TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site

CD43, a large highly glycosylated molecule, is arguably the most abundant molecule on the surface of T cells. Nevertheless, the function of CD43 remains unclear. Utilizing fluorescence microscopy, we find that CD43 is excluded from the T cell-APC contact site. This exclusion is Ag dependent since op...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-12, Vol.161 (12), p.6459-6462
Hauptverfasser:	Sperling, A I, Sedy, J R, Manjunath, N, Kupfer, A, Ardman, B, Burkhardt, J K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells - immunology Antigens, CD Cell Communication Cell Membrane - immunology Cell Membrane - metabolism Humans Leukocyte Common Antigens - analysis Leukosialin Lymphocyte Activation Macromolecular Substances Motion Receptors, Antigen, T-Cell - immunology Sialoglycoproteins - metabolism Signal Transduction T-Lymphocytes - immunology
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