Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis
Objective: To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients. Methods: Interleukin (IL)-1 α , 1 β , 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 h...
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| Veröffentlicht in: | Infection 2008-04, Vol.36 (2), p.147-152 |
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| creator | Anton, G. Rid, J. Mylonas, I. Friese, K. Weissenbacher, E.-R. |
| description | Objective:
To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients.
Methods:
Interleukin (IL)-1
α
, 1
β
, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women.
Results:
Levels of IL-1
β
were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1
α
in BV patients, but these data were not statistically significant.
Conclusion:
We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections. |
| doi_str_mv | 10.1007/s15010-007-7152-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69102833</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20015550</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-68c48c5fd3e45b48d26ac82f63c0d4799ed3879bbcfa2be9632b4b5fa00a6853</originalsourceid><addsrcrecordid>eNqFkU9LxDAQxYMouq5-AC9SPHiLTpImbY66_llhQdBF8FTSNNFK26xJK_jtTdkVQRBP8wZ-84aZh9ARgTMCkJ0HwoEAjhJnhFNMt9CEpExikBnbRhNgADgnVOyh_RDeAIDLNNtFeyRnDDiICXq-_qgr02mTOJuoZDkn-PG1tv3YLpxWTfKkXuou1rvONqptVe_8Z_Jgwsp1wSRXg6-7l-RS6d74-ht3oQ4HaMeqJpjDTZ2i5c31cjbHi_vbu9nFAusUoMci12muua2YSXmZ5hUVSufUCqahSjMpTcXyTJaltoqWRgpGy7TkVgEokXM2Radr25V374MJfdHWQZumUZ1xQyiEJEDjuf-CFIBwziGCJ7_ANzf4-ILIEC4iRGWEyBrS3oXgjS1Wvm6V_ywIFGM4xTqcYpRjOAWNM8cb46FsTfUzsUkjAnQNhNX4VeN_Nv_t-gXiqJhV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215615529</pqid></control><display><type>article</type><title>Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Anton, G. ; Rid, J. ; Mylonas, I. ; Friese, K. ; Weissenbacher, E.-R.</creator><creatorcontrib>Anton, G. ; Rid, J. ; Mylonas, I. ; Friese, K. ; Weissenbacher, E.-R.</creatorcontrib><description>Objective:
To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients.
Methods:
Interleukin (IL)-1
α
, 1
β
, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women.
Results:
Levels of IL-1
β
were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1
α
in BV patients, but these data were not statistically significant.
Conclusion:
We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>EISSN: 1439-0972</identifier><identifier>DOI: 10.1007/s15010-007-7152-2</identifier><identifier>PMID: 18330506</identifier><language>eng</language><publisher>Munich: Urban & Vogel</publisher><subject>Adolescent ; Adult ; Bacteria ; Chi-Square Distribution ; Clinical and Epidemiological Study ; Enzyme-Linked Immunosorbent Assay ; Family Medicine ; Female ; General Practice ; Humans ; Hydrogen-Ion Concentration ; Infectious Diseases ; Interleukins - analysis ; Internal Medicine ; Lactobacillus - isolation & purification ; Medicine ; Medicine & Public Health ; Middle Aged ; Statistics, Nonparametric ; Th1 Cells - immunology ; Vagina - immunology ; Vagina - microbiology ; Vagina - pathology ; Vaginosis, Bacterial - immunology ; Vaginosis, Bacterial - pathology</subject><ispartof>Infection, 2008-04, Vol.36 (2), p.147-152</ispartof><rights>Urban & Vogel München 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-68c48c5fd3e45b48d26ac82f63c0d4799ed3879bbcfa2be9632b4b5fa00a6853</citedby><cites>FETCH-LOGICAL-c400t-68c48c5fd3e45b48d26ac82f63c0d4799ed3879bbcfa2be9632b4b5fa00a6853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-007-7152-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-007-7152-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18330506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anton, G.</creatorcontrib><creatorcontrib>Rid, J.</creatorcontrib><creatorcontrib>Mylonas, I.</creatorcontrib><creatorcontrib>Friese, K.</creatorcontrib><creatorcontrib>Weissenbacher, E.-R.</creatorcontrib><title>Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Objective:
To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients.
Methods:
Interleukin (IL)-1
α
, 1
β
, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women.
Results:
Levels of IL-1
β
were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1
α
in BV patients, but these data were not statistically significant.
