Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy
Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ibuproxam with some currently employed pharmaceutical excipients. The influence of processing effects (simple blending, cogrinding or kneading) on drug stability was also evaluated. On the ba...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1998-10, Vol.18 (1-2), p.151-163 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Mura, P. Faucci, M.T. Manderioli, A. Bramanti, G. Ceccarelli, L. |
| description | Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ibuproxam with some currently employed pharmaceutical excipients. The influence of processing effects (simple blending, cogrinding or kneading) on drug stability was also evaluated. On the basis of DSC results, ibuproxam was found to be compatible with corn starch, avicel and sodium carboxymethylcellulose. Some drug-excipient interaction was observed with polyethyleneglycol 4000, palmitic acid, stearic acid, Ca and Mg stearate. Actual solid-phase interactions of the drug with polyvinylpolypyrrolidone and polyvinylpirrolidone K30 were induced by mechanical treatments. Hot-stage microscopy (HSM) and scanning electron microscopy (SEM) were of help in interpreting the DSC results and excluding in all cases relevant pharmaceutical incompatibilities. |
| doi_str_mv | 10.1016/S0731-7085(98)00171-X |
| format | Article |
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The influence of processing effects (simple blending, cogrinding or kneading) on drug stability was also evaluated. On the basis of DSC results, ibuproxam was found to be compatible with corn starch, avicel and sodium carboxymethylcellulose. Some drug-excipient interaction was observed with polyethyleneglycol 4000, palmitic acid, stearic acid, Ca and Mg stearate. Actual solid-phase interactions of the drug with polyvinylpolypyrrolidone and polyvinylpirrolidone K30 were induced by mechanical treatments. Hot-stage microscopy (HSM) and scanning electron microscopy (SEM) were of help in interpreting the DSC results and excluding in all cases relevant pharmaceutical incompatibilities.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(98)00171-X</identifier><identifier>PMID: 9863953</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Benzeneacetamides ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Calorimetry, Differential Scanning ; Compatibility ; Differential scanning calorimetry ; Drug Incompatibility ; Drug Stability ; Excipients ; Excipients - chemistry ; Hot Temperature - adverse effects ; Hot-stage microscopy ; Hydroxamic Acids - chemistry ; Ibuproxam ; Medical sciences ; Microscopy ; Microscopy, Electron, Scanning ; Pharmacology. Drug treatments ; Scanning electron microscopy</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 1998-10, Vol.18 (1-2), p.151-163</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-a59391c8565d6fe774b5a3941d4fa12d2149ee6acf280bb6e3b7031e0aee94c43</citedby><cites>FETCH-LOGICAL-c455t-a59391c8565d6fe774b5a3941d4fa12d2149ee6acf280bb6e3b7031e0aee94c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0731-7085(98)00171-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,23911,23912,25121,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1654326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9863953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mura, P.</creatorcontrib><creatorcontrib>Faucci, M.T.</creatorcontrib><creatorcontrib>Manderioli, A.</creatorcontrib><creatorcontrib>Bramanti, G.</creatorcontrib><creatorcontrib>Ceccarelli, L.</creatorcontrib><title>Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ibuproxam with some currently employed pharmaceutical excipients. The influence of processing effects (simple blending, cogrinding or kneading) on drug stability was also evaluated. On the basis of DSC results, ibuproxam was found to be compatible with corn starch, avicel and sodium carboxymethylcellulose. Some drug-excipient interaction was observed with polyethyleneglycol 4000, palmitic acid, stearic acid, Ca and Mg stearate. Actual solid-phase interactions of the drug with polyvinylpolypyrrolidone and polyvinylpirrolidone K30 were induced by mechanical treatments. Hot-stage microscopy (HSM) and scanning electron microscopy (SEM) were of help in interpreting the DSC results and excluding in all cases relevant pharmaceutical incompatibilities.