Hypocapnia-induced contraction of porcine airway smooth muscle

Hypocapnia constricts peripheral airways in vivo. This study investigated the role of airway smooth muscle in this phenomenon and the mechanism of hypocapnia-induced contraction in vitro. Isometric tension, intracellular pH (pHi) and intracellular free calcium concentration ([Ca2+]i) were measured i...

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Veröffentlicht in:	The European respiratory journal 1998-11, Vol.12 (5), p.1046-1052
Hauptverfasser:	Lindeman, KS, Croxton, TL, Lande, B, Hirshman, CA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bronchi - drug effects Bronchi - metabolism Bronchi - physiology Bronchodilator Agents - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Carbachol - pharmacology Carbon Dioxide - physiology Hydrogen-Ion Concentration In Vitro Techniques Isoproterenol - pharmacology Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiology Nifedipine - pharmacology Pneumology Respiratory system : syndromes and miscellaneous diseases Swine Trachea - drug effects Trachea - metabolism Trachea - physiology
Online-Zugang:	Volltext
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