Conclusion:
We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacteria</subject><subject>Chi-Square Distribution</subject><subject>Clinical and Epidemiological Study</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Family Medicine</subject><subject>Female</subject><subject>General Practice</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infectious Diseases</subject><subject>Interleukins - analysis</subject><subject>Internal Medicine</subject><subject>Lactobacillus - isolation & purification</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Statistics, Nonparametric</subject><subject>Th1 Cells - immunology</subject><subject>Vagina - immunology</subject><subject>Vagina - microbiology</subject><subject>Vagina - pathology</subject><subject>Vaginosis, Bacterial - immunology</subject><subject>Vaginosis, Bacterial - pathology</subject><issn>0300-8126</issn><issn>1439-0973</issn><issn>1439-0972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU9LxDAQxYMouq5-AC9SPHiLTpImbY66_llhQdBF8FTSNNFK26xJK_jtTdkVQRBP8wZ-84aZh9ARgTMCkJ0HwoEAjhJnhFNMt9CEpExikBnbRhNgADgnVOyh_RDeAIDLNNtFeyRnDDiICXq-_qgr02mTOJuoZDkn-PG1tv3YLpxWTfKkXuou1rvONqptVe_8Z_Jgwsp1wSRXg6-7l-RS6d74-ht3oQ4HaMeqJpjDTZ2i5c31cjbHi_vbu9nFAusUoMci12muua2YSXmZ5hUVSufUCqahSjMpTcXyTJaltoqWRgpGy7TkVgEokXM2Radr25V374MJfdHWQZumUZ1xQyiEJEDjuf-CFIBwziGCJ7_ANzf4-ILIEC4iRGWEyBrS3oXgjS1Wvm6V_ywIFGM4xTqcYpRjOAWNM8cb46FsTfUzsUkjAnQNhNX4VeN_Nv_t-gXiqJhV</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Anton, G.</creator><creator>Rid, J.</creator><creator>Mylonas, I.</creator><creator>Friese, K.</creator><creator>Weissenbacher, E.-R.</creator><general>Urban & Vogel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7T7</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis</title><author>Anton, G. ; Rid, J. ; Mylonas, I. ; Friese, K. ; Weissenbacher, E.-R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-68c48c5fd3e45b48d26ac82f63c0d4799ed3879bbcfa2be9632b4b5fa00a6853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bacteria</topic><topic>Chi-Square Distribution</topic><topic>Clinical and Epidemiological Study</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Family Medicine</topic><topic>Female</topic><topic>General Practice</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infectious Diseases</topic><topic>Interleukins - analysis</topic><topic>Internal Medicine</topic><topic>Lactobacillus - isolation & purification</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Statistics, Nonparametric</topic><topic>Th1 Cells - immunology</topic><topic>Vagina - immunology</topic><topic>Vagina - microbiology</topic><topic>Vagina - pathology</topic><topic>Vaginosis, Bacterial - immunology</topic><topic>Vaginosis, Bacterial - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anton, G.</creatorcontrib><creatorcontrib>Rid, J.</creatorcontrib><creatorcontrib>Mylonas, I.</creatorcontrib><creatorcontrib>Friese, K.</creatorcontrib><creatorcontrib>Weissenbacher, E.-R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anton, G.</au><au>Rid, J.</au><au>Mylonas, I.</au><au>Friese, K.</au><au>Weissenbacher, E.-R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>36</volume><issue>2</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><eissn>1439-0972</eissn><abstract>Objective:
To determine the levels of pro-inflammatory and anti-inflammatory cytokines in the vagina of healthy women and in bacterial vaginosis (BV) patients.
Methods:
Interleukin (IL)-1
α
, 1
β
, 5 and 10 were analyzed by ELISA in vaginal wash fluids from 50 non-pregnant patients with BV and 112 healthy women.
Results:
Levels of IL-1
β
were higher and those of IL-10 lower in BV-patients than in healthy women. There was a tendency towards higher levels of IL-1
α
in BV patients, but these data were not statistically significant.
Conclusion:
We found evidence for a shift towards a TH1-dominated vaginal cytokine profile in the pathogenesis of BV. Levels of a TH1-cytokine were elevated and those of a TH2-cytokine lowered in BV-patients as compared to healthy controls. This points to a vaginal TH1-response during BV and to the importance of cell-mediated immunity in local vaginal infections.</abstract><cop>Munich</cop><pub>Urban & Vogel</pub><pmid>18330506</pmid><doi>10.1007/s15010-007-7152-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 2008-04, Vol.36 (2), p.147-152 |
| issn | 0300-8126 1439-0973 1439-0972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69102833 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Adult Bacteria Chi-Square Distribution Clinical and Epidemiological Study Enzyme-Linked Immunosorbent Assay Family Medicine Female General Practice Humans Hydrogen-Ion Concentration Infectious Diseases Interleukins - analysis Internal Medicine Lactobacillus - isolation & purification Medicine Medicine & Public Health Middle Aged Statistics, Nonparametric Th1 Cells - immunology Vagina - immunology Vagina - microbiology Vagina - pathology Vaginosis, Bacterial - immunology Vaginosis, Bacterial - pathology |
| title | Evidence of a TH1-Shift of Local Vaginal Inflammatory Response During Bacterial Vaginosis |
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