Chlordiazepoxide Attenuates Activity-Induced Anorexia and Weight Loss in Rats
In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body weight was studied in rats on an activity anorexia (AA) regimen. For several days before CDP testing began, rats lived in activity wheels and had one 60-min meal per day. D...
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| Veröffentlicht in: | Experimental and clinical psychopharmacology 1998-11, Vol.6 (4), p.360-366 |
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| creator | Lett, Bow Tong Grant, Virginia L Koh, Ming Teng Parsons, Jason F |
| description | In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body
weight was studied in rats on an activity anorexia (AA) regimen. For
several days before CDP testing began, rats lived in activity wheels
and had one 60-min meal per day. During CDP testing, this regimen
continued except that each rat was injected with an appropriate dose
of CDP or saline 30 min before each meal. CDP enhanced food intake;
5.0 mg/kg seemed most effective. However, the CDP-induced increase
in eating did not noticeably stem weight loss. In Experiment 2, after several days of AA training, CDP (5.0 mg/kg) was tested under
less severe conditions; food remained restricted, but access to the
wheels was discontinued. Rats given CDP ate more and gained more
weight than controls. These findings suggest that benzodiazepines
such as CDP may help in treating anorexia nervosa and other
anorectic conditions in humans. |
| doi_str_mv | 10.1037/1064-1297.6.4.360 |
| format | Article |
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weight was studied in rats on an activity anorexia (AA) regimen. For
several days before CDP testing began, rats lived in activity wheels
and had one 60-min meal per day. During CDP testing, this regimen
continued except that each rat was injected with an appropriate dose
of CDP or saline 30 min before each meal. CDP enhanced food intake;
5.0 mg/kg seemed most effective. However, the CDP-induced increase
in eating did not noticeably stem weight loss. In Experiment 2, after several days of AA training, CDP (5.0 mg/kg) was tested under
less severe conditions; food remained restricted, but access to the
wheels was discontinued. Rats given CDP ate more and gained more
weight than controls. These findings suggest that benzodiazepines
such as CDP may help in treating anorexia nervosa and other
anorectic conditions in humans.</description><identifier>ISSN: 1064-1297</identifier><identifier>EISSN: 1936-2293</identifier><identifier>DOI: 10.1037/1064-1297.6.4.360</identifier><identifier>PMID: 9861550</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Activity Level ; Animal ; Animals ; Anorexia Nervosa - etiology ; Anorexia Nervosa - physiopathology ; Body Weight ; Chlordiazepoxide ; Chlordiazepoxide - pharmacology ; Eating - drug effects ; Feeding Behavior - drug effects ; Food Intake ; Male ; Motor Activity - drug effects ; Rats ; Rats, Sprague-Dawley ; Weight Loss ; Weight Loss - drug effects</subject><ispartof>Experimental and clinical psychopharmacology, 1998-11, Vol.6 (4), p.360-366</ispartof><rights>1998 American Psychological Association</rights><rights>1998, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a353t-5b6b5abc1b8d8704bbfb19d8d6083afe91386f9e49490f75cd40528c7e2c22e73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9861550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lett, Bow Tong</creatorcontrib><creatorcontrib>Grant, Virginia L</creatorcontrib><creatorcontrib>Koh, Ming Teng</creatorcontrib><creatorcontrib>Parsons, Jason F</creatorcontrib><title>Chlordiazepoxide Attenuates Activity-Induced Anorexia and Weight Loss in Rats</title><title>Experimental and clinical psychopharmacology</title><addtitle>Exp Clin Psychopharmacol</addtitle><description>In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body
weight was studied in rats on an activity anorexia (AA) regimen. For
several days before CDP testing began, rats lived in activity wheels
and had one 60-min meal per day. During CDP testing, this regimen
continued except that each rat was injected with an appropriate dose
of CDP or saline 30 min before each meal. CDP enhanced food intake;
5.0 mg/kg seemed most effective. However, the CDP-induced increase
in eating did not noticeably stem weight loss. In Experiment 2, after several days of AA training, CDP (5.0 mg/kg) was tested under
less severe conditions; food remained restricted, but access to the
wheels was discontinued. Rats given CDP ate more and gained more
weight than controls. These findings suggest that benzodiazepines
such as CDP may help in treating anorexia nervosa and other
