Branched synthetic peptide constructs mimic cellular binding and efflux of apolipoprotein AI in reconstituted high density lipoproteins

This study investigates the suitability of the trimeric apolipoprotein (apo) AI(145–183) peptide that we recently described, to serve as a model to probe the relationship between apo AI structure and function. Three copies of the apoAI(145–183) unit, composed each of two amphipatic α-helical segment...

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Veröffentlicht in:	Atherosclerosis 1998-12, Vol.141 (2), p.227-235
Hauptverfasser:	Nion, Stéphane, Demoor, Ludovic, Boutillon, Christophe, Luchoomun, Jayraz, Vanloo, Berlinda, Fievet, Catherine, Castro, Graciela, Rosseneu, Maryvonne, Fruchart, Jean-Charles, Tartar, André, Clavey, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein A-I - chemistry Apolipoprotein A-I - metabolism Apolipoprotein AI Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Branched peptide Cardiology. Vascular system Cell binding Cholesterol - metabolism Cholesterol efflux HeLa Cells Humans LCAT Lipoproteins, HDL - metabolism Liver Neoplasms, Experimental Medical sciences Peptides - chemical synthesis Phosphatidylcholine-Sterol O-Acyltransferase - physiology Protein Conformation Rats Reconstituted high density lipoprotein Tumor Cells, Cultured
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