The Unusually Slow Unfolding Rate Causes the High Stability of Pyrrolidone Carboxyl Peptidase from a Hyperthermophile, Pyrococcus furiosus:  Equilibrium and Kinetic Studies of Guanidine Hydrochloride-Induced Unfolding and Refolding

To elucidate the energetic features of the anomalously high-level stabilization of a hyperthermophile pyrrolidone carboxyl peptidase (PfPCP) from a hyperthermophilic archaeon, Pyrococcus furiosus, equilibrium and kinetic studies of the guanidine hydrochloride (GuHCl)-induced unfolding and refolding...

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Veröffentlicht in:	Biochemistry (Easton) 1998-12, Vol.37 (50), p.17537-17544
Hauptverfasser:	Ogasahara, Kyoko, Nakamura, Mamoru, Nakura, Satomi, Tsunasawa, Susumu, Kato, Ikunoshin, Yoshimoto, Tadashi, Yutani, Katsuhide
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus amyloliquefaciens Circular Dichroism Dose-Response Relationship, Drug Enzyme Stability - drug effects Guanidine - pharmacology Hot Temperature Kinetics Protein Folding Pyrococcus furiosus Pyrococcus furiosus - enzymology Pyroglutamyl-Peptidase I - chemistry Pyroglutamyl-Peptidase I - metabolism Thermodynamics
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