Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis
We report a case of aggressive natural killer (NK) cell lymphoma in an 82 year old man who first presented 10 years earlier with neutropenia in association with a large granular lymphocyte (LGL) lymphocytosis. The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological...
Gespeichert in:
Veröffentlicht in: | Leukemia & lymphoma 1998, Vol.31 (3-4), p.417-421 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 421 |
---|---|
container_issue | 3-4 |
container_start_page | 417 |
container_title | Leukemia & lymphoma |
container_volume | 31 |
creator | De Lord, Corinne Mercieca, Jane Ashton-Key, Margaret Singh, Linda Ryley, Sarah Isaacson, Peter Catovsky, Daniel |
description | We report a case of aggressive natural killer (NK) cell lymphoma in an 82 year old man who first presented 10 years earlier with neutropenia in association with a large granular lymphocyte (LGL) lymphocytosis. The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological characteristics (CD3-CD56+) found on skin biopsy of one of multiple skin nodules which subsequently developed in association with splenomegaly, thrombocytopenia and continuing neutropenia. In addition there was BM infiltration and a cytogenetic abnormality [add(6)(p25)] was detected. Combination chemotherapy led to an initial clinical response but a relapse occurred shortly afterwards and the patient died 8 months later from infection whilst neutropenic following re-introduction of chemotherapy. Previously reported cases of aggressive NK cell lymphoma have shown a young male predominance with a rapidly progressive clinical course and without evidence of a preceding chronic phase of LGL lymphocytosis and neutropenia. |
doi_str_mv | 10.3109/10428199809059236 |
format | Article |
fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_69095923</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69095923</sourcerecordid><originalsourceid>FETCH-LOGICAL-c401t-a55e1c0f185fc301239a94664b0b783484730a1edfef8537236f0c94a499fe563</originalsourceid><addsrcrecordid>eNp9kMFu1DAQhi0EKm3hATgg-cQtZRw72VhwWa2gRawKh3LgFM06411XSbzYDlWOvDle7QqEEJw80vz_J8_H2AsBV1KAfi1AlY3QugENlS5l_YidCyh1USqQjw-zKoscUE_ZRYz3ADlVl2fsTDe1LmFxzn4st9tAMbrvxG8_8hX1PV_Pw37nB-SfAxnqqOObmSO_o5F_JQz8xsXkw8y95bc0peD3NDrkyxi9cZhy_sGlHV9j2BK_DjhOfW4dqWZO9Hv00cVn7InFPtLz03vJvrx_d7e6Kdafrj-sluvCKBCpwKoiYcCKprJGgiilRq3qWm1gs2ikatRCAgrqLNmmkossw4LRCpXWlqpaXrJXR-4--G8TxdQOLpp8L47kp9jWGvTBYQ6KY9AEH2Mg2-6DGzDMrYD2oL39S3vuvDzBp81A3a_GyXPevz3u3Wh9GPDBh75rE869DzYbMi4e0P_Gv_mjviPs085goPbeT2HM3v7zuZ-SHaNZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69095923</pqid></control><display><type>article</type><title>Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis</title><source>Taylor & Francis</source><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><creator>De Lord, Corinne ; Mercieca, Jane ; Ashton-Key, Margaret ; Singh, Linda ; Ryley, Sarah ; Isaacson, Peter ; Catovsky, Daniel</creator><creatorcontrib>De Lord, Corinne ; Mercieca, Jane ; Ashton-Key, Margaret ; Singh, Linda ; Ryley, Sarah ; Isaacson, Peter ; Catovsky, Daniel</creatorcontrib><description>We report a case of aggressive natural killer (NK) cell lymphoma in an 82 year old man who first presented 10 years earlier with neutropenia in association with a large granular lymphocyte (LGL) lymphocytosis. The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological characteristics (CD3-CD56+) found on skin biopsy of one of multiple skin nodules which subsequently developed in association with splenomegaly, thrombocytopenia and continuing neutropenia. In addition there was BM infiltration and a cytogenetic abnormality [add(6)(p25)] was detected. Combination chemotherapy led to an initial clinical response but a relapse occurred shortly afterwards and the patient died 8 months later from infection whilst neutropenic following re-introduction of chemotherapy. Previously reported cases of aggressive NK cell lymphoma have shown a young male predominance with a rapidly progressive clinical course and without evidence of a preceding chronic phase of LGL lymphocytosis and neutropenia.