Different Frequency of Gene Targeting Events by the RNA-DNA Oligonucleotide Among Epithelial Cells

A unique hybrid oligonucleotide composed of both RNA and DNA has been shown to correct a point mutation in a site-specific and inheritable manner in extrachromosomal and chromosomal targets. In order to develop new gene therapeutics for skin, we tested two oligonucleotides that were shown to create...

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Veröffentlicht in:	Journal of investigative dermatology 1998-12, Vol.111 (6), p.1172-1177
Hauptverfasser:	Santana, Evelyn, Peritz, Adam E., Iyer, Subramanian, Uitto, Jouni, Yoon, Kyonggeun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Biological and medical sciences Biotechnology Cell Adhesion Molecules, Neuronal - pharmacology Cell Line Contactin 2 DNA - genetics DNA-Binding Proteins - pharmacology Epithelial Cells - metabolism Fundamental and applied biological sciences. Psychology Gene Targeting Gene therapy Globins - genetics HaCaT Health. Pharmaceutical industry HeLa HeLa Cells - chemistry Humans Industrial applications and implications. Economical aspects Infant, Newborn keratinocytes Keratinocytes - cytology Male Microscopy, Fluorescence nucleotide uptake Oligonucleotides - genetics Phosphorus Radioisotopes Point Mutation RNA - genetics site-specific mutagenesis Transcription Factor AP-2 Transcription Factors - pharmacology
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