T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY
Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proli...
Gespeichert in:
| Veröffentlicht in: | The Journal of parasitology 2007-10, Vol.93 (5), p.1036-1045 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1045 |
|---|---|
| container_issue | 5 |
| container_start_page | 1036 |
| container_title | The Journal of parasitology |
| container_volume | 93 |
| creator | Shin, Eun-Hee Lee, Sang-Hyup Kim, Jae-Lip Park, Yun-Kyu Chai, Jong-Yil |
| description | Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proliferated in response to parasite antigens; CD4+ T cells proliferated more than CD8+ T cells. Antigen-induced interferon (IFN)-γ (a Th1 cytokine) secretion began to increase at day 7 postinfection (PI) in spleen and MLN cells, and this was maintained at day 28 PI, whereas interleukin (IL)-4 (a Th2 cytokine) secretion was somewhat lower. Similar results were observed for mRNA signals of IFN-γ and IL-4. Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. Interestingly, the numbers of macrophages (Th1- or Th2-induced), which were found to kill N. seoulense worms in vitro, increased remarkably during days 14–28 PI in spleens and small intestines of infected mice. This study shows that mixed Th1 and Th2 responses occur during the course of N. seoulense infection in BALB/c mice. Heavy infiltrations of macrophages in the small intestine may participate in host damage and worm expulsion. |
| doi_str_mv | 10.1645/GE-1203R.1 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_69090676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40058823</jstor_id><sourcerecordid>40058823</sourcerecordid><originalsourceid>FETCH-LOGICAL-b429t-e1106a70df8016290bd2cb4aa6130dc7744e32bbcea968a9c8a1a1533dfa04dd3</originalsourceid><addsrcrecordid>eNqFkkuP0zAUhS0EYjqFDXuQJQRCSBn8ipOwy7Rua-EkVeJoYBU5j0qt2maI2wX_iJ-JO61mJBawsK58z-eje3UMwBuMbjBn_pe58DBBNL_Bz8AIRzTwCGX-czBCiBCP0si_AtfWbhBCvjsvwRUOMaeUBiPwW3sLoZYi9zCM0yl8vBIok6RMBcxFsczSQhRQpjCRE-HqTEy0mMI7qRdQL04dLQot01jBmSq_CZiKbCqXKit0lpQJLERWKuFMvp5wmcNlVhTyVjn3TJ2d77I8geL7slSFzNKHWRbuOZzFOlZS_3gFXqzM1navL3UMypnQk4WnsrmcxMqrGYkOXocx4iZA7SpEmJMI1S1pamYMxxS1TRAw1lFS101nIh6aqAkNNtintF0ZxNqWjsHHs-_90P88dvZQ7da26bZbs-_6o614hCLEA_5f0AXBEPaJA9__BW7647B3S1SE-z4iDPnMUZ_PVDP01g7dqrof1jsz_Kowqk4xV3NRPcRcYQe_u1ge613XPqGXXB3w4QIY25jtajD7Zm2fuCgM-Ykcg7dnbmMP_fCoM_dTwpCc9E9nvV73_b7710x_ALBCtv0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2655024054</pqid></control><display><type>article</type><title>T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY</title><source>JSTOR Archive Collection A-Z Listing</source><source>MEDLINE</source><source>BioOne Complete</source><creator>Shin, Eun-Hee ; Lee, Sang-Hyup ; Kim, Jae-Lip ; Park, Yun-Kyu ; Chai, Jong-Yil</creator><creatorcontrib>Shin, Eun-Hee ; Lee, Sang-Hyup ; Kim, Jae-Lip ; Park, Yun-Kyu ; Chai, Jong-Yil</creatorcontrib><description>Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proliferated in response to parasite antigens; CD4+ T cells proliferated more than CD8+ T cells. Antigen-induced interferon (IFN)-γ (a Th1 cytokine) secretion began to increase at day 7 postinfection (PI) in spleen and MLN cells, and this was maintained at day 28 PI, whereas interleukin (IL)-4 (a Th2 cytokine) secretion was somewhat lower. Similar results were observed for mRNA signals of IFN-γ and IL-4. Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. Interestingly, the numbers of macrophages (Th1- or Th2-induced), which were found to kill N. seoulense worms in vitro, increased remarkably during days 14–28 PI in spleens and small intestines of infected mice. This study shows that mixed Th1 and Th2 responses occur during the course of N. seoulense infection in BALB/c mice. Heavy infiltrations of macrophages in the small intestine may participate in host damage and worm expulsion.