Effects of the Novel Antimigraine Agent, Frovatriptan, on Coronary and Cardiac Function in Dogs

The effects of frovatriptan (VML 251/SB-209509) on coronary artery function were investigated in isolated coronary arteries from beagle dogs. Low concentrations of frovatriptan produced contraction with -logEC50 7.55 ± 0.08 (n = 11). The maximal observed contraction attained was 56 ± 7% of the contr...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1998-12, Vol.32 (6), p.995-1000
Hauptverfasser:	Parsons, Andrew A, Valocik, Richard, Koster, Paul, Raval, Pravin, Gagnon, Robert, Tilford, Nick, Feuerstein, Giora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Carbazoles - pharmacology Cardiac Output - drug effects Coronary Circulation - drug effects Dogs Drug toxicity and drugs side effects treatment Female Heart - drug effects Heart Rate - drug effects In Vitro Techniques Male Medical sciences Migraine Disorders - drug therapy Myocardial Infarction - physiopathology Pharmacology. Drug treatments Serotonin Receptor Agonists - pharmacology Toxicity: cardiovascular system Tryptamines
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