Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat

We have recently shown that endomorphin1, an endogenous ligand for the μ-opioid receptor, and nociceptin (Orphanin FQ; OFQ), an endogenous ligand for the ORL 1 receptor, have substantial vasodilator activity in the hindquarters vascular bed of the rat. In the present study, the role of nitric oxide,...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1998, Vol.19 (9), p.1595-1602
Hauptverfasser:	Champion, H.C, Bivalacqua, T.J, Friedman, D.E, Zadina, J.E, Kastin, A.J, Kadowitz, P.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - pharmacology Animals Blood Vessels - drug effects Endomorphin 1 Endorphins - pharmacology Endothelium, Vascular - metabolism Endothelium-dependent vasodilator Enkephalin, Ala-MePhe-Gly Enkephalins - pharmacology Hindquarters vascular bed Meclofenamic Acid - pharmacology Morpholines - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - metabolism Nitric oxide-dependent vasodilator Nociceptin Oligopeptides - pharmacology Opioid Peptides - pharmacology Potassium Channels - metabolism Rats Rats, Sprague-Dawley Receptors, Opioid - agonists Regional Blood Flow - drug effects Vasodilation - drug effects Vasodilator Agents - pharmacology
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