Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig
Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rhGDF‐5) enhances bone formation in sinus floor augmentations in miniature pigs. Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented wi...
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| Veröffentlicht in: | Clinical oral implants research 2008-05, Vol.19 (5), p.522-529 |
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| creator | Gruber, Rudolf M. Ludwig, Arwed Merten, Hans-Albert Achilles, Mirjam Poehling, Sylke Schliephake, Henning |
| description | Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rhGDF‐5) enhances bone formation in sinus floor augmentations in miniature pigs.
Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with β‐tricalcium phosphate (β‐TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF‐5 (400 μg rhGDF‐5/g β‐TCP; 800 μg rhGDF‐5/g β‐TCP) delivered on β‐TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non‐decalcified histological specimens was performed.
Results: The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 μg/g β‐TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05).
The bone‐to‐implant contact rates were also significantly enhanced after 4 weeks between test sites (400 μg: 41.9%; 800 μg: 40.6%) and control sites (400 μg: 7.8%; 800 μg: 16.4%) (400 μg: P=0.024; 800 μg: P=0.048).
Conclusion: It is concluded that rhGDF‐5 delivered on β‐TCP significantly enhanced early bone formation compared with β‐TCP alone in sinus lift procedures in miniature pigs. |
| doi_str_mv | 10.1111/j.1600-0501.2007.01494.x |
| format | Article |
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Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with β‐tricalcium phosphate (β‐TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF‐5 (400 μg rhGDF‐5/g β‐TCP; 800 μg rhGDF‐5/g β‐TCP) delivered on β‐TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non‐decalcified histological specimens was performed.
Results: The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 μg/g β‐TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05).
The bone‐to‐implant contact rates were also significantly enhanced after 4 weeks between test sites (400 μg: 41.9%; 800 μg: 40.6%) and control sites (400 μg: 7.8%; 800 μg: 16.4%) (400 μg: P=0.024; 800 μg: P=0.048).
Conclusion: It is concluded that rhGDF‐5 delivered on β‐TCP significantly enhanced early bone formation compared with β‐TCP alone in sinus lift procedures in miniature pigs.</description><identifier>ISSN: 0905-7161</identifier><identifier>EISSN: 1600-0501</identifier><identifier>DOI: 10.1111/j.1600-0501.2007.01494.x</identifier><identifier>PMID: 18371105</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; BMP ; Bone Density - drug effects ; bone formation ; Bone Morphogenetic Proteins - pharmacology ; Bone Regeneration - drug effects ; Calcium Phosphates - pharmacology ; Dental Implantation, Endosseous ; Dentistry ; Female ; Growth Differentiation Factor 5 ; Maxillary Sinus - surgery ; Microscopy, Fluorescence ; Oral Surgical Procedures, Preprosthetic - methods ; osteoinduction ; Recombinant Proteins - pharmacology ; sinus augmentation ; Swine ; Swine, Miniature</subject><ispartof>Clinical oral implants research, 2008-05, Vol.19 (5), p.522-529</ispartof><rights>2008 The Authors</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4364-c3463cf6c206c9cfaa58f742426df595bcde48e0ca6977f5779f1e259e4653f83</citedby><cites>FETCH-LOGICAL-c4364-c3463cf6c206c9cfaa58f742426df595bcde48e0ca6977f5779f1e259e4653f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0501.2007.01494.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0501.2007.01494.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18371105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gruber, Rudolf M.</creatorcontrib><creatorcontrib>Ludwig, Arwed</creatorcontrib><creatorcontrib>Merten, Hans-Albert</creatorcontrib><creatorcontrib>Achilles, Mirjam</creatorcontrib><creatorcontrib>Poehling, Sylke</creatorcontrib><creatorcontrib>Schliephake, Henning</creatorcontrib><title>Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig</title><title>Clinical oral implants research</title><addtitle>Clin Oral Implants Res</addtitle><description>Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rhGDF‐5) enhances bone formation in sinus floor augmentations in miniature pigs.
Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with β‐tricalcium phosphate (β‐TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF‐5 (400 μg rhGDF‐5/g β‐TCP; 800 μg rhGDF‐5/g β‐TCP) delivered on β‐TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non‐decalcified histological specimens was performed.
Results: The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 μg/g β‐TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05).
The bone‐to‐implant contact rates were also significantly enhanced after 4 weeks between test sites (400 μg: 41.9%; 800 μg: 40.6%) and control sites (400 μg: 7.8%; 800 μg: 16.4%) (400 μg: P=0.024; 800 μg: P=0.048).
