(99m)Tc-EDDA/HYNIC-octreotate - a new radiotracer for detection and staging of NET: a case of metastatic duodenal carcinoid
Somatostatin receptor scintigraphy (SRS) has become a routine imaging method for the diagnostics of neuroendocrine tumours (NET). (99m)Tc-EDDA/HYNIC-octreotate (Polatom, Poland) is a new radiotracer with high affinity for SSTR2 and similar physiological biodistribution to (111)In-Octreoscan. We pres...
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| Veröffentlicht in: | Nuclear medicine review. Central & Eastern Europe 2005, Vol.8 (2), p.155-156 |
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| creator | Hubalewska-Dydejczyk, Alicja Szybiński, Piotr Fröss-Baron, Katarzyna Mikolajczak, Renata Huszno, Bohdan Sowa-Staszczak, Anna |
| description | Somatostatin receptor scintigraphy (SRS) has become a routine imaging method for the diagnostics of neuroendocrine tumours (NET). (99m)Tc-EDDA/HYNIC-octreotate (Polatom, Poland) is a new radiotracer with high affinity for SSTR2 and similar physiological biodistribution to (111)In-Octreoscan. We present a case of a 47-year-old man with disseminated duodenal carcinoid. The patient had been operated due to the tumour mass detected in pancreatic head area. Histopathology revealed carcinoid of the duodenal wall with local lymph node and liver metastases. The patient was qualified for chemotherapy stopped due to severe leucopenia. (99m)Tc EDDA/HYNIC-octreotate scintigraphy was performed for staging and to determine SSTR status of the tumour before planned 90Y-DOTATATE therapy. The multiple metastatic lesions were detected all over the body. The high quality images with high target/non target ratio were obtained. (99m)Tc-MDP scintigraphy confirmed multiple bone metastases. On the basis of SRS result the patient was qualified for 90Y-DOTA-TATE therapy. In conclusion, (99m)Tc EDDA/HYNIC-octreotate can be regarded as a promising tracer for staging and to determine SSTR status of NET. |
| format | Article |
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(99m)Tc-EDDA/HYNIC-octreotate (Polatom, Poland) is a new radiotracer with high affinity for SSTR2 and similar physiological biodistribution to (111)In-Octreoscan. We present a case of a 47-year-old man with disseminated duodenal carcinoid. The patient had been operated due to the tumour mass detected in pancreatic head area. Histopathology revealed carcinoid of the duodenal wall with local lymph node and liver metastases. The patient was qualified for chemotherapy stopped due to severe leucopenia. (99m)Tc EDDA/HYNIC-octreotate scintigraphy was performed for staging and to determine SSTR status of the tumour before planned 90Y-DOTATATE therapy. The multiple metastatic lesions were detected all over the body. The high quality images with high target/non target ratio were obtained. (99m)Tc-MDP scintigraphy confirmed multiple bone metastases. On the basis of SRS result the patient was qualified for 90Y-DOTA-TATE therapy. In conclusion, (99m)Tc EDDA/HYNIC-octreotate can be regarded as a promising tracer for staging and to determine SSTR status of NET.</description><identifier>ISSN: 1506-9680</identifier><identifier>PMID: 16437406</identifier><language>eng</language><publisher>Poland</publisher><subject>Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Duodenal Neoplasms - diagnostic imaging ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Neuroendocrine Tumors - diagnostic imaging ; Neuroendocrine Tumors - secondary ; Organotechnetium Compounds ; Radionuclide Imaging ; Radiopharmaceuticals ; Whole Body Imaging</subject><ispartof>Nuclear medicine review. 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Central & Eastern Europe</title><addtitle>Nucl Med Rev Cent East Eur</addtitle><description>Somatostatin receptor scintigraphy (SRS) has become a routine imaging method for the diagnostics of neuroendocrine tumours (NET). (99m)Tc-EDDA/HYNIC-octreotate (Polatom, Poland) is a new radiotracer with high affinity for SSTR2 and similar physiological biodistribution to (111)In-Octreoscan. We present a case of a 47-year-old man with disseminated duodenal carcinoid. The patient had been operated due to the tumour mass detected in pancreatic head area. Histopathology revealed carcinoid of the duodenal wall with local lymph node and liver metastases. The patient was qualified for chemotherapy stopped due to severe leucopenia. (99m)Tc EDDA/HYNIC-octreotate scintigraphy was performed for staging and to determine SSTR status of the tumour before planned 90Y-DOTATATE therapy. The multiple metastatic lesions were detected all over the body. The high quality images with high target/non target ratio were obtained. (99m)Tc-MDP scintigraphy confirmed multiple bone metastases. On the basis of SRS result the patient was qualified for 90Y-DOTA-TATE therapy. In conclusion, (99m)Tc EDDA/HYNIC-octreotate can be regarded as a promising tracer for staging and to determine SSTR status of NET.