Increased responsiveness to 5-hydroxytryptamine after antigenic challenge is inhibited by nifedipine and niflumic acid in rat trachea in vitro

Summary 1. Antigenic challenge often induces hyperreactivity in asthmatic airway, although the precise mechanism(s) underlying this increased responsiveness is not entirely known. 2. Tracheae obtained from ovalbumin (OVA)‐sensitized saline‐ or OVA‐challenged rats were placed in 10 mL bath chambers f...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2005-12, Vol.32 (12), p.1119-1123
Hauptverfasser:	Moura, Carlos Tiago Martins, Bezerra, Fernanda Carvalho, De Moraes, Isabelle Maciel, Magalhães, Pedro Jorge Caldas, Capaz, Francisco Ruy
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptamine Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antigens - pharmacology asthma Calcium - physiology Calcium Channel Blockers - pharmacology Dose-Response Relationship, Drug hyperresponsiveness In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Nifedipine - pharmacology Niflumic Acid - pharmacology rat airway Rats Rats, Wistar serotonin Serotonin - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Trachea - drug effects Trachea - immunology Trachea - metabolism voltage-operated channel
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