Exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/prodrug therapy

Bifidobacteria are nonpathogenic, anaerobic domestic bacteria with health-promoting properties for the host. In our previous study, Bifidobacterium longum (B. longum) were found to be localized selectively and to proliferate within solid tumors after systemic application. Additionally, B. longum tra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-12, Vol.71 (12), p.2921-2926
Hauptverfasser:	Hidaka, Ayumi, Hamaji, Yoshinori, Sasaki, Takayuki, Taniguchi, Shun'ichiro, Fujimori, Minoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Bifidobacterium - genetics Bifidobacterium - metabolism Cell Line, Tumor Cytosine Deaminase - genetics Cytosine Deaminase - metabolism Drug Delivery Systems Flucytosine - metabolism Flucytosine - therapeutic use Fluorouracil - metabolism Humans Lung Neoplasms - drug therapy Lung Neoplasms - microbiology Male Mice Mice, Inbred C57BL Neoplasm Transplantation Plasmids Prodrugs - metabolism Prodrugs - therapeutic use Transplantation, Heterologous
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!