Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation
The capacity of dendritic cells (DC) to initiate immune responses is dependent on their specialized migratory and tissue homing properties. Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte‐macrophage...
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| Veröffentlicht in: | European journal of immunology 1998-12, Vol.28 (12), p.4114-4122 |
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| container_title | European journal of immunology |
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| creator | Lin, Chen‐Lung Suri, Rakesh M. Rahdon, Richard A. Austyn, Jonathan M. Roake, Justin A. |
| description | The capacity of dendritic cells (DC) to initiate immune responses is dependent on their specialized migratory and tissue homing properties. Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte‐macrophage colony‐stimulating factor and IL‐4. These cells exhibited potent chemotaxis and TEM responses to the CC chemokines macrophage inflammatory protein (MIP)‐1α, MIP‐1β, RANTES, and monocyte chemotactic protein‐3, and weak responses to the CC chemokine MIP‐3β and the CXC chemokine stromal cell‐derived factor (SDF)‐1α. Maturation of DC induced by culture in lipopolysaccharide, TNF‐α or IL‐1β reduced or abolished responses to the former CC chemokines but markedly enhanced responses to MIP‐3β and SDF‐1α. This correlated with changes in chemokine receptor expression: CCR5 expression was reduced while CXCR4 expression was enhanced. These findings suggest two stages for regulation of DC migration in which one set of chemokines may regulate recruitment into or within tissues, and another egress from the tissues. |
| doi_str_mv | 10.1002/(SICI)1521-4141(199812)28:12<4114::AID-IMMU4114>3.0.CO;2-C |
| format | Article |
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Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte‐macrophage colony‐stimulating factor and IL‐4. These cells exhibited potent chemotaxis and TEM responses to the CC chemokines macrophage inflammatory protein (MIP)‐1α, MIP‐1β, RANTES, and monocyte chemotactic protein‐3, and weak responses to the CC chemokine MIP‐3β and the CXC chemokine stromal cell‐derived factor (SDF)‐1α. Maturation of DC induced by culture in lipopolysaccharide, TNF‐α or IL‐1β reduced or abolished responses to the former CC chemokines but markedly enhanced responses to MIP‐3β and SDF‐1α. This correlated with changes in chemokine receptor expression: CCR5 expression was reduced while CXCR4 expression was enhanced. 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Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte‐macrophage colony‐stimulating factor and IL‐4. These cells exhibited potent chemotaxis and TEM responses to the CC chemokines macrophage inflammatory protein (MIP)‐1α, MIP‐1β, RANTES, and monocyte chemotactic protein‐3, and weak responses to the CC chemokine MIP‐3β and the CXC chemokine stromal cell‐derived factor (SDF)‐1α. Maturation of DC induced by culture in lipopolysaccharide, TNF‐α or IL‐1β reduced or abolished responses to the former CC chemokines but markedly enhanced responses to MIP‐3β and SDF‐1α. This correlated with changes in chemokine receptor expression: CCR5 expression was reduced while CXCR4 expression was enhanced. These findings suggest two stages for regulation of DC migration in which one set of chemokines may regulate recruitment into or within tissues, and another egress from the tissues.</description><subject>Cell Differentiation - immunology</subject><subject>Cells, Cultured</subject><subject>Chemokine</subject><subject>Chemokines - immunology</subject><subject>Chemotaxis</subject><subject>Chemotaxis - immunology</subject><subject>Dendritic cell</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - immunology</subject><subject>Endothelium, Vascular - cytology</subject><subject>Humans</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Maturation</subject><subject>Receptors, Chemokine - immunology</subject><subject>Transendothelial migration</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURi1EVYbCT0DKCrWLDH4lsQeEVFJoI7WaBXTDgivH8bSGPIrtiI7653GU6WwQ6saWfc_9rq2D0CeClwRj-u74a1VWJySjJOWEk2MipSD0hIoVoR84IXy1Oq3O0urq6no6fWRLvCzX72laPkOLfdtztMCY8JRKgV-gl97_xBjLPJOH6FCKnDJeLNDDmekbZ4PViTZtm-hb0w1B3VufqL5JglO9j8QQbk1rVZt09sapYIc-Uc4ktm9GbZqk3iaN9cH2OswJv2xv5oQJc-ZmbFWIYOzrVBjniFfoYKNab17v9iN0_eXzt_IivVyfV-XpZao5Lnja8NywQlMhJeM8w1plRtQbrKliRtOs4CLHMhO1xk1T10RiTbgxYpNRwYTK2RF6O-feueH3aHyAzvrpt6o3w-ghl7FdsuJJkBSk4JGL4PcZ1G7w3pkN3DnbKbcFgmFSCDAphMkFTC5gVghUQFwnaQBRITwqBAYYyjVQKGP4m90rxrozzT565yzWf8z1P7Y1238mPzn4P3P3d-wvP0262A</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>Lin, Chen‐Lung</creator><creator>Suri, Rakesh M.