Effect of MI-D, a new mesoionic compound, on energy-linked functions of rat liver mitochondria

MI-D (4-phenyl-5-(4-nitro-cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride), a new mesoionic compound, depressed the phosphorylation efficiency of liver mitochondria as deduced from an accentuated decrease of the respiratory control coefficient and ADP/O ratio. Analysis of segments of the respi...

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Veröffentlicht in:	FEBS letters 1998-11, Vol.440 (1), p.46-50
Hauptverfasser:	Cadena, Silvia M.S.C, Carnieri, Eva G.S, Echevarria, Aurea, de Oliveira, Maria Benigna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphatases - metabolism Animals ATPase BSA, bovine serum albumin CCCP, carbonylcyanide-m-chlorophenylhydrazone Cell Respiration - drug effects Cinnamates - pharmacology DMPC, dimyristoylphosphatidylcholine DMSO, dimethylsulfoxide DNP, 2,4-dinitrophenol Dose-Response Relationship, Drug DPIP, 2,6-dichlorophenolindophenol EGTA, ethylene glycol-bis(β-aminoethylether)-N,N,N′,N′-tetraacetic acid Electron Transport - drug effects FCCP, carbonylcyanide p-trifluoromethoxyphenylhydrazone Glutamic Acid - metabolism HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid Male Membrane Potentials - drug effects Mesoionic compound Mitochondria, Liver - enzymology Mitochondria, Liver - metabolism Mitochondrial uncoupling Oxidative Phosphorylation - drug effects Oxidoreductases - metabolism Oxygen - metabolism PEP, phosphoenolpyruvate Pi, inorganic phosphate PMS, N-methyldibenzopyrazine methyl sulfate Rats Rats, Wistar Succinic Acid - metabolism Thiadiazoles Thiazoles - pharmacology Tris, tris(hydroxymethyl)aminomethane Uncoupling Agents - pharmacology Δψ, transmembrane electrical potential
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