of Synthetic Gene and siRNA Delivery Vehicles

Endosomal release is an efficiency-limiting step for many nonviral gene delivery vehicles. In this work, nonviral gene delivery vehicles were modified with a membrane-lytic peptide taken from the endodomain of HIV gp41. Peptide was covalently linked to polyethylenimine (PEI) and the peptide-modified...

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Veröffentlicht in:	Bioconjugate chemistry 2008-04, Vol.19 (4), p.920-927
Hauptverfasser:	Kwon, Ester J, Bergen, Jamie M, Pun, Suzie H
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - metabolism Cells Chloroquine - metabolism DNA - metabolism Endosomes - metabolism Gene expression Gene Transfer Techniques Genes, Synthetic HeLa Cells HIV HIV Envelope Protein gp41 - chemistry Human immunodeficiency virus Humans Intracellular Space - metabolism Membranes Microscopy, Confocal Peptides Peptides - chemistry Peptides - metabolism Polyethyleneimine - metabolism Polymers Protein Structure, Tertiary Ribonucleic acid RNA RNA, Small Interfering - metabolism Transfection Transgenes
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