Change of cerebral metabolism rate of glucose of cerebral white matter in Alzheimer's disease: a study with statistical parametric mapping software
To study the change of cerebral metabolism rate of glucose (CMRglc) of cerebral white matter in Alzheimer's Disease. Positron emission tomography (PET) was performed on 13 AD patients, 6 with behavioral and psychological symptoms of dementia (BPSD) and 7 without BPSD, and 10 healthy controls. T...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2007-10, Vol.87 (39), p.2777-2779 |
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| container_title | Zhong hua yi xue za zhi |
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| creator | Cao, Qiu-yun Guo, Wan-hua Yang, Hai-long Shen, Di-wen Zhao, Peng Jiang, Kai-da Zhang, Ming-yuan Xiao, Shi-fu |
| description | To study the change of cerebral metabolism rate of glucose (CMRglc) of cerebral white matter in Alzheimer's Disease.
Positron emission tomography (PET) was performed on 13 AD patients, 6 with behavioral and psychological symptoms of dementia (BPSD) and 7 without BPSD, and 10 healthy controls. The regional cerebral metabolism of glucose (rCMRglc) of some brain regions and nuclei were detected.
(1) The rCMRglc of the cerebral white matter decreased extensively in the AD patients, especially in the right frontal lobe, superior gyrus of the left frontal lobe (P = 0.001). (2) The rCMRglc of subcortical white matter of the left medial prefrontal lobe and the left cuneus of occipital lobe increased in the AD patients. (3) The levels of rCMRglc of the subcortical white matter of both side middle occipital lobe, left cuneus of occipital lobe, right inferior parietal lobule, left fusiform gyrus of temporal lobe and the left medial prefrontal lobe were all significantly higher in the AD patients with BPSD than in those |
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Positron emission tomography (PET) was performed on 13 AD patients, 6 with behavioral and psychological symptoms of dementia (BPSD) and 7 without BPSD, and 10 healthy controls. The regional cerebral metabolism of glucose (rCMRglc) of some brain regions and nuclei were detected.
(1) The rCMRglc of the cerebral white matter decreased extensively in the AD patients, especially in the right frontal lobe, superior gyrus of the left frontal lobe (P = 0.001). (2) The rCMRglc of subcortical white matter of the left medial prefrontal lobe and the left cuneus of occipital lobe increased in the AD patients. (3) The levels of rCMRglc of the subcortical white matter of both side middle occipital lobe, left cuneus of occipital lobe, right inferior parietal lobule, left fusiform gyrus of temporal lobe and the left medial prefrontal lobe were all significantly higher in the AD patients with BPSD than in those</description><identifier>ISSN: 0376-2491</identifier><identifier>PMID: 18167271</identifier><language>chi</language><publisher>China</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Cerebral Cortex - metabolism ; Female ; Glucose - metabolism ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography - statistics & numerical data ; Software</subject><ispartof>Zhong hua yi xue za zhi, 2007-10, Vol.87 (39), p.2777-2779</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18167271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Qiu-yun</creatorcontrib><creatorcontrib>Guo, Wan-hua</creatorcontrib><creatorcontrib>Yang, Hai-long</creatorcontrib><creatorcontrib>Shen, Di-wen</creatorcontrib><creatorcontrib>Zhao, Peng</creatorcontrib><creatorcontrib>Jiang, Kai-da</creatorcontrib><creatorcontrib>Zhang, Ming-yuan</creatorcontrib><creatorcontrib>Xiao, Shi-fu</creatorcontrib><title>Change of cerebral metabolism rate of glucose of cerebral white matter in Alzheimer's disease: a study with statistical parametric mapping software</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To study the change of cerebral metabolism rate of glucose (CMRglc) of cerebral white matter in Alzheimer's Disease.
Positron emission tomography (PET) was performed on 13 AD patients, 6 with behavioral and psychological symptoms of dementia (BPSD) and 7 without BPSD, and 10 healthy controls. The regional cerebral metabolism of glucose (rCMRglc) of some brain regions and nuclei were detected.