</description><subject>Benzeneacetamides</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Calorimetry, Differential Scanning</subject><subject>Compatibility</subject><subject>Differential scanning calorimetry</subject><subject>Drug Incompatibility</subject><subject>Drug Stability</subject><subject>Excipients</subject><subject>Excipients - chemistry</subject><subject>Hot Temperature - adverse effects</subject><subject>Hot-stage microscopy</subject><subject>Hydroxamic Acids - chemistry</subject><subject>Ibuproxam</subject><subject>Medical sciences</subject><subject>Microscopy</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmacology. Drug treatments</subject><subject>Scanning electron microscopy</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuKFTEQhoMo43H0EQayEFGwNelcurMSOXiDARcqnF1Ip6tnIt1Jm6R1-nV8UnMuHN25ClR99afq_xG6ouQVJVS-_kIaRquGtOK5al8QQhta7e6hDW0bVtWS7-6jzRl5iB6l9J0QIqjiF-hCtZIpwTbo9zZMs8muc6PLK0556VfcQf4F4LHrljmGOzNh43s835o4GQtLdtaMGO6smx34nPCSnL_BvRsGiKXgSjdZ4_2-WtAQ3QQ5ri_xbchVyuYG8ORsDMmGeT1on3EYweYY_D_AY_RgMGOCJ6f3En17_-7r9mN1_fnDp-3b68pyIXJlhGKK2lZI0csBmoZ3wjDFac8HQ-u-plwBSGOHuiVdJ4F1DWEUiAFQ3HJ2iZ4ddcvNPxZIWU8uWRhH4yEsSUtFSc0lKaA4gvsNU4RBz-VCE1dNid5now_Z6L3xWrX6kI3elbmr0wdLN0F_njqFUfpPT31T_BiHaLx16a-4FJzVsmBvjhgUM346iDrZkoOF3sVinu6D-88ifwB40rFs</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Mura, P.</creator><creator>Faucci, M.T.</creator><creator>Manderioli, A.</creator><creator>Bramanti, G.</creator><creator>Ceccarelli, L.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy</title><author>Mura, P. ; Faucci, M.T. ; Manderioli, A. ; Bramanti, G. ; Ceccarelli, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-a59391c8565d6fe774b5a3941d4fa12d2149ee6acf280bb6e3b7031e0aee94c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Benzeneacetamides</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Calorimetry, Differential Scanning</topic><topic>Compatibility</topic><topic>Differential scanning calorimetry</topic><topic>Drug Incompatibility</topic><topic>Drug Stability</topic><topic>Excipients</topic><topic>Excipients - chemistry</topic><topic>Hot Temperature - adverse effects</topic><topic>Hot-stage microscopy</topic><topic>Hydroxamic Acids - chemistry</topic><topic>Ibuproxam</topic><topic>Medical sciences</topic><topic>Microscopy</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pharmacology. Drug treatments</topic><topic>Scanning electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mura, P.</creatorcontrib><creatorcontrib>Faucci, M.T.</creatorcontrib><creatorcontrib>Manderioli, A.</creatorcontrib><creatorcontrib>Bramanti, G.</creatorcontrib><creatorcontrib>Ceccarelli, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mura, P.</au><au>Faucci, M.T.</au><au>Manderioli, A.</au><au>Bramanti, G.</au><au>Ceccarelli, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>18</volume><issue>1-2</issue><spage>151</spage><epage>163</epage><pages>151-163</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Differential scanning calorimetry (DSC) was used as a screening technique for assessing the compatibility of ibuproxam with some currently employed pharmaceutical excipients. The influence of processing effects (simple blending, cogrinding or kneading) on drug stability was also evaluated. On the basis of DSC results, ibuproxam was found to be compatible with corn starch, avicel and sodium carboxymethylcellulose. Some drug-excipient interaction was observed with polyethyleneglycol 4000, palmitic acid, stearic acid, Ca and Mg stearate. Actual solid-phase interactions of the drug with polyvinylpolypyrrolidone and polyvinylpirrolidone K30 were induced by mechanical treatments. Hot-stage microscopy (HSM) and scanning electron microscopy (SEM) were of help in interpreting the DSC results and excluding in all cases relevant pharmaceutical incompatibilities.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9863953</pmid><doi>10.1016/S0731-7085(98)00171-X</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical and biomedical analysis, 1998-10, Vol.18 (1-2), p.151-163 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Benzeneacetamides Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calorimetry, Differential Scanning Compatibility Differential scanning calorimetry Drug Incompatibility Drug Stability Excipients Excipients - chemistry Hot Temperature - adverse effects Hot-stage microscopy Hydroxamic Acids - chemistry Ibuproxam Medical sciences Microscopy Microscopy, Electron, Scanning Pharmacology. Drug treatments Scanning electron microscopy |
| title | Compatibility study between ibuproxam and pharmaceutical excipients using differential scanning calorimetry, hot-stage microscopy and scanning electron microscopy |
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