T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY

Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proli...

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Veröffentlicht in:	The Journal of parasitology 2007-10, Vol.93 (5), p.1036-1045
Hauptverfasser:	Shin, Eun-Hee, Lee, Sang-Hyup, Kim, Jae-Lip, Park, Yun-Kyu, Chai, Jong-Yil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics Antigens Biological and medical sciences CD4 antigen CD8 antigen Cytokines Expulsion Fatalities Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Hyperplasia Immune response (cell-mediated) Immunoglobulin A Immunoglobulin G Immunoglobulin M IMMUNOLOGY Infections Interferon Interferon-gamma - biosynthesis Interleukin 4 Interleukin-4 - biosynthesis Intestinal Diseases, Parasitic - immunology Intestinal Diseases, Parasitic - mortality Intestinal Diseases, Parasitic - parasitology Intestinal Mucosa - immunology Intestine Intestine, Small - immunology Intestine, Small - parasitology Invertebrates Life sciences Lymph nodes Lymphocyte Activation Lymphocytes Lymphocytes T Macrophages Macrophages, Peritoneal - immunology Macrophages, Peritoneal - parasitology Male Memory interference Mice Mice, Inbred BALB C Microscopy, Electron, Scanning mRNA Neodiplostomum Parasite hosts Parasites Parasitology Rats Rats, Sprague-Dawley Small intestine Specific Pathogen-Free Organisms Spleen Spleen - cytology Spleen - immunology T lymphocytes Th1 Cells - immunology Th2 Cells - immunology Trematoda Trematoda - immunology Trematoda - isolation & purification Trematoda - pathogenicity Trematode Infections - immunology Trematode Infections - mortality Trematode Infections - parasitology Worms γ-Interferon
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