Experimental design for a pharmaceutical formulation: optimisation and robustness
In pharmaceutical industries, the formulator is usually faced with the optimisation of the excipient mixture composition aimed to prepare a product with the required characteristics. Experimental research methodology represents an efficient approach for solving such optimisation problems. Planning m...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 1998-10, Vol.18 (1-2), p.57-65 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Campisi, B. Chicco, D. Vojnovic, D. Phan-Tan-Luu, R. |
| description | In pharmaceutical industries, the formulator is usually faced with the optimisation of the excipient mixture composition aimed to prepare a product with the required characteristics. Experimental research methodology represents an efficient approach for solving such optimisation problems. Planning mixture experiments using specific designs allows to analyse the blending properties of each mixture component and estimate an empirical model approximating the response of interest as a function of excipient proportions. In this study the evolution of theophylline solubility in a four-component system with constraints was analysed using two mixture design approaches: a classical mixture component proportion approach and a mathematically independent variable approach. An optimal region characterised by high solubility values was found and further explored in order to verify the insensitivity of theophylline solubility to slight variations of the excipient mixture composition. |
| doi_str_mv | 10.1016/S0731-7085(98)00175-7 |
| format | Article |
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Experimental research methodology represents an efficient approach for solving such optimisation problems. Planning mixture experiments using specific designs allows to analyse the blending properties of each mixture component and estimate an empirical model approximating the response of interest as a function of excipient proportions. In this study the evolution of theophylline solubility in a four-component system with constraints was analysed using two mixture design approaches: a classical mixture component proportion approach and a mathematically independent variable approach. 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Experimental research methodology represents an efficient approach for solving such optimisation problems. Planning mixture experiments using specific designs allows to analyse the blending properties of each mixture component and estimate an empirical model approximating the response of interest as a function of excipient proportions. In this study the evolution of theophylline solubility in a four-component system with constraints was analysed using two mixture design approaches: a classical mixture component proportion approach and a mathematically independent variable approach. An optimal region characterised by high solubility values was found and further explored in order to verify the insensitivity of theophylline solubility to slight variations of the excipient mixture composition.</description><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Component proportion approach</subject><subject>Cosolvent mixture optimisation</subject><subject>Drug Compounding - methods</subject><subject>Drug Compounding - standards</subject><subject>Experimental mixture design</subject><subject>General pharmacology</subject><subject>Mathematically independent variable approach</subject><subject>Medical sciences</subject><subject>Models, Theoretical</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Reproducibility of Results</subject><subject>Research Design</subject><subject>Sensitivity and Specificity</subject><subject>Solubility</subject><subject>Theophylline - chemistry</subject><subject>Theophylline solubility</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfoTALEV2M5jIzSdyIlHqBgogK7kKaOaORuZnMiL69aTvUpauQ_N85OedDaErwOcEku3jCnJGYY5GeSnGGMeFpzHfQmAjOYpolr7tovEX20YH3HxjjlMhkhEZSZEwmbIwe598tOFtB3ekyysHbtzoqGhfpqH3XrtIG-s6akIXHqi91Z5v6MmrazlbWr2-RrvPINcvedzV4f4j2Cl16OBrOCXq5mT_P7uLFw-397HoRGyZkFxvOjcFpVmRYJ3kBVBKjKckJEbQwYikMpWEnQ3BCaJoyTFmRQSqIxkwwTtgEnWz6tq757MF3KgxkoCx1DU3vVSaDJpHQAKYb0LjGeweFasPC2v0ogtVKpVqrVCtPSgq1Vql4qJsOH_TLCvJt1eAu5MdDrn0QVDhdG-v_mmfBNZcBu9pgEGR8WXDKGwu1gdw6MJ3KG_vPIL97XJA_</recordid><startdate>19981001</startdate><enddate>19981001</enddate><creator>Campisi, B.</creator><creator>Chicco, D.</creator><creator>Vojnovic, D.</creator><creator>Phan-Tan-Luu, R.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19981001</creationdate><title>Experimental design for a pharmaceutical formulation: optimisation and robustness</title><author>Campisi, B. ; Chicco, D. ; Vojnovic, D. ; Phan-Tan-Luu, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-c77cc056f60a4dfe291ca21d1182fc8b8c22017c10412553023f6e581a0383713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Component proportion approach</topic><topic>Cosolvent mixture optimisation</topic><topic>Drug Compounding - methods</topic><topic>Drug Compounding - standards</topic><topic>Experimental mixture design</topic><topic>General pharmacology</topic><topic>Mathematically independent variable approach</topic><topic>Medical sciences</topic><topic>Models, Theoretical</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Research Design</topic><topic>Sensitivity and Specificity</topic><topic>Solubility</topic><topic>Theophylline - chemistry</topic><topic>Theophylline solubility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campisi, B.</creatorcontrib><creatorcontrib>Chicco, D.</creatorcontrib><creatorcontrib>Vojnovic, D.</creatorcontrib><creatorcontrib>Phan-Tan-Luu, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campisi, B.</au><au>Chicco, D.</au><au>Vojnovic, D.</au><au>Phan-Tan-Luu, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental design for a pharmaceutical formulation: optimisation and robustness</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>1998-10-01</date><risdate>1998</risdate><volume>18</volume><issue>1-2</issue><spage>57</spage><epage>65</epage><pages>57-65</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>In pharmaceutical industries, the formulator is usually faced with the optimisation of the excipient mixture composition aimed to prepare a product with the required characteristics. 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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 1998-10, Vol.18 (1-2), p.57-65 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Chemistry, Pharmaceutical - methods Component proportion approach Cosolvent mixture optimisation Drug Compounding - methods Drug Compounding - standards Experimental mixture design General pharmacology Mathematically independent variable approach Medical sciences Models, Theoretical Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Reproducibility of Results Research Design Sensitivity and Specificity Solubility Theophylline - chemistry Theophylline solubility |
| title | Experimental design for a pharmaceutical formulation: optimisation and robustness |
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