</creator><creator>Rahdon, Richard A.</creator><creator>Austyn, Jonathan M.</creator><creator>Roake, Justin A.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199812</creationdate><title>Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation</title><author>Lin, Chen‐Lung ; Suri, Rakesh M. ; Rahdon, Richard A. ; Austyn, Jonathan M. ; Roake, Justin A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4074-d46e37c289934450ca5e8bf0c2a3ec2574860958bc0ddbb190c14ee8f52838a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Cell Differentiation - immunology</topic><topic>Cells, Cultured</topic><topic>Chemokine</topic><topic>Chemokines - immunology</topic><topic>Chemotaxis</topic><topic>Chemotaxis - immunology</topic><topic>Dendritic cell</topic><topic>Dendritic Cells - cytology</topic><topic>Dendritic Cells - immunology</topic><topic>Endothelium, Vascular - cytology</topic><topic>Humans</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Maturation</topic><topic>Receptors, Chemokine - immunology</topic><topic>Transendothelial migration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chen‐Lung</creatorcontrib><creatorcontrib>Suri, Rakesh M.</creatorcontrib><creatorcontrib>Rahdon, Richard A.</creatorcontrib><creatorcontrib>Austyn, Jonathan M.</creatorcontrib><creatorcontrib>Roake, Justin A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chen‐Lung</au><au>Suri, Rakesh M.</au><au>Rahdon, Richard A.</au><au>Austyn, Jonathan M.</au><au>Roake, Justin A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1998-12</date><risdate>1998</risdate><volume>28</volume><issue>12</issue><spage>4114</spage><epage>4122</epage><pages>4114-4122</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The capacity of dendritic cells (DC) to initiate immune responses is dependent on their specialized migratory and tissue homing properties. Chemotaxis and transendothelial migration (TEM) of DC were studied in vitro. Immature DC were generated by culture of human monocytes in granulocyte‐macrophage colony‐stimulating factor and IL‐4. These cells exhibited potent chemotaxis and TEM responses to the CC chemokines macrophage inflammatory protein (MIP)‐1α, MIP‐1β, RANTES, and monocyte chemotactic protein‐3, and weak responses to the CC chemokine MIP‐3β and the CXC chemokine stromal cell‐derived factor (SDF)‐1α. Maturation of DC induced by culture in lipopolysaccharide, TNF‐α or IL‐1β reduced or abolished responses to the former CC chemokines but markedly enhanced responses to MIP‐3β and SDF‐1α. This correlated with changes in chemokine receptor expression: CCR5 expression was reduced while CXCR4 expression was enhanced. These findings suggest two stages for regulation of DC migration in which one set of chemokines may regulate recruitment into or within tissues, and another egress from the tissues.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>9862347</pmid><doi>10.1002/(SICI)1521-4141(199812)28:12<4114::AID-IMMU4114>3.0.CO;2-C</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of immunology, 1998-12, Vol.28 (12), p.4114-4122 |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Cell Differentiation - immunology Cells, Cultured Chemokine Chemokines - immunology Chemotaxis Chemotaxis - immunology Dendritic cell Dendritic Cells - cytology Dendritic Cells - immunology Endothelium, Vascular - cytology Humans Lipopolysaccharides - pharmacology Maturation Receptors, Chemokine - immunology Transendothelial migration |
| title | Dendritic cell chemotaxis and transendothelial migration are induced by distinct chemokines and are regulated on maturation |
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