</description><identifier>ISSN: 0022-3395</identifier><identifier>EISSN: 1937-2345</identifier><identifier>DOI: 10.1645/GE-1203R.1</identifier><identifier>PMID: 18163337</identifier><identifier>CODEN: JOPAA2</identifier><language>eng</language><publisher>Lawrence, KS: American Society of Parasitologists</publisher><subject>Animals ; Antibiotics ; Antigens ; Biological and medical sciences ; CD4 antigen ; CD8 antigen ; Cytokines ; Expulsion ; Fatalities ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Hyperplasia ; Immune response (cell-mediated) ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; IMMUNOLOGY ; Infections ; Interferon ; Interferon-gamma - biosynthesis ; Interleukin 4 ; Interleukin-4 - biosynthesis ; Intestinal Diseases, Parasitic - immunology ; Intestinal Diseases, Parasitic - mortality ; Intestinal Diseases, Parasitic - parasitology ; Intestinal Mucosa - immunology ; Intestine ; Intestine, Small - immunology ; Intestine, Small - parasitology ; Invertebrates ; Life sciences ; Lymph nodes ; Lymphocyte Activation ; Lymphocytes ; Lymphocytes T ; Macrophages ; Macrophages, Peritoneal - immunology ; Macrophages, Peritoneal - parasitology ; Male ; Memory interference ; Mice ; Mice, Inbred BALB C ; Microscopy, Electron, Scanning ; mRNA ; Neodiplostomum ; Parasite hosts ; Parasites ; Parasitology ; Rats ; Rats, Sprague-Dawley ; Small intestine ; Specific Pathogen-Free Organisms ; Spleen ; Spleen - cytology ; Spleen - immunology ; T lymphocytes ; Th1 Cells - immunology ; Th2 Cells - immunology ; Trematoda ; Trematoda - immunology ; Trematoda - isolation & purification ; Trematoda - pathogenicity ; Trematode Infections - immunology ; Trematode Infections - mortality ; Trematode Infections - parasitology ; Worms ; γ-Interferon</subject><ispartof>The Journal of parasitology, 2007-10, Vol.93 (5), p.1036-1045</ispartof><rights>American Society of Parasitologists</rights><rights>Copyright 2007 American Society of Parasitologists</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Allen Press Inc. Oct 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b429t-e1106a70df8016290bd2cb4aa6130dc7744e32bbcea968a9c8a1a1533dfa04dd3</citedby><cites>FETCH-LOGICAL-b429t-e1106a70df8016290bd2cb4aa6130dc7744e32bbcea968a9c8a1a1533dfa04dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1645/GE-1203R.1$$EPDF$$P50$$Gbioone$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40058823$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,26955,27901,27902,52338,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19886633$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18163337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Eun-Hee</creatorcontrib><creatorcontrib>Lee, Sang-Hyup</creatorcontrib><creatorcontrib>Kim, Jae-Lip</creatorcontrib><creatorcontrib>Park, Yun-Kyu</creatorcontrib><creatorcontrib>Chai, Jong-Yil</creatorcontrib><title>T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY</title><title>The Journal of parasitology</title><addtitle>J Parasitol</addtitle><description>Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proliferated in response to parasite antigens; CD4+ T cells proliferated more than CD8+ T cells. Antigen-induced interferon (IFN)-γ (a Th1 cytokine) secretion began to increase at day 7 postinfection (PI) in spleen and MLN cells, and this was maintained at day 28 PI, whereas interleukin (IL)-4 (a Th2 cytokine) secretion was somewhat lower. Similar results were observed for mRNA signals of IFN-γ and IL-4. Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. Interestingly, the numbers of macrophages (Th1- or Th2-induced), which were found to kill N. seoulense worms in vitro, increased remarkably during days 14–28 PI in spleens and small intestines of infected mice. This study shows that mixed Th1 and Th2 responses occur during the course of N. seoulense infection in BALB/c mice. Heavy infiltrations of macrophages in the small intestine may participate in host damage and worm expulsion.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cytokines</subject><subject>Expulsion</subject><subject>Fatalities</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Hyperplasia</subject><subject>Immune response (cell-mediated)</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>IMMUNOLOGY</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin 4</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Intestinal Diseases, Parasitic - immunology</subject><subject>Intestinal Diseases, Parasitic - mortality</subject><subject>Intestinal Diseases, Parasitic - parasitology</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestine</subject><subject>Intestine, Small - immunology</subject><subject>Intestine, Small - parasitology</subject><subject>Invertebrates</subject><subject>Life