(1) The rCMRglc of the cerebral white matter decreased extensively in the AD patients, especially in the right frontal lobe, superior gyrus of the left frontal lobe (P = 0.001). (2) The rCMRglc of subcortical white matter of the left medial prefrontal lobe and the left cuneus of occipital lobe increased in the AD patients. (3) The levels of rCMRglc of the subcortical white matter of both side middle occipital lobe, left cuneus of occipital lobe, right inferior parietal lobule, left fusiform gyrus of temporal lobe and the left medial prefrontal lobe were all significantly higher in the AD patients with BPSD than in those</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Female</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography - statistics & numerical data</subject><subject>Software</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRb0A0ar0F5BXsIpkO26csKsqXlIlNrCOxs64sZQXtqOq_AY_jAVlwWpGc8_c0dwLsmS5KjIhK74g6xCcZlLllWCCX5EFL3mhhOJL8rVrYTggHS016FF76GiPEfTYudBTD_FHO3SzGcN_7Ni6JPYQI3rqBrrtPlt0Pfq7QBsXEALeU6Ahzs2JHl1sUwvRhehM2p7AQzrknUkW0-SGAw2jjUfweE0uLXQB1-e6Iu-PD2-752z_-vSy2-6ziQsZM8m0wY0tATQICZD-SyMtuBWSldJyxTfa5kxKo0qloNRYCdukHDTboLT5itz--k5-_JgxxLp3wWDXwYDjHOqiYpVUBU_gzRmcdY9NPXnXgz_VfzHm315jcZc</recordid><startdate>20071023</startdate><enddate>20071023</enddate><creator>Cao, Qiu-yun</creator><creator>Guo, Wan-hua</creator><creator>Yang, Hai-long</creator><creator>Shen, Di-wen</creator><creator>Zhao, Peng</creator><creator>Jiang, Kai-da</creator><creator>Zhang, Ming-yuan</creator><creator>Xiao, Shi-fu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20071023</creationdate><title>Change of cerebral metabolism rate of glucose of cerebral white matter in Alzheimer's disease: a study with statistical parametric mapping software</title><author>Cao, Qiu-yun ; Guo, Wan-hua ; Yang, Hai-long ; Shen, Di-wen ; Zhao, Peng ; Jiang, Kai-da ; Zhang, Ming-yuan ; Xiao, Shi-fu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-40bce5f8aaba24aa47340bb21f24084f1715bf3044c7877a8be92fd047b05e4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Female</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography - statistics & numerical data</topic><topic>Software</topic><toplevel>online_resources</toplevel><creatorcontrib>Cao, Qiu-yun</creatorcontrib><creatorcontrib>Guo, Wan-hua</creatorcontrib><creatorcontrib>Yang, Hai-long</creatorcontrib><creatorcontrib>Shen, Di-wen</creatorcontrib><creatorcontrib>Zhao, Peng</creatorcontrib><creatorcontrib>Jiang, Kai-da</creatorcontrib><creatorcontrib>Zhang, Ming-yuan</creatorcontrib><creatorcontrib>Xiao, Shi-fu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Qiu-yun</au><au>Guo, Wan-hua</au><au>Yang, Hai-long</au><au>Shen, Di-wen</au><au>Zhao, Peng</au><au>Jiang, Kai-da</au><au>Zhang, Ming-yuan</au><au>Xiao, Shi-fu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Change of cerebral metabolism rate of glucose of cerebral white matter in Alzheimer's disease: a study with statistical parametric mapping software</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2007-10-23</date><risdate>2007</risdate><volume>87</volume><issue>39</issue><spage>2777</spage><epage>2779</epage><pages>2777-2779</pages><issn>0376-2491</issn><abstract>To study the change of cerebral metabolism rate of glucose (CMRglc) of cerebral white matter in Alzheimer's Disease.
Positron emission tomography (PET) was performed on 13 AD patients, 6 with behavioral and psychological symptoms of dementia (BPSD) and 7 without BPSD, and 10 healthy controls. The regional cerebral metabolism of glucose (rCMRglc) of some brain regions and nuclei were detected.
(1) The rCMRglc of the cerebral white matter decreased extensively in the AD patients, especially in the right frontal lobe, superior gyrus of the left frontal lobe (P = 0.001). (2) The rCMRglc of subcortical white matter of the left medial prefrontal lobe and the left cuneus of occipital lobe increased in the AD patients. (3) The levels of rCMRglc of the subcortical white matter of both side middle occipital lobe, left cuneus of occipital lobe, right inferior parietal lobule, left fusiform gyrus of temporal lobe and the left medial prefrontal lobe were all significantly higher in the AD patients with BPSD than in those</abstract><cop>China</cop><pmid>18167271</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Zhong hua yi xue za zhi, 2007-10, Vol.87 (39), p.2777-2779 |
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| language | chi |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer Disease - pathology Cerebral Cortex - metabolism Female Glucose - metabolism Humans Male Middle Aged Positron-Emission Tomography - statistics & numerical data Software |
| title | Change of cerebral metabolism rate of glucose of cerebral white matter in Alzheimer's disease: a study with statistical parametric mapping software |
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