Factors associated with the severity of liver damage in chronic hepatitis C
Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage. T...
Gespeichert in:
| Veröffentlicht in: | Revista medíca de Chile 2005-11, Vol.133 (11), p.1311-1316 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | spa |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1316 |
|---|---|
| container_issue | 11 |
| container_start_page | 1311 |
| container_title | Revista medíca de Chile |
| container_volume | 133 |
| creator | Orellana N, Ivonne Poniachik T, Jaime Smok S, Gladys Madrid S, Ana María Menéndez A, Alejandra Tobar A, Eduardo Brahm B, Javier |
| description | Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage.
To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection.
Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed.
Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_69093719</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17199714</sourcerecordid><originalsourceid>FETCH-LOGICAL-p170t-955f839e91c51bec26f963aaebb0ff1968e97cc7657bc941b5b132b43921a46d3</originalsourceid><addsrcrecordid>eNqF0L1OwzAUBWAPIFoKr4A8sUWyY8fOHVFEAVGJBebIdq6JUf6IHVDfnkiUmemc4dMZzhnZMiZkBmWpN-Qyxg_Gcq14eUE2XEmpykJuyfPeuDTOkZoYRxdMwoZ-h9TS1CKN-IVzSEc6etqFtdPG9OYdaRioa-dxCI62OJkUUoi0uiLn3nQRr0-5I2_7-9fqMTu8PDxVd4ds4pqlDIrClwIQuCu4RZcrD0oYg9Yy7zmoEkE7p1WhrQPJbWG5yK0UkHMjVSN25PZ3d5rHzwVjqvsQHXadGXBcYq2AgdAc_oV8RaC5XOHNCS62x6ae5tCb-Vj__SR-ANBxYvc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17199714</pqid></control><display><type>article</type><title>Factors associated with the severity of liver damage in chronic hepatitis C</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Orellana N, Ivonne ; Poniachik T, Jaime ; Smok S, Gladys ; Madrid S, Ana María ; Menéndez A, Alejandra ; Tobar A, Eduardo ; Brahm B, Javier</creator><creatorcontrib>Orellana N, Ivonne ; Poniachik T, Jaime ; Smok S, Gladys ; Madrid S, Ana María ; Menéndez A, Alejandra ; Tobar A, Eduardo ; Brahm B, Javier</creatorcontrib><description>Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage.
To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection.
Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed.
Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p <0,001). No association between the severity of liver damage and the degree of steatosis, hemosiderosis, body mass index or alcohol intake, was observed. The frequency of diabetes mellitus increased along with pathological staging (3, 15 and 30% in stages I, II and III, respectively, p <0,05).
This study confirms that severity of chronic hepatitis C is associated with age and the presence of diabetes mellitus.</description><identifier>ISSN: 0034-9887</identifier><identifier>PMID: 16446854</identifier><language>spa</language><publisher>Chile</publisher><subject>Adult ; Aged ; Alcohol Drinking - adverse effects ; Biopsy ; Body Mass Index ; Diabetes Complications ; Fatty Liver - pathology ; Female ; Hemosiderosis - etiology ; Hemosiderosis - pathology ; Hepatitis C virus ; Hepatitis C, Chronic - classification ; Hepatitis C, Chronic - pathology ; Humans ; Liver Cirrhosis - pathology ; Male ; Middle Aged ; Overweight ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Revista medíca de Chile, 2005-11, Vol.133 (11), p.1311-1316</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16446854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orellana N, Ivonne</creatorcontrib><creatorcontrib>Poniachik T, Jaime</creatorcontrib><creatorcontrib>Smok S, Gladys</creatorcontrib><creatorcontrib>Madrid S, Ana María</creatorcontrib><creatorcontrib>Menéndez A, Alejandra</creatorcontrib><creatorcontrib>Tobar A, Eduardo</creatorcontrib><creatorcontrib>Brahm B, Javier</creatorcontrib><title>Factors associated with the severity of liver damage in chronic hepatitis C</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage.
To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection.
Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed.
Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p <0,001). No association between the severity of liver damage and the degree of steatosis, hemosiderosis, body mass index or alcohol intake, was observed. The frequency of diabetes mellitus increased along with pathological staging (3, 15 and 30% in stages I, II and III, respectively, p <0,05).
