The soluble pool of HLA-G produced by human trophoblasts does not include detectable levels of the intron 4-containing HLA-G5 and HLA-G6 isoforms

In the context of implantation and pregnancy, several immunomodulating functions have been attributed to the different HLA-G isoforms. Increasing attention is now being addressed to the actively secreted soluble forms, because they might have a systemic function or could be useful as diagnostic tool...

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Veröffentlicht in:	Molecular human reproduction 2005-10, Vol.11 (10), p.699-710
Hauptverfasser:	Blaschitz, A., Juch, H., Volz, A., Hutter, H., Daxboeck, C., Desoye, G., Dohr, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal Biological and medical sciences Biomarkers Birth control Cell Line Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gynecology. Andrology. Obstetrics Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism HLA Antigens - genetics HLA Antigens - immunology HLA Antigens - metabolism HLA-G HLA-G Antigens human placenta Humans Immunobiology Labor, Obstetric Lymphokines, interleukins ( function, expression) Medical sciences MHC class I Placenta - metabolism Pregnancy Pregnancy Trimester, First Protein Isoforms - genetics Protein Isoforms - immunology Protein Isoforms - metabolism Protein Processing, Post-Translational Regulatory factors and their cellular receptors reproductive immunology Sterility. Assisted procreation trophoblast Trophoblasts - metabolism
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