</description><identifier>ISSN: 1042-8194</identifier><identifier>EISSN: 1029-2403</identifier><identifier>DOI: 10.3109/10428199809059236</identifier><identifier>PMID: 9869207</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Aged ; Aged, 80 and over ; aggressive NK cell lymphoma ; Chromosome Aberrations ; Chromosomes, Human, Pair 6 ; Humans ; Killer Cells, Natural - pathology ; LGL lymphocytosis ; Lymphocytosis - complications ; Lymphoma, T-Cell - etiology ; Lymphoma, T-Cell - genetics ; Lymphoma, T-Cell - pathology ; Lymphoma, T-Cell - physiopathology ; Male ; neutropenia ; Neutropenia - complications ; Skin Neoplasms - etiology ; Skin Neoplasms - genetics ; Skin Neoplasms - pathology ; Skin Neoplasms - physiopathology</subject><ispartof>Leukemia & lymphoma, 1998, Vol.31 (3-4), p.417-421</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-a55e1c0f185fc301239a94664b0b783484730a1edfef8537236f0c94a499fe563</citedby><cites>FETCH-LOGICAL-c401t-a55e1c0f185fc301239a94664b0b783484730a1edfef8537236f0c94a499fe563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10428199809059236$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10428199809059236$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27902,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9869207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Lord, Corinne</creatorcontrib><creatorcontrib>Mercieca, Jane</creatorcontrib><creatorcontrib>Ashton-Key, Margaret</creatorcontrib><creatorcontrib>Singh, Linda</creatorcontrib><creatorcontrib>Ryley, Sarah</creatorcontrib><creatorcontrib>Isaacson, Peter</creatorcontrib><creatorcontrib>Catovsky, Daniel</creatorcontrib><title>Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis</title><title>Leukemia & lymphoma</title><addtitle>Leuk Lymphoma</addtitle><description>We report a case of aggressive natural killer (NK) cell lymphoma in an 82 year old man who first presented 10 years earlier with neutropenia in association with a large granular lymphocyte (LGL) lymphocytosis. The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological characteristics (CD3-CD56+) found on skin biopsy of one of multiple skin nodules which subsequently developed in association with splenomegaly, thrombocytopenia and continuing neutropenia. In addition there was BM infiltration and a cytogenetic abnormality [add(6)(p25)] was detected. Combination chemotherapy led to an initial clinical response but a relapse occurred shortly afterwards and the patient died 8 months later from infection whilst neutropenic following re-introduction of chemotherapy. Previously reported cases of aggressive NK cell lymphoma have shown a young male predominance with a rapidly progressive clinical course and without evidence of a preceding chronic phase of LGL lymphocytosis and neutropenia.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aggressive NK cell lymphoma</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 6</subject><subject>Humans</subject><subject>Killer Cells, Natural - pathology</subject><subject>LGL lymphocytosis</subject><subject>Lymphocytosis - complications</subject><subject>Lymphoma, T-Cell - etiology</subject><subject>Lymphoma, T-Cell - genetics</subject><subject>Lymphoma, T-Cell - pathology</subject><subject>Lymphoma, T-Cell - physiopathology</subject><subject>Male</subject><subject>neutropenia</subject><subject>Neutropenia - complications</subject><subject>Skin Neoplasms - etiology</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - physiopathology</subject><issn>1042-8194</issn><issn>1029-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi0EKm3hATgg-cQtZRw72VhwWa2gRawKh3LgFM06411XSbzYDlWOvDle7QqEEJw80vz_J8_H2AsBV1KAfi1AlY3QugENlS5l_YidCyh1USqQjw-zKoscUE_ZRYz3ADlVl2fsTDe1LmFxzn4st9tAMbrvxG8_8hX1PV_Pw37nB-SfAxnqqOObmSO_o5F_JQz8xsXkw8y95bc0peD3NDrkyxi9cZhy_sGlHV9j2BK_DjhOfW4dqWZO9Hv00cVn7InFPtLz03vJvrx_d7e6Kdafrj-sluvCKBCpwKoiYcCKprJGgiilRq3qWm1gs2ikatRCAgrqLNmmkossw4LRCpXWlqpaXrJXR-4--G8TxdQOLpp8L47kp9jWGvTBYQ6KY9AEH2Mg2-6DGzDMrYD2oL39S3vuvDzBp81A3a_GyXPevz3u3Wh9GPDBh75rE869DzYbMi4e0P_Gv_mjviPs085goPbeT2HM3v7zuZ-SHaNZ</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>De Lord, Corinne</creator><creator>Mercieca, Jane</creator><creator>Ashton-Key, Margaret</creator><creator>Singh, Linda</creator><creator>Ryley, Sarah</creator><creator>Isaacson, Peter</creator><creator>Catovsky, Daniel</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1998</creationdate><title>Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis</title><author>De Lord, Corinne ; Mercieca, Jane ; Ashton-Key, Margaret ; Singh, Linda ; Ryley, Sarah ; Isaacson, Peter ; Catovsky, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-a55e1c0f185fc301239a94664b0b783484730a1edfef8537236f0c94a499fe563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aggressive NK cell lymphoma</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 6</topic><topic>Humans</topic><topic>Killer Cells, Natural - pathology</topic><topic>LGL lymphocytosis</topic><topic>Lymphocytosis - complications</topic><topic>Lymphoma, T-Cell - etiology</topic><topic>Lymphoma, T-Cell - genetics</topic><topic>Lymphoma, T-Cell - pathology</topic><topic>Lymphoma, T-Cell - physiopathology</topic><topic>Male</topic><topic>neutropenia</topic><topic>Neutropenia - complications</topic><topic>Skin Neoplasms - etiology</topic><topic>Skin Neoplasms - genetics</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Lord, Corinne</creatorcontrib><creatorcontrib>Mercieca, Jane</creatorcontrib><creatorcontrib>Ashton-Key, Margaret</creatorcontrib><creatorcontrib>Singh, Linda</creatorcontrib><creatorcontrib>Ryley, Sarah</creatorcontrib><creatorcontrib>Isaacson, Peter</creatorcontrib><creatorcontrib>Catovsky, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia & lymphoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Lord, Corinne</au><au>Mercieca, Jane</au><au>Ashton-Key, Margaret</au><au>Singh, Linda</au><au>Ryley, Sarah</au><au>Isaacson, Peter</au><au>Catovsky, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis</atitle><jtitle>Leukemia & lymphoma</jtitle><addtitle>Leuk Lymphoma</addtitle><date>1998</date><risdate>1998</risdate><volume>31</volume><issue>3-4</issue><spage>417</spage><epage>421</epage><pages>417-421</pages><issn>1042-8194</issn><eissn>1029-2403</eissn><abstract>We report a case of aggressive natural killer (NK) cell lymphoma in an 82 year old man who first presented 10 years earlier with neutropenia in association with a large granular lymphocyte (LGL) lymphocytosis. The diagnosis of NK cell lymphoma was made on the basis of morphological and immunological characteristics (CD3-CD56+) found on skin biopsy of one of multiple skin nodules which subsequently developed in association with splenomegaly, thrombocytopenia and continuing neutropenia. In addition there was BM infiltration and a cytogenetic abnormality [add(6)(p25)] was detected. Combination chemotherapy led to an initial clinical response but a relapse occurred shortly afterwards and the patient died 8 months later from infection whilst neutropenic following re-introduction of chemotherapy. Previously reported cases of aggressive NK cell lymphoma have shown a young male predominance with a rapidly progressive clinical course and without evidence of a preceding chronic phase of LGL lymphocytosis and neutropenia.</abstract><cop>United States</cop><pub>Informa UK Ltd</pub><pmid>9869207</pmid><doi>10.3109/10428199809059236</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1042-8194 |
ispartof | Leukemia & lymphoma, 1998, Vol.31 (3-4), p.417-421 |
issn | 1042-8194 1029-2403 |
language | eng |
recordid | cdi_proquest_miscellaneous_69095923 |
source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
subjects | Aged Aged, 80 and over aggressive NK cell lymphoma Chromosome Aberrations Chromosomes, Human, Pair 6 Humans Killer Cells, Natural - pathology LGL lymphocytosis Lymphocytosis - complications Lymphoma, T-Cell - etiology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - pathology Lymphoma, T-Cell - physiopathology Male neutropenia Neutropenia - complications Skin Neoplasms - etiology Skin Neoplasms - genetics Skin Neoplasms - pathology Skin Neoplasms - physiopathology |
title | Aggressive NK Cell Lymphoma Preceded by a Ten Year History of Neutropenia Associated with Large Granular Lymphocyte Lymphocytosis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T06%3A55%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aggressive%20NK%20Cell%20Lymphoma%20Preceded%20by%20a%20Ten%20Year%20History%20of%20Neutropenia%20Associated%20with%20Large%20Granular%20Lymphocyte%20Lymphocytosis&rft.jtitle=Leukemia%20&%20lymphoma&rft.au=De%20Lord,%20Corinne&rft.date=1998&rft.volume=31&rft.issue=3-4&rft.spage=417&rft.epage=421&rft.pages=417-421&rft.issn=1042-8194&rft.eissn=1029-2403&rft_id=info:doi/10.3109/10428199809059236&rft_dat=%3Cproquest_infor%3E69095923%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69095923&rft_id=info:pmid/9869207&rfr_iscdi=true |