This study confirms that severity of chronic hepatitis C is associated with age and the presence of diabetes mellitus.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Diabetes Complications</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Hemosiderosis - etiology</subject><subject>Hemosiderosis - pathology</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - classification</subject><subject>Hepatitis C, Chronic - pathology</subject><subject>Humans</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Overweight</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>0034-9887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0L1OwzAUBWAPIFoKr4A8sUWyY8fOHVFEAVGJBebIdq6JUf6IHVDfnkiUmemc4dMZzhnZMiZkBmWpN-Qyxg_Gcq14eUE2XEmpykJuyfPeuDTOkZoYRxdMwoZ-h9TS1CKN-IVzSEc6etqFtdPG9OYdaRioa-dxCI62OJkUUoi0uiLn3nQRr0-5I2_7-9fqMTu8PDxVd4ds4pqlDIrClwIQuCu4RZcrD0oYg9Yy7zmoEkE7p1WhrQPJbWG5yK0UkHMjVSN25PZ3d5rHzwVjqvsQHXadGXBcYq2AgdAc_oV8RaC5XOHNCS62x6ae5tCb-Vj__SR-ANBxYvc</recordid><startdate>200511</startdate><enddate>200511</enddate><creator>Orellana N, Ivonne</creator><creator>Poniachik T, Jaime</creator><creator>Smok S, Gladys</creator><creator>Madrid S, Ana María</creator><creator>Menéndez A, Alejandra</creator><creator>Tobar A, Eduardo</creator><creator>Brahm B, Javier</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200511</creationdate><title>Factors associated with the severity of liver damage in chronic hepatitis C</title><author>Orellana N, Ivonne ; Poniachik T, Jaime ; Smok S, Gladys ; Madrid S, Ana María ; Menéndez A, Alejandra ; Tobar A, Eduardo ; Brahm B, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p170t-955f839e91c51bec26f963aaebb0ff1968e97cc7657bc941b5b132b43921a46d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>Diabetes Complications</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Hemosiderosis - etiology</topic><topic>Hemosiderosis - pathology</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - classification</topic><topic>Hepatitis C, Chronic - pathology</topic><topic>Humans</topic><topic>Liver Cirrhosis - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Overweight</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orellana N, Ivonne</creatorcontrib><creatorcontrib>Poniachik T, Jaime</creatorcontrib><creatorcontrib>Smok S, Gladys</creatorcontrib><creatorcontrib>Madrid S, Ana María</creatorcontrib><creatorcontrib>Menéndez A, Alejandra</creatorcontrib><creatorcontrib>Tobar A, Eduardo</creatorcontrib><creatorcontrib>Brahm B, Javier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orellana N, Ivonne</au><au>Poniachik T, Jaime</au><au>Smok S, Gladys</au><au>Madrid S, Ana María</au><au>Menéndez A, Alejandra</au><au>Tobar A, Eduardo</au><au>Brahm B, Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with the severity of liver damage in chronic hepatitis C</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2005-11</date><risdate>2005</risdate><volume>133</volume><issue>11</issue><spage>1311</spage><epage>1316</epage><pages>1311-1316</pages><issn>0034-9887</issn><abstract>Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage.
To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection.
Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed.
Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p <0,001). No association between the severity of liver damage and the degree of steatosis, hemosiderosis, body mass index or alcohol intake, was observed. The frequency of diabetes mellitus increased along with pathological staging (3, 15 and 30% in stages I, II and III, respectively, p <0,05).
This study confirms that severity of chronic hepatitis C is associated with age and the presence of diabetes mellitus.</abstract><cop>Chile</cop><pmid>16446854</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-9887 |
| ispartof | Revista medíca de Chile, 2005-11, Vol.133 (11), p.1311-1316 |
| issn | 0034-9887 |
| language | spa |
| recordid | cdi_proquest_miscellaneous_69093719 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Alcohol Drinking - adverse effects Biopsy Body Mass Index Diabetes Complications Fatty Liver - pathology Female Hemosiderosis - etiology Hemosiderosis - pathology Hepatitis C virus Hepatitis C, Chronic - classification Hepatitis C, Chronic - pathology Humans Liver Cirrhosis - pathology Male Middle Aged Overweight Retrospective Studies Severity of Illness Index |
| title | Factors associated with the severity of liver damage in chronic hepatitis C |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T01%3A50%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Factors%20associated%20with%20the%20severity%20of%20liver%20damage%20in%20chronic%20hepatitis%20C&rft.jtitle=Revista%20med%C3%ADca%20de%20Chile&rft.au=Orellana%20N,%20Ivonne&rft.date=2005-11&rft.volume=133&rft.issue=11&rft.spage=1311&rft.epage=1316&rft.pages=1311-1316&rft.issn=0034-9887&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E17199714%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17199714&rft_id=info:pmid/16446854&rfr_iscdi=true |