</description><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Duodenal Neoplasms - diagnostic imaging</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neuroendocrine Tumors - diagnostic imaging</subject><subject>Neuroendocrine Tumors - secondary</subject><subject>Organotechnetium Compounds</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Whole Body Imaging</subject><issn>1506-9680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDFPwzAUhD2AaCn8BeQJwRDhOIkTs1VtgUpVWbIwRS_Oc2WU2MV2hBB_niDKdDrddzfcGZmnBROJFBWbkcsQ3hkrcs7TCzJLRZ6VORNz8n0n5XBfq2SzXi8fXt7221XiVPToIkSkCQVq8ZN66IyLHhR6qp2nHUZU0ThLwXY0RDgYe6BO0_2mfpw6CgL-2gEjTGk0inaj69BCP2VeGetMd0XONfQBr0-6IPXTpl69JLvX5-1quUuOKc9jwmXLhCqhlTqXUCiVtxqU1BVvATLUoqyEwkprxkTGJSsUB8HSokxbwco0W5Dbv9mjdx8jhtgMJijse7DoxtAIySrBimwCb07g2A7YNUdvBvBfzf9b2Q8An2RV</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Hubalewska-Dydejczyk, Alicja</creator><creator>Szybiński, Piotr</creator><creator>Fröss-Baron, Katarzyna</creator><creator>Mikolajczak, Renata</creator><creator>Huszno, Bohdan</creator><creator>Sowa-Staszczak, Anna</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>(99m)Tc-EDDA/HYNIC-octreotate - a new radiotracer for detection and staging of NET: a case of metastatic duodenal carcinoid</title><author>Hubalewska-Dydejczyk, Alicja ; Szybiński, Piotr ; Fröss-Baron, Katarzyna ; Mikolajczak, Renata ; Huszno, Bohdan ; Sowa-Staszczak, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-29b06c7ab9f49a5cc4bfac9f82baa3ef6786ce8ff00632905c2a601571b60713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Duodenal Neoplasms - diagnostic imaging</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neuroendocrine Tumors - diagnostic imaging</topic><topic>Neuroendocrine Tumors - secondary</topic><topic>Organotechnetium Compounds</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>Whole Body Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hubalewska-Dydejczyk, Alicja</creatorcontrib><creatorcontrib>Szybiński, Piotr</creatorcontrib><creatorcontrib>Fröss-Baron, Katarzyna</creatorcontrib><creatorcontrib>Mikolajczak, Renata</creatorcontrib><creatorcontrib>Huszno, Bohdan</creatorcontrib><creatorcontrib>Sowa-Staszczak, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine review. Central & Eastern Europe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hubalewska-Dydejczyk, Alicja</au><au>Szybiński, Piotr</au><au>Fröss-Baron, Katarzyna</au><au>Mikolajczak, Renata</au><au>Huszno, Bohdan</au><au>Sowa-Staszczak, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(99m)Tc-EDDA/HYNIC-octreotate - a new radiotracer for detection and staging of NET: a case of metastatic duodenal carcinoid</atitle><jtitle>Nuclear medicine review. Central & Eastern Europe</jtitle><addtitle>Nucl Med Rev Cent East Eur</addtitle><date>2005</date><risdate>2005</risdate><volume>8</volume><issue>2</issue><spage>155</spage><epage>156</epage><pages>155-156</pages><issn>1506-9680</issn><abstract>Somatostatin receptor scintigraphy (SRS) has become a routine imaging method for the diagnostics of neuroendocrine tumours (NET). (99m)Tc-EDDA/HYNIC-octreotate (Polatom, Poland) is a new radiotracer with high affinity for SSTR2 and similar physiological biodistribution to (111)In-Octreoscan. We present a case of a 47-year-old man with disseminated duodenal carcinoid. The patient had been operated due to the tumour mass detected in pancreatic head area. Histopathology revealed carcinoid of the duodenal wall with local lymph node and liver metastases. The patient was qualified for chemotherapy stopped due to severe leucopenia. (99m)Tc EDDA/HYNIC-octreotate scintigraphy was performed for staging and to determine SSTR status of the tumour before planned 90Y-DOTATATE therapy. The multiple metastatic lesions were detected all over the body. The high quality images with high target/non target ratio were obtained. (99m)Tc-MDP scintigraphy confirmed multiple bone metastases. On the basis of SRS result the patient was qualified for 90Y-DOTA-TATE therapy. In conclusion, (99m)Tc EDDA/HYNIC-octreotate can be regarded as a promising tracer for staging and to determine SSTR status of NET.</abstract><cop>Poland</cop><pmid>16437406</pmid><tpages>2</tpages></addata></record> |
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| subjects | Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Duodenal Neoplasms - diagnostic imaging Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary Lymphatic Metastasis Male Middle Aged Neoplasm Staging Neuroendocrine Tumors - diagnostic imaging Neuroendocrine Tumors - secondary Organotechnetium Compounds Radionuclide Imaging Radiopharmaceuticals Whole Body Imaging |
| title | (99m)Tc-EDDA/HYNIC-octreotate - a new radiotracer for detection and staging of NET: a case of metastatic duodenal carcinoid |
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