sciences</subject><subject>Lymph nodes</subject><subject>Lymphocyte Activation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - parasitology</subject><subject>Male</subject><subject>Memory interference</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microscopy, Electron, Scanning</subject><subject>mRNA</subject><subject>Neodiplostomum</subject><subject>Parasite hosts</subject><subject>Parasites</subject><subject>Parasitology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Small intestine</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>T lymphocytes</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Trematoda</subject><subject>Trematoda - immunology</subject><subject>Trematoda - isolation & purification</subject><subject>Trematoda - pathogenicity</subject><subject>Trematode Infections - immunology</subject><subject>Trematode Infections - mortality</subject><subject>Trematode Infections - parasitology</subject><subject>Worms</subject><subject>γ-Interferon</subject><issn>0022-3395</issn><issn>1937-2345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkkuP0zAUhS0EYjqFDXuQJQRCSBn8ipOwy7Rua-EkVeJoYBU5j0qt2maI2wX_iJ-JO61mJBawsK58z-eje3UMwBuMbjBn_pe58DBBNL_Bz8AIRzTwCGX-czBCiBCP0si_AtfWbhBCvjsvwRUOMaeUBiPwW3sLoZYi9zCM0yl8vBIok6RMBcxFsczSQhRQpjCRE-HqTEy0mMI7qRdQL04dLQot01jBmSq_CZiKbCqXKit0lpQJLERWKuFMvp5wmcNlVhTyVjn3TJ2d77I8geL7slSFzNKHWRbuOZzFOlZS_3gFXqzM1navL3UMypnQk4WnsrmcxMqrGYkOXocx4iZA7SpEmJMI1S1pamYMxxS1TRAw1lFS101nIh6aqAkNNtintF0ZxNqWjsHHs-_90P88dvZQ7da26bZbs-_6o614hCLEA_5f0AXBEPaJA9__BW7647B3S1SE-z4iDPnMUZ_PVDP01g7dqrof1jsz_Kowqk4xV3NRPcRcYQe_u1ge613XPqGXXB3w4QIY25jtajD7Zm2fuCgM-Ykcg7dnbmMP_fCoM_dTwpCc9E9nvV73_b7710x_ALBCtv0</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Shin, Eun-Hee</creator><creator>Lee, Sang-Hyup</creator><creator>Kim, Jae-Lip</creator><creator>Park, Yun-Kyu</creator><creator>Chai, Jong-Yil</creator><general>American Society of Parasitologists</general><general>Allen Press Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7SN</scope><scope>7SS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY</title><author>Shin, Eun-Hee ; Lee, Sang-Hyup ; Kim, Jae-Lip ; Park, Yun-Kyu ; Chai, Jong-Yil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b429t-e1106a70df8016290bd2cb4aa6130dc7744e32bbcea968a9c8a1a1533dfa04dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>Cytokines</topic><topic>Expulsion</topic><topic>Fatalities</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Hyperplasia</topic><topic>Immune response (cell-mediated)</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>IMMUNOLOGY</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin 4</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Intestinal Diseases, Parasitic - immunology</topic><topic>Intestinal Diseases, Parasitic - mortality</topic><topic>Intestinal Diseases, Parasitic - parasitology</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestine</topic><topic>Intestine, Small - immunology</topic><topic>Intestine, Small - parasitology</topic><topic>Invertebrates</topic><topic>Life sciences</topic><topic>Lymph nodes</topic><topic>Lymphocyte Activation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - parasitology</topic><topic>Male</topic><topic>Memory interference</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microscopy, Electron, Scanning</topic><topic>mRNA</topic><topic>Neodiplostomum</topic><topic>Parasite hosts</topic><topic>Parasites</topic><topic>Parasitology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Small intestine</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>T lymphocytes</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - immunology</topic><topic>Trematoda</topic><topic>Trematoda - immunology</topic><topic>Trematoda - isolation & purification</topic><topic>Trematoda - pathogenicity</topic><topic>Trematode Infections - immunology</topic><topic>Trematode Infections - mortality</topic><topic>Trematode Infections - parasitology</topic><topic>Worms</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Eun-Hee</creatorcontrib><creatorcontrib>Lee, Sang-Hyup</creatorcontrib><creatorcontrib>Kim, Jae-Lip</creatorcontrib><creatorcontrib>Park, Yun-Kyu</creatorcontrib><creatorcontrib>Chai, Jong-Yil</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Eun-Hee</au><au>Lee, Sang-Hyup</au><au>Kim, Jae-Lip</au><au>Park, Yun-Kyu</au><au>Chai, Jong-Yil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY</atitle><jtitle>The