Conclusion: It is concluded that rhGDF‐5 delivered on β‐TCP significantly enhanced early bone formation compared with β‐TCP alone in sinus lift procedures in miniature pigs.</description><subject>Animals</subject><subject>BMP</subject><subject>Bone Density - drug effects</subject><subject>bone formation</subject><subject>Bone Morphogenetic Proteins - pharmacology</subject><subject>Bone Regeneration - drug effects</subject><subject>Calcium Phosphates - pharmacology</subject><subject>Dental Implantation, Endosseous</subject><subject>Dentistry</subject><subject>Female</subject><subject>Growth Differentiation Factor 5</subject><subject>Maxillary Sinus - surgery</subject><subject>Microscopy, Fluorescence</subject><subject>Oral Surgical Procedures, Preprosthetic - methods</subject><subject>osteoinduction</subject><subject>Recombinant Proteins - pharmacology</subject><subject>sinus augmentation</subject><subject>Swine</subject><subject>Swine, Miniature</subject><issn>0905-7161</issn><issn>1600-0501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-P1CAchhujccfVr2A4GT20QlugmHjYjM5oMlmTXf8cCUOhZWxhBJqZ-Uh-S9vpZD0qFwi_93kheZIEIJihcb3dZYhAmEIMUZZDSDOISlZmx0fJ4mHwOFlABnFKEUFXybMQdhBCwir2NLlCVUERgniR_L43dghAd855IIamVzaKaJwFBxNb4JV0_dZYYSNoh15Y0Hh3GAfC1qA2Wis_AmYmtJDR-RSD175df1il-M07IEBrQnSda4wU3Rk7X_TO71vXq-iNBCEO9QkYC2KrwNqpGI1tlAW9sWP14BXYm-Z58kSLLqgXl_06-bb6-HX5Kd18WX9e3mxSWRakTGVRkkJqInNIJJNaCFxpWuZlTmqNGd7KWpWVglIQRqnGlDKNVI6ZKgkudFVcJ6_m3r13vwYVIu9NkKrrhFVuCJwwBHOE8n8Gxw8wVFE6Bqs5KL0LwSvN9970wp84gnzyyXd80sYnbXzyyc8--XFEX17eGLa9qv-CF4Fj4P0cOJhOnf67mC83d9Np5NOZH6Wo4wMv_E9OaEEx_3G75vf591u8IgW_K_4AV1bAuw</recordid><startdate>200805</startdate><enddate>200805</enddate><creator>Gruber, Rudolf M.</creator><creator>Ludwig, Arwed</creator><creator>Merten, Hans-Albert</creator><creator>Achilles, Mirjam</creator><creator>Poehling, Sylke</creator><creator>Schliephake, Henning</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200805</creationdate><title>Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig</title><author>Gruber, Rudolf M. ; Ludwig, Arwed ; Merten, Hans-Albert ; Achilles, Mirjam ; Poehling, Sylke ; Schliephake, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-c3463cf6c206c9cfaa58f742426df595bcde48e0ca6977f5779f1e259e4653f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>BMP</topic><topic>Bone Density - drug effects</topic><topic>bone formation</topic><topic>Bone Morphogenetic Proteins - pharmacology</topic><topic>Bone Regeneration - drug effects</topic><topic>Calcium Phosphates - pharmacology</topic><topic>Dental Implantation, Endosseous</topic><topic>Dentistry</topic><topic>Female</topic><topic>Growth Differentiation Factor 5</topic><topic>Maxillary Sinus - surgery</topic><topic>Microscopy, Fluorescence</topic><topic>Oral Surgical Procedures, Preprosthetic - methods</topic><topic>osteoinduction</topic><topic>Recombinant Proteins - pharmacology</topic><topic>sinus augmentation</topic><topic>Swine</topic><topic>Swine, Miniature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gruber, Rudolf M.</creatorcontrib><creatorcontrib>Ludwig, Arwed</creatorcontrib><creatorcontrib>Merten, Hans-Albert</creatorcontrib><creatorcontrib>Achilles, Mirjam</creatorcontrib><creatorcontrib>Poehling, Sylke</creatorcontrib><creatorcontrib>Schliephake, Henning</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral implants research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gruber, Rudolf M.</au><au>Ludwig, Arwed</au><au>Merten, Hans-Albert</au><au>Achilles, Mirjam</au><au>Poehling, Sylke</au><au>Schliephake, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig</atitle><jtitle>Clinical oral implants research</jtitle><addtitle>Clin Oral Implants Res</addtitle><date>2008-05</date><risdate>2008</risdate><volume>19</volume><issue>5</issue><spage>522</spage><epage>529</epage><pages>522-529</pages><issn>0905-7161</issn><eissn>1600-0501</eissn><abstract>Aim: The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor‐5 (rhGDF‐5) enhances bone formation in sinus floor augmentations in miniature pigs.
Material and methods: The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with β‐tricalcium phosphate (β‐TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF‐5 (400 μg rhGDF‐5/g β‐TCP; 800 μg rhGDF‐5/g β‐TCP) delivered on β‐TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non‐decalcified histological specimens was performed.
Results: The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 μg/g β‐TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05).
The bone‐to‐implant contact rates were also significantly enhanced after 4 weeks between test sites (400 μg: 41.9%; 800 μg: 40.6%) and control sites (400 μg: 7.8%; 800 μg: 16.4%) (400 μg: P=0.024; 800 μg: P=0.048).
Conclusion: It is concluded that rhGDF‐5 delivered on β‐TCP significantly enhanced early bone formation compared with β‐TCP alone in sinus lift procedures in miniature pigs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18371105</pmid><doi>10.1111/j.1600-0501.2007.01494.x</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals BMP Bone Density - drug effects bone formation Bone Morphogenetic Proteins - pharmacology Bone Regeneration - drug effects Calcium Phosphates - pharmacology Dental Implantation, Endosseous Dentistry Female Growth Differentiation Factor 5 Maxillary Sinus - surgery Microscopy, Fluorescence Oral Surgical Procedures, Preprosthetic - methods osteoinduction Recombinant Proteins - pharmacology sinus augmentation Swine Swine, Miniature |
| title | Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig |
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