anorectic conditions in humans.</description><subject>Activity Level</subject><subject>Animal</subject><subject>Animals</subject><subject>Anorexia Nervosa - etiology</subject><subject>Anorexia Nervosa - physiopathology</subject><subject>Body Weight</subject><subject>Chlordiazepoxide</subject><subject>Chlordiazepoxide - pharmacology</subject><subject>Eating - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Food Intake</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Weight Loss</subject><subject>Weight Loss - drug effects</subject><issn>1064-1297</issn><issn>1936-2293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LxDAQhoMo6-cP8CAUBW9dkyZNm-Oy-AUrgigeQ5pM3Szdtiap7PrrzbKrB08z8L7zzsyD0DnBY4JpcUMwZynJRDHmYzamHO-hIyIoT7NM0P3Y_-qH6Nj7BcaEUZGN0EiUnOQ5PkJP03nTOWPVN_TdyhpIJiFAO6gAPpnoYL9sWKePrRk0mGTSdg5WViWqNck72I95SGad94ltkxcV_Ck6qFXj4WxXT9Db3e3r9CGdPd8_TiezVNGchjSveJWrSpOqNGWBWVXVFRGmNByXVNUgCC15LYAJJnBd5NownGelLiDTWQYFPUHX29zedZ8D-CCX1mtoGtVCN3jJBRaclSIaL_8ZF93g2nib5JEFxXF7NJGtSbv4i4Na9s4ulVtLguWGs9xwlBuOkksmI-c4c7ELHqolmL-JHdioX2111SvZ-7VWLljdgJf9XP2l_ABr8IQE</recordid><startdate>19981101</startdate><enddate>19981101</enddate><creator>Lett, Bow Tong</creator><creator>Grant, Virginia L</creator><creator>Koh, Ming Teng</creator><creator>Parsons, Jason F</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19981101</creationdate><title>Chlordiazepoxide Attenuates Activity-Induced Anorexia and Weight Loss in Rats</title><author>Lett, Bow Tong ; Grant, Virginia L ; Koh, Ming Teng ; Parsons, Jason F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a353t-5b6b5abc1b8d8704bbfb19d8d6083afe91386f9e49490f75cd40528c7e2c22e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Activity Level</topic><topic>Animal</topic><topic>Animals</topic><topic>Anorexia Nervosa - etiology</topic><topic>Anorexia Nervosa - physiopathology</topic><topic>Body Weight</topic><topic>Chlordiazepoxide</topic><topic>Chlordiazepoxide - pharmacology</topic><topic>Eating - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Food Intake</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Weight Loss</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lett, Bow Tong</creatorcontrib><creatorcontrib>Grant, Virginia L</creatorcontrib><creatorcontrib>Koh, Ming Teng</creatorcontrib><creatorcontrib>Parsons, Jason F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lett, Bow Tong</au><au>Grant, Virginia L</au><au>Koh, Ming Teng</au><au>Parsons, Jason F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlordiazepoxide Attenuates Activity-Induced Anorexia and Weight Loss in Rats</atitle><jtitle>Experimental and clinical psychopharmacology</jtitle><addtitle>Exp Clin Psychopharmacol</addtitle><date>1998-11-01</date><risdate>1998</risdate><volume>6</volume><issue>4</issue><spage>360</spage><epage>366</epage><pages>360-366</pages><issn>1064-1297</issn><eissn>1936-2293</eissn><abstract>In Experiment 1, the effect of repeated injections of 2.5, 5.0, or 10.0 mg/kg of chlordiazepoxide (CDP) on food intake and body
weight was studied in rats on an activity anorexia (AA) regimen. For
several days before CDP testing began, rats lived in activity wheels
and had one 60-min meal per day. During CDP testing, this regimen
continued except that each rat was injected with an appropriate dose
of CDP or saline 30 min before each meal. CDP enhanced food intake;
5.0 mg/kg seemed most effective. However, the CDP-induced increase
in eating did not noticeably stem weight loss. In Experiment 2, after several days of AA training, CDP (5.0 mg/kg) was tested under
less severe conditions; food remained restricted, but access to the
wheels was discontinued. Rats given CDP ate more and gained more
weight than controls. These findings suggest that benzodiazepines
such as CDP may help in treating anorexia nervosa and other
anorectic conditions in humans.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>9861550</pmid><doi>10.1037/1064-1297.6.4.360</doi><tpages>7</tpages></addata></record> |
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| ispartof | Experimental and clinical psychopharmacology, 1998-11, Vol.6 (4), p.360-366 |
| issn | 1064-1297 1936-2293 |
| language | eng |
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| source | MEDLINE; EBSCOhost APA PsycARTICLES |
| subjects | Activity Level Animal Animals Anorexia Nervosa - etiology Anorexia Nervosa - physiopathology Body Weight Chlordiazepoxide Chlordiazepoxide - pharmacology Eating - drug effects Feeding Behavior - drug effects Food Intake Male Motor Activity - drug effects Rats Rats, Sprague-Dawley Weight Loss Weight Loss - drug effects |
| title | Chlordiazepoxide Attenuates Activity-Induced Anorexia and Weight Loss in Rats |
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