Journal of parasitology</jtitle><addtitle>J Parasitol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>93</volume><issue>5</issue><spage>1036</spage><epage>1045</epage><pages>1036-1045</pages><issn>0022-3395</issn><eissn>1937-2345</eissn><coden>JOPAA2</coden><abstract>Neodiplostomum seoulense is highly pathogenic and lethal to experimental mice; most worms are expelled within 2 mo of acquisition. In this study, T-helper (Th) cell immune responses were studied in N. seoulense-infected BALB/c mice. Spleen and mesenteric lymph node (MLN) cells of infected mice proliferated in response to parasite antigens; CD4+ T cells proliferated more than CD8+ T cells. Antigen-induced interferon (IFN)-γ (a Th1 cytokine) secretion began to increase at day 7 postinfection (PI) in spleen and MLN cells, and this was maintained at day 28 PI, whereas interleukin (IL)-4 (a Th2 cytokine) secretion was somewhat lower. Similar results were observed for mRNA signals of IFN-γ and IL-4. Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. Interestingly, the numbers of macrophages (Th1- or Th2-induced), which were found to kill N. seoulense worms in vitro, increased remarkably during days 14–28 PI in spleens and small intestines of infected mice. This study shows that mixed Th1 and Th2 responses occur during the course of N. seoulense infection in BALB/c mice. Heavy infiltrations of macrophages in the small intestine may participate in host damage and worm expulsion.</abstract><cop>Lawrence, KS</cop><pub>American Society of Parasitologists</pub><pmid>18163337</pmid><doi>10.1645/GE-1203R.1</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3395 |
| ispartof | The Journal of parasitology, 2007-10, Vol.93 (5), p.1036-1045 |
| issn | 0022-3395 1937-2345 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69090676 |
| source | JSTOR Archive Collection A-Z Listing; MEDLINE; BioOne Complete |
| subjects | Animals Antibiotics Antigens Biological and medical sciences CD4 antigen CD8 antigen Cytokines Expulsion Fatalities Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Hyperplasia Immune response (cell-mediated) Immunoglobulin A Immunoglobulin G Immunoglobulin M IMMUNOLOGY Infections Interferon Interferon-gamma - biosynthesis Interleukin 4 Interleukin-4 - biosynthesis Intestinal Diseases, Parasitic - immunology Intestinal Diseases, Parasitic - mortality Intestinal Diseases, Parasitic - parasitology Intestinal Mucosa - immunology Intestine Intestine, Small - immunology Intestine, Small - parasitology Invertebrates Life sciences Lymph nodes Lymphocyte Activation Lymphocytes Lymphocytes T Macrophages Macrophages, Peritoneal - immunology Macrophages, Peritoneal - parasitology Male Memory interference Mice Mice, Inbred BALB C Microscopy, Electron, Scanning mRNA Neodiplostomum Parasite hosts Parasites Parasitology Rats Rats, Sprague-Dawley Small intestine Specific Pathogen-Free Organisms Spleen Spleen - cytology Spleen - immunology T lymphocytes Th1 Cells - immunology Th2 Cells - immunology Trematoda Trematoda - immunology Trematoda - isolation & purification Trematoda - pathogenicity Trematode Infections - immunology Trematode Infections - mortality Trematode Infections - parasitology Worms γ-Interferon |
| title | T-HELPER-1 AND T-HELPER-2 IMMUNE RESPONSES IN MICE INFECTED WITH THE INTESTINAL FLUKE NEODIPLOSTOMUM SEOULENSE: THEIR POSSIBLE ROLES IN WORM EXPULSION AND HOST FATALITY |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T04%3A28%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=T-HELPER-1%20AND%20T-HELPER-2%20IMMUNE%20RESPONSES%20IN%20MICE%20INFECTED%20WITH%20THE%20INTESTINAL%20FLUKE%20NEODIPLOSTOMUM%20SEOULENSE:%20THEIR%20POSSIBLE%20ROLES%20IN%20WORM%20EXPULSION%20AND%20HOST%20FATALITY&rft.jtitle=The%20Journal%20of%20parasitology&rft.au=Shin,%20Eun-Hee&rft.date=2007-10-01&rft.volume=93&rft.issue=5&rft.spage=1036&rft.epage=1045&rft.pages=1036-1045&rft.issn=0022-3395&rft.eissn=1937-2345&rft.coden=JOPAA2&rft_id=info:doi/10.1645/GE-1203R.1&rft_dat=%3Cjstor_proqu%3E40058823%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2655024054&rft_id=info:pmid/18163337&rft_jstor_id=40058823&rfr_iscdi=true |